Astrocyte-Neuronal Crosstalk in Obesity and Diabetes

Pubblicazioni

Hypothalamic astrocytes control systemic glucose metabolism and energy balance

Autori: Herrera Moro Chao, D., Kirchner, M.K., Pham, C., Foppen, E., Denis, R.G.P., Castel, J., Morel, C., Montalban, E., Hassouna, R., Bui, L.C., Renault, J., Mouffle, C., García-Cáceres, C., Tschöp, M.H., Li, D., Martin, C., Stern, J.E., Luquet, S.H.
Pubblicato in: Cell Metabolism, 2022, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2022.09.002

Astrocytic GABA in LHA is an obesity 'thermostat'

Autori: González-García I, García-Cáceres C.
Pubblicato in: Nature Metabolism, 2023, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-023-00849-0

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner

Autori: Luiza Maria Lutomska; Viktorian Miok; Natalie Krahmer; Ismael González García; Tim Gruber; Ophélia Le Thuc; Cahuê DB Murat; Beata Legutko; Michael Sterr; Gesine Saher; Heiko Lickert; Timo D. Müller; Siegfried Ussar; Matthias H. Tschöp; Dominik Lutter; Cristina García‐Cáceres
Pubblicato in: Glia 70, 2062-2078 (2022), Numero 4, 2022, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.24237

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Autori: Fabio Zani; Julianna Blagih; Tim Gruber; Michael D. Buck; Nicholas Jones; Marc Hennequart; Clare L. Newell; Steven E. Pilley; Pablo Soro-Barrio; Gavin Kelly; Nathalie M. Legrave; Eric C. Cheung; Ian S. Gilmore; Alex P. Gould; Cristina Garcia-Caceres; Karen H. Vousden
Pubblicato in: Nature, Numero 6, 2023, Pagina/e 705–711, ISSN 1476-4687
Editore: Springer Nature
DOI: 10.1038/s41586-023-05801-6

Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation

Autori: Milbank, E.* ; Dragano, N.R.V.* ; Gonzales García, I. ; Garcia, M.R.* ; Rivas-Limeres, V.* ; Perdomo, L.* ; Hilairet, G.* ; Ruiz-Pino, F.* ; Mallegol, P.* ; Morgan, D.A.* ; Iglesias-Rey, R.* ; Contreras, C.* ; Vergori, L.* ; Cuñarro, J.* ; Porteiro, B.* ; Gavaldà-Navarro, A.* ; Oelkrug, R.* ; Vidal, A.* ; Roa, J.* ; Sobrino, T.* ; Villarroya, F.* ; Diéguez, C.* ; Nogueiras, R.* ; García-Cáce
Pubblicato in: Nature metabolism, Numero Volume: 3, Numero: 10, 2021, Pagina/e 1415-1431, ISSN 2522-5812
Editore: Springer
DOI: 10.1038/s42255-021-00467-8

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Autori: Carmelo Quarta; Kerstin Stemmer; Aaron Novikoff; Bin Yang; Felix Klingelhuber; Alex Harger; Mostafa Bakhti; Aimee Bastidas-Ponce; Eric Baugé; Jonathan E. Campbell; Megan Capozzi; Christoffer Clemmensen; Gustav Collden; Perla Cota; Jon Douros; Daniel J. Drucker; Barent DuBois; Annette Feuchtinger; Cristina Garcia-Caceres; Gerald Grandl; Nathalie Hennuyer; Stephan Herzig; Susanna M. Hofmann; Patric
Pubblicato in: Nature Metabolism, Numero 7, 2022, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-022-00617-6

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

Autori: Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C
Pubblicato in: Cell Reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.113305

Insulin action on astrocytes: From energy homeostasis to behaviour

Autori: Ismael González‐García, Tim Gruber, Cristina García‐Cáceres
Pubblicato in: Journal of Neuroendocrinology, Numero 33/4, 2021, ISSN 0953-8194
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jne.12953

Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice

Autori: Ruth Karlina, Dominik Lutter, Viktorian Miok, David Fischer, Irem Altun, Theresa Schöttl, Kenji Schorpp, Andreas Israel, Cheryl Cero, James W Johnson, Ingrid Kapser-Fischer, Anika Böttcher, Susanne Keipert, Annette Feuchtinger, Elisabeth Graf, Tim Strom, Axel Walch, Heiko Lickert, Thomas Walzthoeni, Matthias Heinig, Fabian J Theis, Cristina García-Cáceres, Aaron M Cypess, Siegfried Ussar
Pubblicato in: Life Science Alliance, Numero 4/1, 2020, Pagina/e e202000924, ISSN 2575-1077
Editore: EMBO Press
DOI: 10.26508/lsa.202000924

Astrocyte Gliotransmission in the Regulation of Systemic Metabolism.

