The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Informacje na temat projektu

EU-TRAIN

Identyfikator umowy o grant: 754995

DOI

10.3030/754995

Projekt został zamknięty

Data podpisania przez KE 27 Listopada 2017

Data rozpoczęcia 1 Stycznia 2018

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 641 546,00

Wkład UE

€ 6 641 546,00

Koordynowany przez

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (2)

EUTRAIN-ESOT statistics course on risk stratification
EU-TRAIN session in ESOT events

EU-TRAIN session in ESOT events (M28 and M54)

Websites, patent fillings, videos etc. (1)

Communication and Dissemination tools

Publikacje

Peer reviewed articles (30)

Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization

Autorzy: Júlia Nakanishi Usuda, Desirée Rodrigues Plaça, Dennyson Leandro M. Fonseca, Alexandre H. C. Marques, Igor Salerno Filgueiras, Victor Gabriel Bastos Chaves, Anny Silva Adri, Amanda Torrentes-Carvalho, Mario Hiroyuki Hirata, Paula Paccielli Freire, Rusan Catar, Gustavo Cabral-Miranda, Lena F. Schimke, Guido Moll, Otavio Cabral-Marques
Opublikowane w: Frontiers in Immunology, Numer 14, 2023, ISSN 1664-3224
Wydawca: Fron. Immunol.
DOI: 10.3389/fimmu.2023.1243516

Surfing the Big Data Wave: Omics Data Challenges in Transplantation

Autorzy: Ba, Rokhaya; Geffard, Estelle; Douillard, Venceslas; Simon, Françoise; Mesnard, Laurent; Vince, Nicolas ; Gourraud, Pierre-Antoine; Limou, Sophie
Opublikowane w: Transplantation, 2021, ISSN 0041-1337
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000003992

Multiple sclerosis clinical decision support system based on projection to reference datasets

Autorzy: Chadia Ed-driouch , Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David-Axel Laplaud, Franck Mars, Cedric Dumas, Gilles Edan & Pierre-Antoine Gourraud
Opublikowane w: Annals of Clinical and Translational Neurology, Numer Volume 9, Numer 12, 2022, Strona(/y) 1863-1873, ISSN 2328-9503
Wydawca: -
DOI: 10.1002/acn3.51649

Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression

Autorzy: Danger R, Le Berre L, Cadoux M, Kerleau C, Papuchon E, Mai HL, Nguyen TV, Guérif P, Morelon E, Thaunat O, Legendre C, Anglicheau D, Lefaucheur C, Couzi L, Del Bello A, Kamar N, Le Quintrec M, Goutaudier V, Renaudin K, Giral M, Brouard S; DIVAT Consortium
Opublikowane w: Kidney International, Numer 2023 Jun;103(6):1167-1179, 2023, ISSN 0085-2538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.03.019

CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy

Autorzy: Marta Jarque, Edoardo Melilli, Elena Crespo, Anna Manonelles, Nuria Montero, Joan Torras, Josep M. Cruzado, Sergi Luque, Salvador Gil-Vernet, Josep M. Grinyó, Oriol Bestard
Opublikowane w: Transplantation, Numer 102, 2023, Strona(/y) e472-e480, ISSN 0041-1337
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000002421

Addressing the Challenges and Barriers to the Integration of Machine Learning into Clinical Practice: An Innovative Method to Hybrid Human–Machine Intelligence

Autorzy: Chadia Ed-driouch, Franck Mars, Pierre-Antoine Gourraud, Cédric Dumas
Opublikowane w: Sensors, Numer Volume 22, Numer 21, 2022, Strona(/y) 8313, ISSN 1424-8220
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22218313

A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

Autorzy: Daniel Yoo, Gillian Divard, Marc Raynaud, Aaron Cohen, Tom D. Mone, John Thomas Rosenthal, Andrew J. Bentall, Mark D. Stegall, Maarten Naesens, Huanxi Zhang, Changxi Wang, Juliette Gueguen, Nassim Kamar, Antoine Bouquegneau, Ibrahim Batal, Shana M. Coley, John S. Gill, Federico Oppenheimer, Erika De Sousa-Amorim, Dirk R. J. Kuypers, Antoine Durrbach, Daniel Seron, Marion Rabant, Jean-Paul Duong Va
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-44595-z

Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)

Autorzy: François R Girardin, Anna Nicolet, Oriol Bestard, Carmen Lefaucheur, Klemens Budde, Fabian Halleck, Sophie Brouard, Magali Giral, Pierre-Antoine Gourraud, Béatrice Horcholle, Jean Villard, Joachim Marti, Alexandre Loupy
Opublikowane w: Frontiers in Pharmacology, Numer 2023 April 27, 2023, Strona(/y) 14:1040584, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1040584

High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients

Autorzy: Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, José Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta, Irina B. Torres, Joana Sellarés, Manel Perelló, Hannah Kaminski, Lionel Couzi, Alexandre Loupy, Gaetano La Manna, Francesc Moreso, Paolo Crave
Opublikowane w: Kidney International, 2024, ISSN 0085-2538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.03.027

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling

Autorzy: Guido Moll, Christian Luecht, Michael Adu Gyamfi, Dennyson L. M. da Fonseca, Pinchao Wang, Hongfan Zhao, Zexian Gong, Lei Chen, Muhamad Imtiaz Ashraf, Harald Heidecke, Alexander Maximilian Hackel, Duska Dragun, Klemens Budde, Olaf Penack, Gabriela Riemekasten, Otávio Cabral-Marques, Janusz Witowski, Rusan Catar
Opublikowane w: Frontiers in Immunology, Numer 14, 2023, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1289744

Distributing HLA database in histocompatibility: a shift in HLA data governance

Autorzy: Sirine Sayadi 1, 2 Venceslas Douillard 3, 4 Nicolas Vince 3, 4 Mario Südholt 1, 2 Pierre-Antoine Gourraud 4, 3 
Opublikowane w: Exploration of Immunology , 2022, ISSN 2768-6655
Wydawca: Exploration of Immunology 

Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study

Autorzy: Raynaud M, Al-Awadhi S, Juric I, Divard G, Lombardi Y, Basic-Jukic N, Aubert O, Dubourg L, Masson I, Mariat C, Prié D, Pernin V, Le Quintrec M, Larson TS, Stegall MD, Bikbov B, Ruggenenti P, Mesnard L, Ibrahim HN, Nielsen MB, Matas AJ, Nankivell BJ, Benjamens S, Pol RA, Bakker SJL, Jouven X, Legendre C, Kamar N, Smith BH, Wadei HM, Durrbach A, Vincenti F, Remuzzi G, Lefaucheur C, Bentall AJ, Loup
Opublikowane w: The BMJ, Numer 2023 May, 2023, Strona(/y) 381:e073654, ISSN 0959-8138
Wydawca: BMJ
DOI: 10.1136/bmj-2022-073654

An automated histological classification system for precision diagnostics of kidney allografts

Autorzy: Yoo D, Goutaudier V, Divard G, Gueguen J, Astor BC, Aubert O, Raynaud M, Demir Z, Hogan J, Weng P, Smith J, Garro R, Warady BA, Zahr RS, Sablik M, Twombley K, Couzi L, Berney T, Boyer O, Duong-Van-Huyen JP, Giral M, Alsadi A, Gourraud PA, Morelon E, Le Quintrec M, Brouard S, Legendre C, Anglicheau D, Villard J, Zhong W, Kamar N, Bestard O, Djamali A, Budde K, Haas M, Lefaucheur C, Rabant M, Loupy
Opublikowane w: Nature medicine, Numer 2023 May, 2023, Strona(/y) 29(5):1211-1220, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-023-02323-6

Comparison of artificial intelligence and human-based prediction and stratification of the risk of long-term kidney allograft failure.

