Bacterial persister regrowth

Informazioni relative al progetto

RESUSCITATION

ID dell’accordo di sovvenzione: 757369

DOI

10.3030/757369

Progetto concluso il 18 Ottobre 2019

Data della firma CE 5 Ottobre 2017

Data di avvio 1 Febbraio 2018

Data di completamento 31 Gennaio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 996,00

Contributo UE

€ 1 499 996,00

Coordinato da

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Periodic Reporting for period 2 - RESUSCITATION (Bacterial persister regrowth)

Periodo di rendicontazione: 2019-08-01 al 2021-01-31

Sintesi del contesto e degli obiettivi generali del progetto

Bacterial persisters are responsible for lack of clearance by antibiotic courses, leading to relapses of infection and recurrent treatments needed. We investigate how bacterial persisters resume growth and how toxins important for bacterial growth control lead to bacterial growth arrest, and how their activity can be reversed.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

We have deciphered the mode of action of three toxins, identified the specific target that they corrupt leading to bacterial self-intoxication. We have also deciphered fully how natural antitoxins neutralise the toxins, and can now mimic synthetically the naturalisation activity of the antitoxins.
We are investigating the ATP levels of persisters and the requirements of energy needed to allow dormant bacteria to resume growth (and lead to infection relapse).

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

We aim to provide a complete picture of what support and allow persister resuscitation as well as intervention startegies to prevent infection relapses.

Structures of three TacTs of Salmonella