Autori: Cahuê De Bernardis Murat; Cristina García-Cáceres
Pubblicato in: Metabolites 11:732 (2021), Numero 1, 2021, Pagina/e 732, ISSN 2218-1989
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11110732

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

Autori: Francisco Javier Ruiz-Ojeda, Jiefu Wang, Theresa Bäcker, Martin Krueger, Samira Zamani, Simon Rosowski, Tim Gruber, Yasuhiro Onogi, Annette Feuchtinger, Tim J. Schulz, Reinhard Fässler, Timo D. Müller, Cristina García-Cáceres, Matthias Meier, Matthias Blüher, Siegfried Ussar
Pubblicato in: Molecular Metabolism, Numero 45, 2021, Pagina/e 101147, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101147

Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity.

Autori: Ismael González-García; Cristina García-Cáceres
Pubblicato in: Int. J. Mol. Sci. 22:6176 (2021), Numero 1, 2021, Pagina/e 6176, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126176

Synaptotagmin-13 is a neuroendocrine marker in brain, intestine and pancreas.

Autori: Tarquis Medina, M. ; Scheibner, K. ; Gonzales García, I. ; Bastidas-Ponce, A. ; Sterr, M. ; Jaki, J. ; Schirge, S. ; García-Cáceres, C. ; Lickert, H. ; Bakhti, M.
Pubblicato in: International Journal of Molecular Sciences, Numero Volume: 22, Numero: 22, Article Number: 12526, 2021, Pagina/e 12526, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222212526

Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome

Autori: Maity-Kumar, G., Ständer, L., de Angelis, M., Lee, S., Molenaar, A., Becker, L., Garrett, L., Amarie, O.V., Hölter, S.M., Wurst, W., Fuchs, H., Feuchtinger, A., Gailus-Durner, V., García-Cáceres, C., Othman, A.E., Brockmann, C., Schöffling, V.I., Beiser, K., Krude, H., Mroz, P.A., Hofmann, S.M., Tuckermann, J., DiMarchi, R.D., Hrabě de Angelis, M., Tschöp, M.H., Pfluger, P.T., Müller, T.D
Pubblicato in: Molecular Metabolism, 2022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101616

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Autori: Grandl G, Collden G, Feng J, Bhattacharya S, Klingelhuber F, Schomann L, Bilekova S, Ansarullah, Xu W, Far FF, Tost M, Gruber T, Bastidas-Ponce A, Zhang Q, Novikoff A, Liskiewicz A, Liskiewicz D, Garcia-Caceres C, Feuchtinger A, Tschöp MH, Krahmer N, Lickert H, Müller TD.
Pubblicato in: Nature Metabolism, 2024, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-024-00991-3

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Autori: Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Pubblicato in: Nature Neuroscience, Numero 22/1, 2019, Pagina/e 7-14, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-018-0286-y

Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice

Autori: Katrin Pfuhlmann, Sonja C. Schriever, Beata Legutko, Peter Baumann, Luke Harrison, Dhiraj G. Kabra, Emily Violette Baumgart, Matthias H. Tschöp, Cristina Garcia-Caceres, Paul T. Pfluger
Pubblicato in: Journal of Neuroinflammation, Numero 15/1, 2018, ISSN 1742-2094
Editore: BioMed Central
DOI: 10.1186/s12974-018-1076-x

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Autori: Dudek, M.* ; Pfister, D.* ; Donakonda, S.* ; Filpe, P.* ; Schneider, A.* ; Laschinger, M.* ; Hartmann, D.* ; Hüser, N.* ; Meiser, P.* ; Bayerl, F.* ; Inverso, D.* ; Wigger, J.* ; Sebode, M.* ; Öllinger, R.* ; Rad, R.* ; Hegenbarth, S.* ; Anton, M.* ; Guillot, A.* ; Bowman, A.* ; Heide, D.* ; Müller, F.* ; Ramadori, P.* ; Leone, V. ; García-Cáceres, C. ; Gruber, T. ; Seifert, G.* ; Kabat, A.M.
Pubblicato in: Nature, Numero Volume: 592, Numero: 7854,, 2021, Pagina/e 444-449, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03233-8