Autorzy: Divard G, Raynaud M, Tatapudi VS, Abdalla B, Bailly E, Assayag M, Binois Y, Cohen R, Zhang H, Ulloa C, Linhares K, Tedesco HS, Legendre C, Jouven X, Montgomery RA, Lefaucheur C, Aubert O, Loupy A
Opublikowane w: Communications medicine, Numer 2022 Nov, 2022, Strona(/y) 2(1):150, ISSN 2730-664X
Wydawca: PubMed Central
DOI: 10.1038/s43856-022-00201-9

Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

Autorzy: Valentin Goutaudier, Richard Danger, Rusan Ali Catar, Maud Racapé, Aurélie Philippe, Michelle Elias, Marc Raynaud, Olivier Aubert, Didier Bouton, François Girardin, Éric Vicaut, Sarhan Yaiche, Jacques Demotes, Harald Heidecke, Jean-Luc Taupin, Christine Randoux-Lebrun, Mohamad Zaidan, Emmanuelle Papuchon, Hoa Le Mai, Thi-Van-Ha Nguyen, Francesc Moreso, Thierry Berney, Jean Villard, Christophe
Opublikowane w: Kidney International, 2024, ISSN 0085-2538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2024.07.027

Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients

Autorzy: Gillian Divard, Olivier Aubert, Charlotte Debiais-Deschamp, Marc Raynaud, Valentin Goutaudier, Marta Sablik, Caroline Sayeg, Christophe Legendre, Julie Obert, Dany Anglicheau, Carmen Lefaucheur, Alexandre Loupy
Opublikowane w: Clinical Journal of the American Society of Nephrology, 2024, ISSN 1555-9041
Wydawca: American Society of Nephrology
DOI: 10.2215/cjn.0000000000000411

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

Autorzy: Thayna Silva-Sousa, Júlia Nakanishi Usuda, Nada Al-Arawe, Francisca Frias, Irene Hinterseher, Rusan Catar, Christian Luecht, Katarina Riesner, Alexander Hackel, Lena F Schimke, Haroldo Dutra Dias, Igor Salerno Filgueiras, Helder I Nakaya, Niels Olsen Saraiva Camara, Stefan Fischer, Gabriela Riemekasten, Olle Ringdén, Olaf Penack, Tobias Winkler, Georg Duda, Dennyson Leandro M Fonseca, Otávio Ca
Opublikowane w: Stem Cells, 2024, ISSN 1066-5099
Wydawca: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxae054

The Pseudokinase TRIB1 in Immune Cells and Associated Disorders

Autorzy: Richard Danger, Yodit Feseha and Sophie Brouard
Opublikowane w: Cancers, 2022, Strona(/y) 14(4), ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14041011

Pretransplant Donor-specific IFNγ ELISPOT as a Predictor of Graft Rejection

Autorzy: Nuria Montero, Samira Farouk, Ilaria Gandolfini, Elena Crespo, Marta Jarque, Maria Meneghini, Alba Torija, Umberto Maggiore, Paolo Cravedi, Oriol Bestard
Opublikowane w: Transplantation Direct, Numer 5/5, 2019, Strona(/y) e451, ISSN 2373-8731
Wydawca: Wolters Kluwer Health, Inc
DOI: 10.1097/txd.0000000000000886

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation

Autorzy: François Brinas, Richard Danger and Sophie Brouard
Opublikowane w: Cells, 2021, Strona(/y) 10(6), ISSN 2073-4409
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells10061367

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

Autorzy: Esteban Cortes Garcia, Alessia Giarraputo, Maud Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, Marc Raynaud, Clément Couderau, Fariza Mezine, Jessie Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, Fabian Halleck, Magali Giral, Sophie Brouard, Richard Danger, Pierre-Antoine Gourraud, Marion Rabant, Lionel Couzi, Moglie Le Quintrec, Nassim Kamar, Emmanu
Opublikowane w: Transplant International, Numer 37, 2024, ISSN 1432-2277
Wydawca: Wiley
DOI: 10.3389/ti.2024.13043

Editorial: Emerging talents in alloimmunity and transplantation: 2022

Autorzy: Guido Moll, Wai H. Lim, Olaf Penack
Opublikowane w: Frontiers in Immunology, Numer 15, 2024, ISSN 1664-3224
Wydawca: Front. Immunol.
DOI: 10.3389/fimmu.2024.1393026

