The genetic basis of the convergent evolution of fungal multicellularity

Project Information

Multicellularity

Grant agreement ID: 758161

DOI

10.3030/758161

Project closed

EC signature date 24 October 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 486 500,00

EU contribution

€ 1 486 500,00

Coordinated by

HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (17)

Revealing tissue-specific developmental trajectories in fruiting bodies of Coprinopsis cinerea by single-cell RNA sequencing.

Author(s): Varga T., Bálint B., Bense V., Nagy GL
Published in: 2020
Publisher: 15th European Conference on Fungal Genetics

Fungal multicellularity and fruiting body development, from a transcriptomic and genomic perspective.

Author(s): László G Nagy
Published in: 2020
Publisher: Israel Molecular Mycology Meeting

Development of Single and Multitargeted Gene Deletion Methods in the Inky-Cap Fungus Coprinopsis cinerea

Author(s): Csernetics A., Viragh M., Bense V., Trenka V., Pal P., Nagy GL.
Published in: 2020
Publisher: 15th European Conference on Fungal Genetics

Towards understanding conserved gene regulatory networks in fungi: an update on the FUNCODE Project.

Author(s): László G Nagy
Published in: 2021
Publisher: Botany 2021

Allele specific expression during fruiting body formation in Pleurotus ostreatus.

Author(s): Zsolt Merényi, Máté Virágh, Emile Gluck-Thaler, Jason C. Slot, Brigitta Kiss, Torda Varga, András Geösel, Botond Hegedüs, Balázs Bálint, László G. Nagy
Published in: 2022
Publisher: 31st Fungal Genetics Conference

RNA-seq of cell populations during the early development of Coprinopsis cinerea reveals intensive reprogramming of hyphal growth patterns.

Author(s): Varga T., Bálint B., Bense V., Nagy GL.
Published in: 2020
Publisher: Meeting of the Mycological Society of America

Taxonomic vs. genomic fungi: large turnover of protistan genetic heritage in the fungal kingdom.

Author(s): László G. Nagy, Zsolt Merényi
Published in: 2022
Publisher: Jacques Monod Conferences: The origin of Metazoans

FGC Evolution repeats itself in fungal morphogenetic transitions - in search of mechanisms of convergent evolution

Author(s): László G Nagy
Published in: 2022
Publisher: 31st Fungal Genetics Conference

A macro-evolutionary perspective on long-distance mass transport in fungi.

Author(s): Varga T., Bense V., Nagy GL.
Published in: 2020
Publisher: 15th European Conference on Fungal Genetics

Omics’ approaches of fruiting body development for improving commercial mushroom strains

Author(s): László G. Nagy
Published in: 2021
Publisher: ISMS e-Congress

Unmatched level of molecular convergence among deeply divergent complex multicellular fungi.

Author(s): Merenyi Zs., Prasanna AN., Wang Z., Kovacs K., Hegedus B., Balint B., Papp B., Townsend JP., Nagy GL
Published in: EVOLUTION of COMPLEX LIFE, Issue 15-17. May 2019., 2019
Publisher: Georgia Tech

The Origins of Complex Multicellularity in Agarico- and Pezizomycotina.

Author(s): Merenyi Zs., Prasanna AN., Almasi E., Krizsan K., Nagy GL.
Published in: A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium, Issue 17-19. October 2018, 2018
Publisher: Magyar Mikrobiológiai Társaság

Comparative genomics reveals the origin of hyphal morphogenesis and fungal multicellularity.

Author(s): Kiss E., Hegedus B., Varga T., Merenyi Zs., Balint B., Koszo T., Krizsan K., Prasanna AN., Nagy GL.
Published in: 30th Fungal Genetics Conference, Issue 12-17. March. 2019., 2019, Page(s) p.15.
Publisher: Genetics Society of America

Evolutionary analysis of thousands of genomes with COMPARE1K+.

Author(s): Balint B., Merenyi Zs., Varga T., Grigoriev IV., Nagy GL.
Published in: NeLLi – Symposium on New Lineages of Life, Issue 2-3. April 2019., 2019
Publisher: DOE Joist Genome Institue

COMPARE1K+, a bioinformatic pipeline and an R package to analyse the evolution of thousands of genomes

Author(s): Varga T., Balint B., Merenyi Zs., Grigoriev IV., Nagy GL.
Published in: Hungarian Molecular Life Science, Issue 29-31. March. 2019., 2019, Page(s) p.245.
Publisher: MBKE, MAGE

Understanding the evolution of mushroom-forming fungi: macro-evolutionary analyses of a 5300-species phylogeny of Agaricomycetes.

