Risultati finali Documents, reports (5) Prioritised methods and their reproducibility for intrinsic physicochemical properties Methodical guidance on physicochemical characterization for grouping and read-across purposes. This includes a proof of reproducibility on benchmark materials between the lead lab and the backup labs for each property. Report of the NMs/NFs, NEPs and released NMs/NFs supplied to other WPs Table of NMs, NFs NEP and released NMs/NFs distributed to WP3, 4 and 5 for characterization / testing. Guidance Document A Guidance Document detailing the entire Framework and its individual components will be generated It will provide details of how to conduct grouping and use the results for readacross for risk assessment andor classification The Guidance Document will further detail how the software module cf Task 67 can be employed in current risk assessment and management tools eg SUN DSS GUIDEnano Tool Data curation system Interim deliverable due month 12 and 24Data curation system based on the eNanoMapper database with tools for data curation and ontology mapping Requirements for data quality criteria, data sources, modelling tools and terminology Interim deliverable due month 6 and 18This report describes the criteria and requirements for data quality terminology and modelling to be incorporated in the GRACIOUS Framework Other (1) Stakeholder events, training and conference Interim deliverable due month 6 and 27We will have three stakeholder events together with WP1 to gather feedback on the development of the tool We will also run two training schools if possible together with other EC funded initiatives to transfer knowledge to the next generation of researchers and a final event to disseminate the projects results to stakeholders Pubblicazioni Peer reviewed articles (20) Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow 1 cells: The case of barium sulfate Autori: Keller, Johannes G.; Graham, Uschi; Koltermann-Jülly, Johanna; Gelein, Robert; Ma-Hock, Lan; Landsiedel, Robert; Wiemann, Martin; Oberdörster, Günter; Alison Elder; Wohlleben, Wendel Pubblicato in: Scientific Reports, Issue 458 (2020), 2020, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.5281/zenodo.3239013 Understanding Dissolution Rates via Continuous Flow Systems with Physiologically Relevant Metal Ion Saturation in Lysosome Autori: Johannes Keller, Willie Peijnenburg, Kai Werle, Robert Landsiedel, Wendel Wohlleben Pubblicato in: Nanomaterials, Issue 10/2, 2020, Page(s) 311, ISSN 2079-4991 Editore: Multidisciplinary Digital Publishing Institute DOI: 10.3390/nano10020311 Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity Autori: Johannes G. Keller, Michael Persson, Philipp Müller, Lan Ma-Hock, Kai Werle, Josje Arts, Robert Landsiedel, Wendel Wohlleben Pubblicato in: NanoImpact, Issue 23, 2021, Page(s) 100341, ISSN 2452-0748 Editore: Elsevier B.V. DOI: 10.1016/j.impact.2021.100341 Chemical transformation and surface functionalisation affect the potential to group nanoparticles for risk assessment Autori: Carolin L. Schultz, Jessica Adams, Kerstin Jurkschat, Stephen Lofts, David J. Spurgeon Pubblicato in: Environmental Science: Nano, Issue 7/10, 2020, Page(s) 3100-3107, ISSN 2051-8153 Editore: Royal Society of Chemistry DOI: 10.1039/d0en00578a Organomodified nanoclays induce less inflammation, acute phase response, and genotoxicity than pristine nanoclays in mice lungs Autori: Emilio Di Ianni, Peter Møller, Alicja Mortensen, Józef Szarek, Per Axel Clausen, Anne Thoustrup Saber, Ulla Vogel, Nicklas Raun Jacobsen Pubblicato in: Nanotoxicology, Issue 14/7, 2020, Page(s) 869-892, ISSN 1743-5390 Editore: Informa Healthcare DOI: 10.1080/17435390.2020.1771786 Composites of epoxy and graphene-related materials: Nanostructure characterization and release quantification Autori: Tobias Hammer, Woranan Netkueakul, Peter Zolliker, Claudia Schreiner, Renato Figi, Oliver Braun, Jing Wang Pubblicato in: NanoImpact, Issue 20, 2020, Page(s) 100266, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2020.100266 Acute waterborne and chronic sediment toxicity of silver and titanium dioxide nanomaterials towards the oligochaete, Lumbriculus variegatus Autori: Simon Little, Helinor J. Johnston, Vicki Stone, Teresa F. Fernandes Pubblicato in: NanoImpact, Issue 21, 2021, Page(s) 100291, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2020.100291 A framework for grouping and read-across of nanomaterials- supporting innovation and risk assessment Autori: Vicki Stone, Stefania Gottardo, Eric A.J. Bleeker, Hedwig Braakhuis, Susan Dekkers, Teresa Fernandes, Andrea Haase, Neil Hunt, Danail Hristozov, Paula Jantunen, Nina Jeliazkova, Helinor Johnston, Lara Lamon, Fiona Murphy, Kirsten Rasmussen, Hubert Rauscher, Araceli Sánchez Jiménez, Claus Svendsen, David Spurgeon, Socorro Vázquez-Campos, Wendel Wohlleben, Agnes G. Oomen Pubblicato in: Nano Today, Issue 35, 2020, Page(s) 100941, ISSN 1748-0132 Editore: Elsevier BV DOI: 10.1016/j.nantod.2020.100941 A Method to Assess the