An exome-wide study of renal operational tolerance

Autorzy: Massart A*, Danger R*, Olsen C*, Emond M J, Viklicky O, Jacquemin V, Soblet J, Croes D, Perazzolo C, Hruba P, Daneels D, Caljon B, Sever M S, Pascual J, Pirson I, Ghisdal L, Smits G, Giral M, Abramowicz D, Abramowicz M and Brouard S
Opublikowane w: Frontiers in Medicine, Numer 17 May 2023 Sec. Nephrology Volume 9 - 2022, 2023, ISSN 2296-858X
Wydawca: -
DOI: 10.3389/fmed.2022.976248

FaDA: A web application for regular laboratory data analyses

Autorzy: Danger R, Moiteaux Q, Feseha Y, Geffard E, Ramstein G, Brouard S
Opublikowane w: PLoS One, 2021, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0261083

Secure distribution of Factor Analysis of Mixed Data (FAMD) and its application to personalized medicine of transplanted patients

Autorzy: S Sayadi, E Geffard, M Südholt, N Vince, PA Gourraud
Opublikowane w: Springer nature, 2021, ISSN 2509-4807
Wydawca: Springer
DOI: 10.1007/978-3-030-75100-5_44

Structural insights into the catalytic mechanism of granzyme B upon substrate and inhibitor binding

Autorzy: Tripathi N, Danger R, Chesneau M, Brouard S, Laurent AD
Opublikowane w: Journal of Molecular Graphics and Modelling, Numer 2022 Mar 22;114:108167, 2022, ISSN 1873-4243
Wydawca: ELSEVIER
DOI: 10.1016/j.jmgm.2022.108167

Prognostic Biomarkers in Kidney Transplantation: A Systematic Review and Critical Appraisal

Autorzy: Marc Raynaud, Solaf Al-Awadhi, Kevin Louis, Huanxi Zhang, Xiaojun Su, Valentin Goutaudier, Jiali Wang, Zeynep Demir, Yongcheng Wei, Agathe Truchot, Antoine Bouquegneau, Arnaud Del Bello, Élodie Bailly, Yannis Lombardi, Mehdi Maanaoui, Alessia Giarraputo, Sofia Naser, Gillian Divard, Olivier Aubert, Mohammad Hassan Murad, Changxi Wang, Longshan Liu, Oriol Bestard, Maarten Naesens, John J. Friedewa
Opublikowane w: Journal of the American Society of Nephrology, Numer 35, 2024, Strona(/y) 177-188, ISSN 1046-6673
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.0000000000000260

Blood Gene Signature as a Biomarker for Subclinical Kidney Allograft Rejection: Where Are We?

Autorzy: Christophe Masset, Richard Danger, Nicolas Degauque, Jacques Dantal, Magali Giral, Sophie Brouard
Opublikowane w: Transplantation, 2024, ISSN 0041-1337
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000005105

Editorial: Pharmacoeconomics in the era of health technology assessment and outcomes research to prioritize resource use, innovation and investmentwww.frontiersin.org

Autorzy: François R. Girardin1, Karen Cohen, Matthias Schwenkglenks, Isabelle Durand-Zaleski
Opublikowane w: Frontiers in Pharmacology, Numer 2023 May 16, 2023, Strona(/y) 14:1210002, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1210002

Relevance of the Banff Human Organ Transplant Consensus Gene Panel for Detecting Antibody and T-Cell–Mediated Rejection of Kidney Allografts

Autorzy: Alessia Giarraputo, Valentin Goutaudier, Blaise Robin, Annalisa Angelini, Marta Sablik, Olivier Aubert, Ivy A. Rosales, Rex N. Smith, Candice Roufosse, Benjamin Adam, Mark Haas, Robert B. Colvin, Carmen Lefaucheur, Michael Mengel, Dina Zielinski, Alexandre Loupy
Opublikowane w: Kidney International Reports, Numer 9, 2024, Strona(/y) 2290-2294, ISSN 2468-0249
Wydawca: Elsevier Inc.
DOI: 10.1016/j.ekir.2024.04.054