Author(s): Varga T., Krizsan K., Szarkandi GJ, Dima B., Kiss B., Foldi Cs., Sanchez-Garcia M., Sanchez-Ramirez S., Szollosi GJ., M., Hibbett DS., Vagvolgyi Cs., Papp T., Nagy GL.
Published in: 14th European Conference on Fungal Genetics, Issue 25-28. February. 2018., 2018, Page(s) p.104.
Publisher: ECFG14

Patterns of genome evolution underlying differential wood-decay mechanisms in Polyporales.

Author(s): Virágh M., Merényi, Zs. , Bálint, B., Hage, H., Miyauchi, S., Favel S., Miettinen O., Grigoriev, IV., Rosso, MN., Martin F., Nagy GL.
Published in: 2019
Publisher: Asian Mycological Congress

Peer reviewed articles (19)

Fruiting body form, not nutritional mode, is the major driver of diversification in mushroom-forming fungi

Author(s): Marisol Sánchez-García, Martin Ryberg, Faheema Kalsoom Khan, Torda Varga, László G. Nagy, David S. Hibbett
Published in: Proceedings of the National Academy of Sciences, Issue 117/51, 2020, Page(s) 32528-32534, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1922539117

Genomes of fungi and relatives reveal delayed loss of ancestral gene families and evolution of key fungal traits

Author(s): Zsolt Merényi, Krisztina Krizsán, Neha Sahu, Xiao-Bin Liu, Balázs Bálint, Jason E. Stajich, Joseph W. Spatafora, László G. Nagy
Published in: Nature Ecology and Evolution, 2023, ISSN 2397-334X
Publisher: Nature Portfolio
DOI: 10.1038/s41559-023-02095-9

Comparative genomics reveals unique wood‐decay strategies and fruiting body development in the Schizophyllaceae

Author(s): Éva Almási, Neha Sahu, Krisztina Krizsán, Balázs Bálint, Gábor M. Kovács, Brigitta Kiss, Judit Cseklye, Elodie Drula, Bernard Henrissat, István Nagy, Mansi Chovatia, Catherine Adam, Kurt LaButti, Anna Lipzen, Robert Riley, Igor V. Grigoriev, László G. Nagy
Published in: New Phytologist, Issue 224/2, 2019, Page(s) 902-915, ISSN 0028-646X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nph.16032

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Author(s): László G. Nagy, Peter Jan Vonk, Markus Künzler, Csenge Földi, Máté Virágh, Robin A. Ohm, Florian Hennicke, Balázs Bálint, Árpád Csernetics, Botond Hegedüs, Zhihao Hou, Xiao-Bin Liu, Shen Nan, Manish Pareek, Neha Sahu, Benedek Szathmári, Torda Varga, Hongli Wu, Xiao Yang, Zsolt Merényi
Published in: Studies in Mycology, 2022, ISSN 0166-0616
Publisher: Centraal Bureau voor Schimmelculturals
DOI: 10.1101/2021.12.09.471732

Vertical and horizontal gene transfer shaped plant colonization and biomass degradation in the fungal genus Armillaria

Author(s): Neha Sahu, Boris Indic, Johanna Wong-Bajracharya, Zsolt Merényi, Huei-Mien Ke, Steven Ahrendt, Tori-Lee Monk, Sándor Kocsubé, Elodie Drula, Anna Lipzen, Balázs Bálint, Bernard Henrissat, Bill Andreopoulos, Francis M. Martin, Christoffer Bugge Harder, Daniel Rigling, Kathryn L. Ford, Gary D. Foster, Jasmyn Pangilinan, Alexie Papanicolaou, Kerrie Barry, Kurt LaButti, Máté Virágh, Maxim Koria
Published in: Nature Microbiology, Issue 8, 2023, Page(s) pages 1668–1681, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-023-01448-1

Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

Author(s): Zsolt Merényi, Máté Virágh, Emile Gluck-Thaler, Jason C Slot, Brigitta Kiss, Torda Varga, András Geösel, Botond Hegedüs, Balázs Bálint, László G Nagy
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71348

Evolutionary Morphogenesis of Sexual Fruiting Bodies in Basidiomycota: Toward a New Evo-Devo Synthesis

Author(s): Máté Virágh, Zsolt Merényi, Árpád Csernetics, Csenge Földi, Neha Sahu, Xiao-Bin Liu, David S. Hibbett, László G. Nagy
Published in: Microbiology and Molecular Biology Reviews, 2021, ISSN 1092-2172
Publisher: American Society for Microbiology
DOI: 10.1128/mmbr.00019-21

Radiation of mushroom-forming fungi correlates with novel modes of protecting sexual fruiting bodies

Author(s): Torda Varga, Csenge Földi, Viktória Bense, László G. Nagy
Published in: Fungal Biology, 2022, ISSN 1878-6146
Publisher: Elsevier BV
DOI: 10.1016/j.funbio.2022.07.001

