Advancing cell based therapies by supporting implant survival

Informazioni relative al progetto

ENABLE

ID dell’accordo di sovvenzione: 759425

DOI 10.3030/759425

Progetto chiuso

Data della firma CE 7 Settembre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 30 Giugno 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

UNIVERSITEIT TWENTE
Netherlands

Pubblicazioni

Peer reviewed articles (20)

A Modular Platform for Cytocompatible Hydrogels with Tailored Mechanical Properties Based on Monolithic Matrices and Particulate Building Blocks

Autori: Lea Andrée; Pascal Bertsch; Rong Wang; Malin Becker; Jeroen Leijten; Peter Fischer; Fang Yang; Sander C. G. Leeuwenburgh
Pubblicato in: ACS Biomacromolecules, 2023, ISSN 1526-4602
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.3c00177

Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants

Autori: Ali Farzin; Ali Farzin; Shabir Hassan; Liliana Moreira Teixeira; Melvin Gurian; João F. Crispim; Varun Manhas; Aurélie Carlier; Hojae Bae; Liesbet Geris; Iman Noshadi; Su Ryon Shin; Jeroen Leijten; Jeroen Leijten
Pubblicato in: VOLUME=31;ISSUE=42;ISSN=1616-301X;TITLE=Advanced Functional Materials, Numero 3, 2021, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202100850

Aqueous Two-Phase Enabled Low Viscosity 3D (LoV3D) Bioprinting of Living Matter

Autori: Malin Becker; Melvin Gurian; Maik Schot; Jeroen Leijten
Pubblicato in: Advanced science, Numero 1, 2022, Pagina/e 10(8):2204609, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202204609

Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells

Autori: Shabir Hassan, Ting Wang, Kun Shi, Yike Huang, Maria Elizabeth Urbina Lopez, Kaifeng Gan, Mo Chen, Niels Willemen, Haroon Kalam, Eder Luna-Ceron, Berivan Cecen, Gihan Daw Elbait, Jinghang Li, Luis Enrique Garcia-Rivera, Melvin Gurian, Mudassir Meraj Banday, Kisuk Yang, Myung Chul Lee, Weida Zhuang, Castro Johnbosco, Oju Jeon, Eben Alsberg, Jeroen Leijten*, and Su Ryon Shin*.
Pubblicato in: Biomaterials, 2023, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122179

Scalable fabrication, compartmentalization and applications of living microtissues

Autori: Maik Schot; Nuno Araújo-Gomes; Bas van Loo; Tom Kamperman; Jeroen Leijten
Pubblicato in: Bioactive Materials, Numero 1, 2022, ISSN 2452-199X
Editore: KeAi Publishing Communications Ltd.
DOI: 10.1016/j.bioactmat.2022.04.005

Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli‐Responsive Cell‐Adhesive Micromaterials

Autori: Tom Kamperman; Niels G. A. Willemen; Cindy Kelder; Michelle Koerselman; Malin Becker; Luanda Lins; Castro Johnbosco; Marcel Karperien; Jeroen Leijten
Pubblicato in: Advance Science, Numero 1, 2022, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202205487

Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics

Autori: Tom Kamperman, Vasileios D. Trikalitis, Marcel Karperien, Claas Willem Visser, Jeroen Leijten
Pubblicato in: ACS Applied Materials & Interfaces, Numero 10/28, 2018, Pagina/e 23433-23438, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.8b05227

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Autori: Elahe Hadavi, Jeroen Leijten, Jenny Brinkmann, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn
Pubblicato in: Tissue Engineering Part C: Methods, Numero 24/11, 2018, Pagina/e 628-636, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0151

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Autori: Tom Kamperman, Bas van Loo, Melvin Gurian, Sieger Henke, Marcel Karperien, Jeroen Leijten
Pubblicato in: Lab on a Chip, Numero 19/11, 2019, Pagina/e 1977-1984, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/c9lc00054b

Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions

Autori: Jungmok Seo, Jung-Youn Shin, Jeroen Leijten, Oju Jeon, Ayça Bal Öztürk, Jeroen Rouwkema, Yuancheng Li, Su Ryon Shin, Hadi Hajiali, Eben Alsberg, Ali Khademhosseini
Pubblicato in: ACS Applied Materials & Interfaces, Numero 10/16, 2018, Pagina/e 13293-13303, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.7b17991

Single-Cell Microgels: Technology, Challenges, and Applications

Autori: Tom Kamperman, Marcel Karperien, Séverine Le Gac, Jeroen Leijten
Pubblicato in: Trends in Biotechnology, Numero 36/8, 2018, Pagina/e 850-865, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2018.03.001

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

Autori: Elahe Hadavi, Jeroen Leijten, Marten Engelse, Eelco de Koning, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn
Pubblicato in: Tissue Engineering Part C: Methods, Numero 25/2, 2019, Pagina/e 71-81, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0336

3D Printed Cartilage‐Like Tissue Constructs with Spatially Controlled Mechanical Properties

Autori: Bruna A. G. Melo, Yasamin A. Jodat, Shreya Mehrotra, Michelle A. Calabrese, Tom Kamperman, Biman B. Mandal, Maria H. A. Santana, Eben Alsberg, Jeroen Leijten, Su Ryon Shin
Pubblicato in: Advanced Functional Materials, Numero 29/51, 2019, Pagina/e 1906330, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201906330

Engineering 3D parallelized microfluidic droplet generators with equal flow profiles by computational fluid dynamics and stereolithographic printing

Autori: Tom Kamperman, Liliana Moreira Teixeira, Seyedeh Sarah Salehi, Greet Kerckhofs, Yann Guyot, Mike Geven, Liesbet Geris, Dirk Grijpma, Sebastien Blanquer, Jeroen Leijten
Pubblicato in: Lab on a Chip, Numero 20/3, 2020, Pagina/e 490-495, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/c9lc00980a

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Autori: Tom Kamperman, Michelle Koerselman, Cindy Kelder, Jan Hendriks, João F. Crispim, Xandra de Peuter, Pieter J. Dijkstra, Marcel Karperien, Jeroen Leijten
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-12390-4

Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation

Autori: B. van Loo, S.S. Salehi, S. Henke, A. Shamloo, T. Kamperman, M. Karperien, J. Leijten
Pubblicato in: Materials Today Bio, Numero 6, 2020, Pagina/e 100047, ISSN 2590-0064
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mtbio.2020.100047

Enzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials

Autori: Niels G. A. Willemen; Shabir Hassan; Melvin Gurian; Maria Fernanda Jasso‐Salazar; Kai Fan; Haihang Wang; Malin Becker; Iris E. Allijn; Ayça Bal‐Öztürk; Jeroen Leijten; Su Ryon Shin
Pubblicato in: Advanced healthcare materials, 11(13):2102697. Wiley, Numero 1, 2022, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202102697

Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules

Autori: Bas van Loo, Simone A. ten Den, Nuno Araújo-Gomes, Vincent de Jong, Rebecca R. Snabel, Maik Schot, José M. Rivera-Arbeláez, Gert Jan C. Veenstra, Robert Passier, Tom Kamperman, and Jeroen Leijten
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42297-0

Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non-Cell-Adhesive Materials.

Autori: Tom Kamperman; Tom Kamperman; Sieger Henke; João F. Crispim; Niels G A Willemen; Pieter J. Dijkstra; Wooje Lee; Herman L. Offerhaus; Martin Peter Neubauer; Alexandra M. Smink; Paul de Vos; Bart J. de Haan; Marcel Karperien; Su Ryon Shin; Jeroen Leijten
Pubblicato in: Advanced Materials, Numero 2, 2021, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202102660

Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules

Autori: Gilles S. van Tienderen, Jorke Willemse, Bas van Loo, Eline V. A. van Hengel,Jeroen de Jonge,Luc J. W. van der Laan, Jeroen Leijten, and Monique M. A. Verstegen
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11223657