BIOmaterial RIsk MAnagement

Risultati finali

The BIORIMA database fully populated will be reported and deliver to the EC

Environmental Exposure Assessment models, devices and scenarios including assessment/simulation of massive release of NBM

Report describing the modelling of the flows, the behaviour and the concentrations of NBM released into the environment.

Training Public Plan

Bionanonet will present the training plan in a public deliverable, as a tool to engage stakeholders

Strategies and methods for indoor/environmental and biological exposure monitoring and bio-marker based exposure assessment (bio-monitoring)

Report describing the strategies and methods for indoorenvironmental and biological exposure monitoring and biomarker based exposure assessment biomonitoring

Methods for assessing the release of NBM from implants into the body due to fracture/fatigue/tear

Report describing the release of NBM from implants into the body due to fracture/fatigue/tear.

Document containing all the validated characterization procedures and the data provided by the physicochemical characterization activity
IRM Framework implementation guidance document
Development ISO and CEN standards for implants

Report on the development of ISO and CEN standard for implants

Dissemination basics

WG will present the basic set of communication tools, including the website.

Dissemination basics

WG will present the basic set of communication tools, including the website.

Pubblicazioni

Toxicity and chemical transformation of silver nanoparticles in A549 lung cells: dose-rate-dependent genotoxic impact

Autori: Laure Bobyk; Adeline Tarantini; David Béal; Giulia Veronesi; Isabelle Kieffer; Sylvie Motellier; Eugenia Valsami-Jones; Iseult Lynch; Pierre-Henri Jouneau; Karin Pernet-Gallay; Catherine Aude-Garcia; Sylvie Sauvaigo; Thierry Douki; Thierry Rabilloud; Marie Carrière
Pubblicato in: Environmental Science: Nano, Numero 3, 2021, ISSN 2051-8161
Editore: Royal Society of Chemistry
DOI: 10.1039/d0en00533a

Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium.

Autori: Daniel Sanchez-Guzman; Sonja Boland; Oliver Brookes; Claire Mc Cord; René Lai Kuen; Valentina Sirri; Armelle Baeza Squiban; Stéphanie Devineau
Pubblicato in: Scientific Reports, Numero 11, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-86037-0

Nano-pesticides: the lunch-box principle—deadly goodies (semio-chemical functionalised nanoparticles that deliver pesticide only to target species)

Autori: J. J. Scott-Fordsmand; L. F. Fraceto; M. J. B. Amorim
Pubblicato in: Journal of Nanobiotechnology, Numero Vol 20, Iss 1, 2022, Pagina/e Pp 1-9 (2022), ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-021-01216-5

Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer.

Autori: Ida Kokalari; Sandeep Keshavan; Mizanur Rahman; Elena Gazzano; Giulia Barzan; Luisa Mandrile; Andrea Mario Giovannozzi; Jessica Ponti; Giulia Antonello; Marco P. Monopoli; Guido Perrone; Enrico Bergamaschi; Chiara Riganti; Bengt Fadeel; Ivana Fenoglio
Pubblicato in: Nanomedicine, Numero 16, 9, 2021, ISSN 1549-9642
Editore: Future Medicine
DOI: 10.2217/nnm-2021-0009

Applicability and Limitations in the Characterization of Poly-Dispersed Engineered Nanomaterials in Cell Media by Dynamic Light Scattering (DLS).

Autori: Marucco, Arianna; Aldieri, Elisabetta; Leinardi, Riccardo; Bergamaschi, Enrico; Riganti, Chiara; Fenoglio, Ivana
Pubblicato in: Materials, Numero Volume 12; Numero 23, 2019, Pagina/e Pages: 3833, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma12233833

Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics.