Mycology: Rediscovery of a lost model fungus highlights the origin of mycorrhizal symbioses

Author(s): László G.Nagy, Gábor M.Kovács
Published in: Current Biology, 2021, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.02.006

Hallmarks of Basidiomycete Soft- and White-Rot in Wood-Decay -Omics Data of Two Armillaria Species

Author(s): Neha Sahu, Zsolt Merényi, Balázs Bálint, Brigitta Kiss, György Sipos, Rebecca A. Owens, László G. Nagy
Published in: Microorganisms, Issue 9/1, 2021, Page(s) 149, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9010149

Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi

Author(s): Krisztina Krizsán, Éva Almási, Zsolt Merényi, Neha Sahu, Máté Virágh, Tamás Kószó, Stephen Mondo, Brigitta Kiss, Balázs Bálint, Ursula Kües, Kerrie Barry, Judit Cseklye, Botond Hegedüs, Bernard Henrissat, Jenifer Johnson, Anna Lipzen, Robin A. Ohm, István Nagy, Jasmyn Pangilinan, Juying Yan, Yi Xiong, Igor V. Grigoriev, David S. Hibbett, László G. Nagy
Published in: Proceedings of the National Academy of Sciences, Issue 116/15, 2019, Page(s) 7409-7418, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1817822116

Comparative genomics reveals the origin of fungal hyphae and multicellularity

Author(s): Enikő Kiss, Botond Hegedüs, Máté Virágh, Torda Varga, Zsolt Merényi, Tamás Kószó, Balázs Bálint, Arun N. Prasanna, Krisztina Krizsán, Sándor Kocsubé, Meritxell Riquelme, Norio Takeshita, László G. Nagy
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12085-w

Many roads to convergence

Author(s): Nagy, GL.
Published in: Science, Issue 361/6398, 2018, Page(s) 125-126, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau2409

Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi

Author(s): Zsolt Merényi, Arun N Prasanna, Zheng Wang, Károly Kovács, Botond Hegedüs, Balázs Bálint, Balázs Papp, Jeffrey P Townsend, László G Nagy
Published in: Molecular Biology and Evolution, 2020, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa077

Novel phylogenetic methods are needed for understanding gene function in the era of mega-scale genome sequencing

Author(s): László G Nagy, Zsolt Merényi, Botond Hegedüs, Balázs Bálint
Published in: Nucleic Acids Research, Issue 48/5, 2020, Page(s) 2209-2219, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz1241

Model Choice, Missing Data, and Taxon Sampling Impact Phylogenomic Inference of Deep Basidiomycota Relationships

Author(s): Arun N Prasanna, Daniel Gerber, Teeratas Kijpornyongpan, M Catherine Aime, Vinson P Doyle, Laszlo G Nagy
Published in: Systematic Biology, Issue 69/1, 2019, Page(s) 17-37, ISSN 1063-5157
Publisher: Taylor & Francis
DOI: 10.1093/sysbio/syz029

Megaphylogeny resolves global patterns of mushroom evolution

Author(s): Torda Varga, Krisztina Krizsán, Csenge Földi, Bálint Dima, Marisol Sánchez-García, Santiago Sánchez-Ramírez, Gergely J. Szöllősi, János G. Szarkándi, Viktor Papp, László Albert, William Andreopoulos, Claudio Angelini, Vladimír Antonín, Kerrie W. Barry, Neale L. Bougher, Peter Buchanan, Bart Buyck, Viktória Bense, Pam Catcheside, Mansi Chovatia, Jerry Cooper, Wolfgang Dämon, Dennis
Published in: Nature Ecology & Evolution, Issue 3/4, 2019, Page(s) 668-678, ISSN 2397-334X
Publisher: Springer Nature
DOI: 10.1038/s41559-019-0834-1

Preassembled Cas9 Ribonucleoprotein-Mediated Gene Deletion Identifies the Carbon Catabolite Repressor and Its Target Genes in Coprinopsis cinerea

Author(s): Manish Pareek, Botond Hegedüs, Zhihao Hou, Árpád Csernetics, Hongli Wu, Máté Virágh, Neha Sahu, Xiao-Bin Liu, László Nagy
Published in: Applied and Environmental Microbiology, 2022, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.00940-22

Fungi took a unique evolutionary route to multicellularity: Seven key challenges for fungal multicellular life

Author(s): László G. Nagy, Torda Varga, Árpád Csernetics, Máté Virágh
Published in: Fungal Biology Reviews, Issue 34/4, 2020, Page(s) 151-169, ISSN 1749-4613
Publisher: Elsevier BV
DOI: 10.1016/j.fbr.2020.07.002