Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

Informazioni relative al progetto

enzC-Hem

ID dell’accordo di sovvenzione: 757991

DOI 10.3030/757991

Progetto chiuso

Data della firma CE 13 Novembre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 31 Dicembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 492 424,00

Contributo UE € 1 492 424,00

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

Pubblicazioni

Peer reviewed articles (9)

Insights into the H2O2-driven catalytic mechanism of fungal lytic polysaccharide monooxygenases

Autori: Tobias M. Hedison; Erik Breslmayr; Erik Breslmayr; Muralidharan Shanmugam; Kwankao Karnpakdee; Derren J. Heyes; Anthony P. Green; Roland Ludwig; Nigel S. Scrutton; Daniel Kracher; Daniel Kracher
Pubblicato in: Hedison , T M , Breslmayr , E , Shanmugam , M , Karnpakdee , K , Heyes , D J , Green , A P , Ludwig , R , Scrutton , N S & Kracher , D 2020 , ' Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases ' , The FEBS Journal . https://doi.org/10.1111/febs.15704, Numero 17424658, 2021, ISSN 1742-4658
Editore: Wiley
DOI: 10.1111/febs.15704

Enzymes with noncanonical amino acids

Autori: Jingming Zhao, Ashleigh J. Burke, Anthony P. Green
Pubblicato in: Current Opinion in Chemical Biology, Numero 55, 2020, Pagina/e 136-144, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2020.01.006

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Autori: Mary Ortmayer; Florence J. Hardy; Matthew G. Quesne; Matthew G. Quesne; Karl Fisher; Colin Levy; Derren J. Heyes; C. Richard A. Catlow; C. Richard A. Catlow; C. Richard A. Catlow; Sam P. de Visser; Stephen E. J. Rigby; Sam Hay; Anthony P. Green
Pubblicato in: 2691-3704, Numero 26913704, 2021, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.1c00145

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

Autori: Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green
Pubblicato in: ACS Catalysis, Numero 10/4, 2020, Pagina/e 2735-2746, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.9b05129

Engineered Metalloenzymes with Non‐Canonical Coordination Environments

Autori: Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Pubblicato in: Chemistry – A European Journal, Numero 24/46, 2018, Pagina/e 11821-11830, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800975

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Autori: Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Pubblicato in: Nature, Numero 570/7760, 2019, Pagina/e 219-223, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1262-8

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Autori: Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
Pubblicato in: Journal of the American Chemical Society, Numero 140/4, 2018, Pagina/e 1535-1543, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b12621

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Autori: Jin Xu, Anthony P. Green, Nicholas J. Turner
Pubblicato in: Angewandte Chemie International Edition, Numero 57/51, 2018, Pagina/e 16760-16763, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Autori: Ashleigh J. Burke; William R. Birmingham; Ying Zhuo; Thomas W. Thorpe; Bruna Zucoloto da Costa; Rebecca Crawshaw; Ian Rowles; James D. Finnigan; Carl Young; Gregory M. Holgate; Mark P. Muldowney; Simon J. Charnock; Sarah L. Lovelock; Nicholas J. Turner; Anthony P. Green
Pubblicato in: Crossref, Numero 26913704, 2022, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacs.1c11048

Non-peer reviewed articles (1)

A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer

Autori: Anthony Green; Jonathan Trimble; Rebecca Crawshaw; Florence Hardy; Colin Levy; Murray Brown; Douglas Fuerst; Derren Heyes; Richard Obexer
Pubblicato in: Crossref, Numero 25732293, 2022, ISSN 2573-2293
Editore: Cambridge University Press
DOI: 10.21203/rs.3.rs-1650767/v1