Relevance of Nanomaterial Dissolution during Reactivity Testing Autori: Willie J. G. M. Peijnenburg, Emmanuel Ruggiero, Matthew Boyles, Fiona Murphy, Vicki Stone, Derek A. Elam, Kai Werle, Wendel Wohlleben Pubblicato in: Materials, Issue 13/10, 2020, Page(s) 2235, ISSN 1996-1944 Editore: MDPI Open Access Publishing DOI: 10.3390/ma13102235 A review to support the derivation of a worst-case dermal penetration value for nanoparticles Autori: Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer Pubblicato in: Regulatory Toxicology and Pharmacology, Issue 119, 2021, Page(s) 104836, ISSN 0273-2300 Editore: Academic Press DOI: 10.1016/j.yrtph.2020.104836 The effect of capping agents on the toxicity of silver nanoparticles to Danio rerio embryos Autori: N. Abramenko, T. B. Demidova, Yu. A. Krutyakov, P. M. Zherebin, E. Y. Krysanov, L. M. Kustov, W. Peijnenburg Pubblicato in: Nanotoxicology, Issue 13/1, 2018, Page(s) 1-13, ISSN 1743-5390 Editore: Informa Healthcare DOI: 10.1080/17435390.2018.1498931 Making use of available and emerging data to predict the hazards of engineered nanomaterials by means of in silico tools: A critical review Autori: G. Basei, D. Hristozov, L. Lamon, A. Zabeo, N. Jeliazkova, G. Tsiliki, A. Marcomini, A. Torsello Pubblicato in: NanoImpact, Issue 13, 2019, Page(s) 76-99, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2019.01.003 In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT Autori: Emilio Di Ianni, Johanna Samulin Erdem, Peter Møller, Nicklas Mønster Sahlgren, Sarah Søs Poulsen, Kristina Bram Knudsen, Shan Zienolddiny, Anne Thoustrup Saber, Håkan Wallin, Ulla Vogel, Nicklas Raun Jacobsen Pubblicato in: Particle and Fibre Toxicology, Issue 18/1, 2021, Page(s) Article number: 25 (2021), ISSN 1743-8977 Editore: BioMed Central DOI: 10.1186/s12989-021-00413-2 Importance of the number emission factor of combustion-generated aerosols from nano-enabled products Autori: Tobias Hammer, Nathan Bossa, Michael Persson, Adrian Wichser, Ken Lehner, Emmanuel Ruggiero, Ana Sofia Fonseca, Milijana Jovic, Sabyasachi Gaan, Wendel Wohlleben, Jing Wang Pubblicato in: NanoImpact, Issue 22, 2021, Page(s) 100307, ISSN 2452-0748 Editore: Elsevier B.V. DOI: 10.1016/j.impact.2021.100307 An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard Autori: Fiona Murphy, Susan Dekkers, Hedwig Braakhuis, Lan Ma-Hock, Helinor Johnston, Gemma Janer, Luisana di Cristo, Stefania Sabella, Nicklas Raun Jacobsen, Agnes G. Oomen, Andrea Haase, Teresa Fernandes, Vicki Stone Pubblicato in: NanoImpact, Issue 22, 2021, Page(s) 100314, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2021.100314 Source specific exposure and risk assessment for indoor aerosols Autori: Antti Joonas Koivisto, Kirsten Inga Kling, Otto Hänninen, Michael Jayjock, Jakob Löndahl, Aneta Wierzbicka, Ana Sofia Fonseca, Katrine Uhrbrand, Brandon E. Boor, Araceli Sánchez Jiménez, Kaarle Hämeri, Miikka Dal Maso, Susan F. Arnold, Keld A. Jensen, Mar Viana, Lidia Morawska, Tareq Hussein Pubblicato in: Science of The Total Environment, Issue 668, 2019, Page(s) 13-24, ISSN 0048-9697 Editore: Elsevier BV DOI: 10.1016/j.scitotenv.2019.02.398 Quality of physicochemical data on nanomaterials: an assessment of data completeness and variability Autori: Daniele Comandella, Stefania Gottardo, Iria Maria Rio-Echevarria, Hubert Rauscher Pubblicato in: Nanoscale, Issue 12/7, 2020, Page(s) 4695-4708, ISSN 2040-3364 Editore: Royal Society of Chemistry DOI: 10.1039/c9nr08323e Aerogels are not regulated as nanomaterials, but can be assessed by tiered testing and grouping strategies for nanomaterials Autori: Johannes G. Keller, Martin Wiemann, Sibylle Gröters, Kai Werle, Antje Vennemann, Robert Landsiedel, Wendel Wohlleben Pubblicato in: Nanoscale Advances, Issue 3/13, 2021, Page(s) 3881-3893, ISSN 2516-0230 Editore: Royal Society of Chemistry DOI: 10.1039/d1na00044f A Weight of Evidence approach to classify nanomaterials according to the EU Classification, Labelling and Packaging Regulation criteria Autori: Gianpietro Basei, Alex Zabeo, Kirsten Rasmussen, Georgia Tsiliki, Danail Hristozov Pubblicato in: NanoImpact, Issue 24, 2021, Page(s) 100359, ISSN 2452-0748 Editore: Elsevier B.V. DOI: 10.1016/j.impact.2021.100359 Pro-inflammatory response and genotoxicity caused by clay and graphene nanomaterials in A549 and THP-1 cells Autori: Emilio Di Ianni, Peter Møller, Ulla Birgitte Vogel, Nicklas Raun Jacobsen Pubblicato in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Issue 872, 2021, Page(s) 503405, ISSN 1383-5718 Editore: Elsevier BV DOI: 10.1016/j.mrgentox.2021.503405 Other (2) Guidance in a Nutshell: GRACIOUS Framework for grouping and read-across of nanomaterials and nanoforms Autori: Neil Hunt Pubblicato in: Issue 1, 2021 Editore: GRACIOUS DOI: 10.5281/zenodo.5534105 Guidance on the FRACIOUS Framework for grouping and read-across of nanomaterials and nanoforms Autori: Neil Hunt Pubblicato in: 2021 Editore: GRACIOUS DOI: 10.5281/zenodo.5534466 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