Autori: Maroua Ben Haddada; Dania Movia; Adriele Prina-Mello; Jolanda Spadavecchia
Pubblicato in: Colloids and Surfaces B: Biointerfaces, Numero 8, 2020, ISSN 1873-4367
Editore: Science Direct
DOI: 10.1016/j.colsurfb.2020.111172

Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products

Autori: Elisa Giubilato; Virginia Cazzagon; Mónica J.B. Amorim; Magda Blosi; Jacques Bouillard; Hans Bouwmeester; Anna Luisa Costa; Bengt Fadeel; Teresa F. Fernandes; Carlos Fito; Marina Hauser; Antonio Marcomini; Bernd Nowack; Lisa Pizzol; Leagh G. Powell; Adriele Prina-Mello; Haralambos Sarimveis; Janeck J. Scott-Fordsmand; Elena Semenzin; Burkhard Stahlmecke; Vicki Stone; Alexis Vignes; T A Wilkins; A
Pubblicato in: Materials, Numero 12 Numero 20, 2020, Pagina/e 4532, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma13204532

Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells

Autori: Di Cristo, Bianchi, Chiu, Taurino, Donato, Garzaro, Bussolati, Bergamaschi
Pubblicato in: Nanomaterials, Numero 9/7, 2019, Pagina/e 982, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano9070982

Meta-Analysis of Pharmacokinetic Studies of Nanobiomaterials for the Prediction of Excretion Depending on Particle Characteristics.

Autori: Marina Hauser; Bernd Nowack
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 3, 2019, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00405

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

Autori: Richard L. Marchese Robinson; Haralambos Sarimveis; Philip Doganis; Xiaodong Jia; Marianna Kotzabasaki; Christiana Gousiadou; Stacey L. Harper; T A Wilkins
Pubblicato in: Beilstein Journal of Nanotechnology, Numero 3, 2021, ISSN 2190-4286
Editore: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.12.97

Modelling local nanobiomaterial release and concentration hotspots in the environment.

Autori: Marina Hauser; Bernd Nowack
Pubblicato in: Environmental Pollution, Numero Volume 284, 2021, ISSN 1878-2450
Editore: Elsevier
DOI: 10.1016/j.envpol.2021.117399

Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape

Autori: Ali Kermanizadeh; Ali Kermanizadeh; Leagh G. Powell; Vicki Stone; Peter Møller
Pubblicato in: Kermanizadeh , A , Powell , L G , Stone , V & Møller , P 2018 , ' Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine : current landscape ' , International Journal of Nanomedicine , vol. 13 , pp. 7575-7605 . https://doi.org/10.2147/IJN.S177418, Numero 4, 2018, ISSN 1178-2013
Editore: Dove Press
DOI: 10.2147/ijn.s177418

Nano-bio interactions: a neutrophil-centric view.

Autori: Sandeep Keshavan; Paolo Calligari; Lorenzo Stella; Laura Fusco; Lucia Gemma Delogu; Bengt Fadeel
Pubblicato in: Nature, Numero 17, 2019, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-1806-8

Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105): using high-throughput gene expression in Enchytraeus crypticus.

Autori: Gomes, Susana I. L.; Roca, Carlos P.; von der Kammer, Frank; Scott-Fordsmand, Janeck J.; Amorim, Mónica J. B.
Pubblicato in: Gomes , S I L , Roca , C P , von der Kammer , F , Scott-Fordsmand , J J & Amorim , M J B 2018 , ' Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105) : using high-throughput gene expression in Enchytraeus crypticus ' , Nanoscale , vol. 10 , no. 46 , pp. 21960-21970 . https://doi.org/10.1039/c8nr03251c, Numero 1, 2018, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/c8nr03251c

Machine learning methods for multi-walled carbon nanotubes (MWCNT) genotoxicity prediction

Autori: Marianna Kotzabasaki; Iason Sotiropoulos; Costas A. Charitidis; Haralambos Sarimveis
Pubblicato in: Nanoscale Advances, Numero 11, 2021, ISSN 2516-0230
Editore: Royal Society of Chemistry
DOI: 10.1039/d0na00600a

Hide and Seek: Nanomaterial Interactions With the Immune System.

