Molecular mechanisms of interferon-induced antiviral restriction and signalling

Informazioni relative al progetto

ANTIViR

ID dell’accordo di sovvenzione: 759226

DOI 10.3030/759226

Progetto chiuso

Data della firma CE 14 Novembre 2017

Data di avvio 1 Dicembre 2017

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 793,77

Contributo UE € 1 499 793,77

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Pubblicazioni

Peer reviewed articles (10)

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Autori: Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadão, Lowiese Desmarets, Mary Arnaud-Arnould, Yves Rouillé, Marine Tauziet, Donatella Giovannini, Jawida Touhami, Yenarae Lee, Peter DeWeirdt, Mudra Hegde, Serge Urbach, Khadija El Koulali, Francisco Garcia de Gracia, Joe McKellar, Jean Dubuisson, Mélanie Wencker, Sandrine Belouzard, Olivier Moncorgé, John G. Doench and C
Pubblicato in: Nature Genetics, 2022, ISSN 1546-1718
Editore: NPG
DOI: 10.1038/s41588-022-01110-2

Crystal structure of the TLDc domain of human NCOA7-AS.

Autori: Mary Arnaud-Arnould; Marine Tauziet; Olivier Moncorgé; Caroline Goujon; Mickaël Blaise
Pubblicato in: Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS, Numero 2, 2021, ISSN 2053-230X
Editore: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x21006853

DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections

Autori: Boris Bonaventure, Caroline Goujon
Pubblicato in: Journal of General Virology, 2022, ISSN 1465-2099
Editore: Microbiology Society
DOI: 10.1099/jgv.0.001766

Clash of the titans: interferons and SARS-CoV-2

Autori: Nolwenn Jouvenet, Caroline Goujon, Arinjay Banerjee
Pubblicato in: Trends in Immunology, 2021, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2021.10.009

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Autori: Rémi Planès, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadão, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michèle Tiraby, COVID Human Genetic Effort; Qian Zhang, Pietro Cicuta, Emmanuelle Jouan
Pubblicato in: Molecular Cell, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.04.033

The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry

Autori: Tomas Doyle, Olivier Moncorgé, Boris Bonaventure, Darja Pollpeter, Marion Lussignol, Marine Tauziet, Luis Apolonia, Maria-Teresa Catanese, Caroline Goujon, Michael H. Malim
Pubblicato in: Nature Microbiology, Numero 3/12, 2018, Pagina/e 1369-1376, ISSN 2058-5276
Editore: Springer Nature
DOI: 10.1038/s41564-018-0273-9

Mammalian and Avian Host Cell Influenza A Restriction Factors

Autori: Joe McKellar, Antoine Rebendenne, Mélanie Wencker, Olivier Moncorgé, Caroline Goujon
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030522

The <scp>DEAD</scp> box <scp>RNA</scp> helicase <scp>DDX42</scp> is an intrinsic inhibitor of positive‐strand <scp>RNA</scp> viruses

Autori: Boris Bonaventure; Antoine Rebendenne; Ana Luiza Chaves Valadão; Mary Arnaud‐Arnould; Ségolène Gracias; Francisco Garcia de Gracia; Joe McKellar; Emmanuel Labaronne; Marine Tauziet; Valérie Vivet‐Boudou; Eric Bernard; Laurence Briant; Nathalie Gros; Wassila Djilli; Valérie Courgnaud; Hugues Parrinello; Stéphanie Rialle; Mickaël Blaise; Laurent Lacroix; Marc Lavigne; Jean‐Christophe Pa
Pubblicato in: EMBO reports, 2022, ISSN 1469-3178
Editore: Wiley
DOI: 10.15252/embr.202154061

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

Autori: Antoine Rebendenne, Ana Luiza Chaves Valadao, Marine Tauziet, Ghizlane Maarifi, Boris Bonaventure, Joe McKellar, Sébastien Nisole, Mary Arnaud-Arnould, Olivier Moncorgé, Caroline Goujon
Pubblicato in: Journal of Virology, 2021, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.02415-20

An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses

Autori: Joe McKellar, Mary Arnaud-Arnould, Laurent Chaloin, Marine Tauziet, Charlotte Arpin-André, Oriane Pourcelot, Mickaël Blaise, Olivier Moncorgé, and Caroline Goujon
Pubblicato in: Journal of Biological Chemistry, 2023, ISSN 1083-351X
Editore: American Society for Biochemistry and Molecular Biology, Inc.
DOI: 10.1016/j.jbc.2022.102747

Other (1)

Human MX1 induces the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

Autori: Joe McKellar, Francisco García de Gracia, Corentin Aubé, Ana Luiza Chaves Valadão, Marine Tauziet, Mary Arnaud-Arnould, Antoine Rebendenne, Aymeric Neyret, Emmanuel Labaronne, Emiliano P. Ricci, Bénédicte Delaval, Raphael Gaudin, Nadia Naffakh, Sarah Gallois-Montbrun, Olivier Moncorgé, Caroline Goujon
Pubblicato in: bioRxiv, 2024
Editore: bioRxiv