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Autori: Ismael González-García; Elena García-Clavé; Alberto Cebrian-Serrano; Ophélia Le Thuc; Raian E. Contreras; Yanjun Xu; Tim Gruber; Sonja C. Schriever; Beata Legutko; Jutta Lintelmann; Jerzy Adamski; Wolfgang Wurst; Timo D. Müller; Stephen C. Woods; Paul T. Pfluger; Matthias H. Tschöp; Alexandre Fisette; Cristina García-Cáceres
Pubblicato in: Cell metabolism 35(3), 438 - 455.e7 (2023). doi:10.1016/j.cmet.2023.02.004, Numero 8, 2023, Pagina/e 438 - 455, ISSN 1932-7420
Editore: Elsevier
DOI: 10.1016/j.cmet.2023.02.004

Astroglial clean-up of satiety synapses

Autori: Tim Gruber, Cristina García-Cáceres
Pubblicato in: Nature Metabolism, Numero 4, pages 505–506 (2022), 2022, Pagina/e 505–506, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-022-00563-3

Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice

Autori: D. Liskiewicz; Q. Zhang; C.S. Barthem; M. Jastroch; A. Liskiewicz; N. Khajavi; G. Grandl; C. Coupland; M. Kleinert; C. Garcia-Caceres; A. Novikoff; G. Maity; U. Boehm; M.H. Tschöp; T.D. Müller
Pubblicato in: Mol Metab, Numero 5, 2023, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101714

Divide et impera: How mitochondrial fission in astrocytes rules obesity

Autori: Ismael González-García, Ophélia Le Thuc, Martin Jastroch, Cristina García-Cáceres
Pubblicato in: Molecular Metabolism, Numero 45, 2021, Pagina/e 101159, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101159

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Autori: Zhang, Q. ; Delessa, C.T.* ; Augustin, R.* ; Bakhti, M. ; Collden, G. ; Drucker, D.J.* ; Feuchtinger, A. ; García-Cáceres, C. ; Grandl, G. ; Harger, A. ; Herzig, S. ; Hofmann, S.M. ; Holleman, C.L. ; Jastroch, M.* ; Keipert, S.* ; Kleinert, M. ; Knerr, P.J.* ; Kulaj, K. ; Legutko, B. ; Lickert, H. ; Liu, X. ; Luippold, G.* ; Lutter, D. ; Malogajski, E. ; Tarquis Medina, M. ; Mowery, S.A.* ; Blut
Pubblicato in: Cell Metabolism, Numero Volume: 33, Numero: 4, Pages: 833-844.e5, 2021, Pagina/e 833-844, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.01.015

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

Autori: Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahuê De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, María de la Fuente-Fernández, Angel Luis García-Villalón, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Er
Pubblicato in: Cell Metabolism, Numero 33/6, 2021, Pagina/e 1155-1170.e10, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.04.007

Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner

Autori: González-Vila A, Luengo-Mateos M, Silveira-Loureiro M, Garrido-Gil P, Ohinska N, González-Domínguez M, Labandeira-García JL, García-Cáceres C, López M, Barca-Mayo O.
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44039-8

The Neuroanatomical Organization of Hypothalamic Feeding Circuits

Autori: Tim Gruber, Stephen C. Woods, Matthias H. Tschöp & Cristina García-Cáceres
Pubblicato in: Neuroanatomy of Neuroendocrine Systems. Masterclass in Neuroendocrinology, Numero vol. 12, 2022, Pagina/e 317–346, ISSN 2662-2068
Editore: Springer Nature
DOI: 10.1007/978-3-030-86630-3_12

Control of Systemic Metabolism by Astrocytes in the Brain

Autori: Ophélia Le Thuc, Tim Gruber, Matthias H. Tschöp, Cristina García-Cáceres
Pubblicato in: Glial-Neuronal Signaling in Neuroendocrine Systems, Numero 11, 2021, Pagina/e 127-153, ISBN 978-3-030-62382-1
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-62383-8_6

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