Autori: Bengt Fadeel
Pubblicato in: Frontiers in Immunology,, Numero Vol 10 (2019), 2019, ISSN 1664-3224
Editore: Lausanne Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.00133

Probabilistic modeling of nanobiomaterials release from medical applications into the environment

Autori: Hauser, Marina; Nowack, Bernd
Pubblicato in: zenodo, Numero 1, 2020, ISSN 2645-9132
Editore: CERN
DOI: 10.5281/zenodo.4040435

Pro- and anti-oxidant properties of near-infrared (NIR) light responsive carbon nanoparticles

Autori: Ida Kokalari, Riccardo Gassino, Andrea M. Giovannozzi, Luca Croin, Elena Gazzano, Enrico Bergamaschi, Andrea M. Rossi, Guido Perrone, Chiara Riganti, Jessica Ponti, Ivana Fenoglio
Pubblicato in: Free Radical Biology and Medicine, Numero 134, 2019, Pagina/e 165-176, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2019.01.013

Risk and life cycle assessment of nanoparticles for medical applications prepared using safe- and benign-by-design gas-phase syntheses

Autori: Weyell, P.; Kurland, H.-D.; Hülser, T.; Grabow, J.; Müller, F. A.; Kralisch, D.
Pubblicato in: Green Chemistry, Numero 1, 2020, ISSN 1757-7047
Editore: Royal Society of Chemistry
DOI: 10.1039/c9gc02436k

Graphene-Based Nanomaterials in Soil: Ecotoxicity Assessment Using Enchytraeus crypticus Reduced Full Life Cycle

Autori: Mendonça, Monique C. P.; Rodrigues, Natália P.; de Jesus, Marcelo B.; Amorim, Mónica J. B.
Pubblicato in: nanomaterials, Numero Numero 6, 17, 2019, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano9060858

Toxicokinetics of Ag (nano)materials in the soil model Enchytraeus crypticus (Oligochaeta) – impact of aging and concentration

Autori: Fátima C. F. Santos; Paula S. Tourinho; Janeck J. Scott-Fordsmand; Cornelis A.M. van Gestel; Mónica J.B. Amorim
Pubblicato in: Environmental Science: Nano, Numero 8(9), 2021, Pagina/e 2629 - 2640, ISSN 2051-8161
Editore: Royal Society of Chemistry
DOI: 10.1039/d1en00338k

Occupational risk of nano-biomaterials: Assessment of nano-enabled magnetite contrast agent using the BIORIMA Decision Support System

Autori: V. Cazzagon; E. Giubilato; L. Pizzol; C. Ravagli; S. Doumett; G. Baldi; M. Blosi; A. Brunelli; C. Fito; F. Huertas; A. Marcomini; E. Semenzin; A. Zabeo; I. Zanoni; D. Hristozov
Pubblicato in: NanoImpact, Numero Volume 25, 2021, ISSN 2452-0748
Editore: Elsevier
DOI: 10.1016/j.impact.2021.100373

Multiomics assessment in Enchytraeus crypticus exposed to Ag nanomaterials (Ag NM300K) and ions (AgNO3) – Metabolomics, proteomics (& transcriptomics)

Autori: V.L. Maria; David Licha; Janeck J. Scott-Fordsmand; Christian G. Huber; Mónica J.B. Amorim
Pubblicato in: Environmental Pollution, Numero vol. 286, 2021, Pagina/e 117571, ISSN 1878-2450
Editore: Science Direct
DOI: 10.1016/j.envpol.2021.117571

Evaluation of microbial shifts caused by a silver nanomaterial: comparison of four test systems

Autori: Kerstin Hund-Rinke, Anna Hümmler, Ruben Schlinkert, Franziska Wege, Gabriele Broll
Pubblicato in: Environmental Sciences Europe, Numero 31/1, 2019, ISSN 2190-4707
Editore: Springer Verlag
DOI: 10.1186/s12302-019-0268-z

Environmental hazard testing of nanobiomaterials

Autori: Mónica J.B. Amorim; M. L. Fernández-Cruz; Kerstin Hund-Rinke; Janeck J. Scott-Fordsmand
Pubblicato in: Environmental Sciences Europe, Numero 32, 2020, ISSN 2190-4715
Editore: Springer
DOI: 10.1186/s12302-020-00369-8

Machine learning and materials modelling interpretation of in vivo toxicological response to TiO2 nanoparticles library (UV and non-UV exposure).

Autori: Susana I. L. Gomes; Mónica J.B. Amorim; Suman Pokhrel; Suman Pokhrel; Lutz Mädler; Lutz Mädler; Matteo Fasano; Eliodoro Chiavazzo; Pietro Asinari; Jaak Jänes; Kaido Tämm; Jaanus Burk; Janeck J. Scott-Fordsmand
Pubblicato in: Nanoscale, Numero 35, 2021, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d1nr03231c

Multigenerational exposure of Folsomia candida to silver: Effect of different contamination scenarios (continuous versus pulsed and recovery)

Autori: Mendes, L.A.; Maria, V.L.; Scott-Fordsmand, J.J.; Amorim, M.J.B.
Pubblicato in: Science of the Total Environment, 2018, Pagina/e pp. 326-333, ISSN 1879-1026
Editore: Science Direct
DOI: 10.1016/j.scitotenv.2018.02.332

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Autori: Dania Movia, Maroua Benhaddada, Jolanda Spadavecchia, Adriele Prina-Mello
Pubblicato in: Precision Nanomedicine, 2020, ISSN 2639-9431
Editore: CLINAM
DOI: 10.33218/001c.12650

QSAR modeling of the toxicity classification of superparamagnetic iron oxide nanoparticles (SPIONs) in stem-cell monitoring applications: an integrated study from data curation to model development

Autori: Kotzabasaki, Marianna I.; Sotiropoulos, Iason; Sarimveis, Haralambos
Pubblicato in: RSC Advances, Numero 5, 2020, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ra09475j

Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors.

Autori: Sandeep Keshavan; Fernando Torres Andón; Fernando Torres Andón; Audrey Gallud; Audrey Gallud; Wei Chen; Knut Reinert; Lang Tran; Bengt Fadeel
Pubblicato in: Nanomaterials, Numero Vol 11, Iss 883, 2021, Pagina/e p 883, ISSN 2079-4991
Editore: Basel: MDPI AG
DOI: 10.3390/nano11040883

Pyrogenic and Precipitated Amorphous Silica Nanoparticles Differentially Affect Cell Responses to LPS in Human Macrophages.

Autori: Massimiliano G. Bianchi; Martina Chiu; Giuseppe Taurino; Roberta Ruotolo; Nelson Marmiroli; Enrico Bergamaschi; Francesco Cubadda; Ovidio Bussolati
Pubblicato in: Europe PMC, 2020
Editore: Embl-EBI
DOI: 10.3390/nano10071395

Additional file 1 of Environmental hazard testing of nanobiomaterials

Autori: Amorim, M. J. B.; M. L. Fernández-Cruz; K. Hund-Rinke; J. J. Scott-Fordsmand
Pubblicato in: Springer Nature, Numero 8, 2020
Editore: figshare
DOI: 10.6084/m9.figshare.12687151.v1

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autori: Andreas Falk; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Mar
Pubblicato in: Numero 5, 2022
Editore: ZENODO
DOI: 10.5281/zenodo.6818049

MOESM1 of Evaluation of microbial shifts caused by a silver nanomaterial: comparison of four test systems

Autori: Hund-Rinke, Kerstin; HĂźmmler, Anna; Schlinkert, Ruben; Wege, Franziska; Broll, Gabriele
Pubblicato in: Environmental Sciences Europe, 2019
Editore: Springer
DOI: 10.6084/m9.figshare.10264244

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Autori: Andreas Falk
Pubblicato in: Concept Paper, Numero 27, 2021
Editore: BIORIMA
DOI: 10.5281/zenodo.5004928

Nano-Biomaterial Risk Management

Autori: Tran, Lang; Janeck Scott-Fordsmand; Costa, Anna Luisa; Nowack, Bernd; Fadeel, Bengt; Hristozov, Danail; Fito-López, Carlos; Bregoli, Lisa; Reuther, Rudolf
Pubblicato in: Numero 5, 2021
Editore: BIORIMA
DOI: 10.5281/zenodo.4774948

Protein corona of NBMs

Autori: Monopoli, Marco; Moros, María
Pubblicato in: Numero 1, 2018
Editore: CSIC

Biodistribution of Nanoparticles in biological systems

Autori: Moros, María
Pubblicato in: Numero 4, 2018
Editore: Consejo Superior de Investigaciones Científicas (CSIC)

Risultati finali

Pubblicazioni

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