European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets

Información del proyecto

UbiCODE

Identificador del acuerdo de subvención: 765445

DOI

10.3030/765445

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 31 Diciembre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 407 194,44

Aportación de la UE

€ 3 407 194,44

Coordinado por

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Podcasts generated and launched
UbiCODE website launched and updated and presence in social media

Other (4)

Attainment of doctoral degrees
Supervisory Board

Supervisory Board settlement

Database for MS datasets

Database to hold large datasets from the MS analyses open to public

Database for screenings datasets

Documents, reports (2)

Outreach and research articles

Outreach and research article publications meetings events

Outreach and research article publications, meetings, events

Publicaciones

Book chapters (9)

SUMO-ID: A Strategy for the Identification of SUMO-Dependent Proximal Interactors

Autores: Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio & James D. Sutherland
Publicado en: 2022
Editor: Springer Protocols
DOI: 10.1007/978-1-0716-2859-1_13

Total Linear Chemical Synthesis of LC3A and LC3B

Autores: Yara Huppelschoten, Jens Buchardt, Thomas Eiland Nielsen & Gerbrand J. van der Heden van Noort
Publicado en: Methods in Molecular Biology, Edición 2602, 2022
Editor: Springer Protocols
DOI: 10.1007/978-1-0716-2859-1_4

Chemical Synthesis of Non-hydrolyzable Ubiquitin(-Like) Hybrid Chains

Autores: David A. Pérez Berrocal, Gerbrand J. van der Heden van Noort & Monique P. C. Mulder
Publicado en: Methods in Molecular Biology, Edición 2602, 2022
Editor: Springer Protocols
DOI: 10.1007/978-1-0716-2859-1_3

Isolation and Mass Spectrometry Identification of K48 and K63 Ubiquitin Proteome Using Chain-Specific Nanobodies

Autores: Maria Gonzalez-Santamarta, Laurie Ceccato, Ana Sofia Carvalho, Jean-Christophe Rain, Rune Matthiesen & Manuel S. Rodriguez
Publicado en: 2022
Editor: Springer Protocols
DOI: 10.1007/978-1-0716-2859-1_9

Biotin-based approaches for the study of SUMO and Ubiquitin modifications

Autores: Sutherland, JD; O, Barroso-Gomila; Barrio, R
Publicado en: Edición 3, 2019
Editor: Caister Academic Press
DOI: 10.5281/zenodo.3601585

Biochemical characterization of SUMO-conjugating enzymes by in vitro sumoylation assays

Autores: Nathalie Eisenhardt, Dragana Ilic, Easa Nagamalleswari, Andrea Pichler
Publicado en: Ubiquitin and Ubiquitin-like Protein Modifiers, Edición 618, 2019, Página(s) 167-185, ISBN 9780-128163597
Editor: Elsevier
DOI: 10.1016/bs.mie.2018.12.025

Biotin-based Approaches for the Study of Ubiquitin and Ubiquitin-like Protein Modifications

Autores: James D. Sutherland, Orhi Barroso Gomila, Rosa Barrio
Publicado en: SUMOylation and Ubiquitination: Current and Emerging Concepts, 2019, ISBN 9781-912530120
Editor: Caister Academic Press
DOI: 10.21775/9781912530120.07

Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma

Autores: Maria Gonzalez-Santamarta, Grégoire Quinet, Diana Reyes-Garau, Brigitte Sola, Gaël Roué, Manuel S. Rodriguez
Publicado en: Proteostasis and Disease - From Basic Mechanisms to Clinics, Edición 1233, 2020, Página(s) 153-174, ISBN 978-3-030-38265-0
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-38266-7_6

Role of Sumoylation in Neurodegenerative Diseases and Inflammation

Autores: Esmeralda Parra-Peralbo, Veronica Muratore, Orhi Barroso-Gomila, Ana Talamillo, James D. Sutherland, Rosa Barrio
Publicado en: 2021
Editor: CRC Press
DOI: 10.1201/9781003048138-08

Peer reviewed articles (18)

Structural mechanism of cGAS inhibition by the nucleosome

Autores: Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
Publicado en: Nature, Edición 587/7835, 2020, Página(s) 668-672, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

Identification of proximal SUMO-dependent interactors using SUMO-ID

Autores: Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland
Publicado en: Nature Communications, Edición 12, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26807-6

The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

Autores: Tom Cremer, Marlieke L.M. Jongsma, Fredrik Trulsson, Alfred C.O. Vertegaal, Jacques Neefjes, Ilana Berlin
Publicado en: Cell Reports, Edición 34/3, 2021, Página(s) 108659, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108659

Rational discovery of molecular glue degraders via scalable chemical profiling

Autores: Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H. Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C. Müller, Johannes Zuber, Matthias Geyer, Nicolas H. Thomä, Stefan Kubicek, Georg E. Winter
Publicado en: Nature Chemical Biology, Edición 16/11, 2020, Página(s) 1199-1207, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-0594-x

The role of SUMOylation during development

Autores: Ana Talamillo, Orhi Barroso-Gomila, Immacolata Giordano, Leiore Ajuria, Marco Grillo, Ugo Mayor, Rosa Barrio
Publicado en: Biochemical Society Transactions, Edición 48/2, 2020, Página(s) 463-478, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20190390

Haven't got a glue: Protein surface variation for the design of molecular glue degraders

Autores: Zuzanna Kozicka, Nicolas Holger Thomä
Publicado en: Cell Chemical Biology, 2021, ISSN 2451-9456
Editor: Cell Press
DOI: 10.1016/j.chembiol.2021.04.009

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

Autores: Fredrik Trulsson; Vyacheslav Akimov; Mihaela Robu; Nila van Overbeek; David Aureliano Pérez Berrocal; Rashmi G. Shah; Jürgen Cox; Girish M. Shah; Blagoy Blagoev; Alfred C. O. Vertegaal
Publicado en: Nature Communication, Edición 13, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30376-7

SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes

Autores: Immacolata Giordano, Lucia Pirone, Veronica Muratore, Eukene Landaluze, Coralia Pérez, Valerie Lang, Elisa Garde-Lapido, Monika Gonzalez-Lopez, Orhi Barroso-Gomila, Alfred C O Vertegaal, Ana M Aransay, Jose Antonio Rodriguez, Manuel S Rodriguez, James D Sutherland, Rosa Barrio
Publicado en: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2021.715868

Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code

Autores: David A. Pérez Berrocal, Katharina F. Witting, Huib Ovaa, Monique P. C. Mulder
Publicado en: Frontiers in Chemistry, Edición 7, 2020, ISSN 2296-2646
Editor: Frontiers in biochemistry
DOI: 10.3389/fchem.2019.00931

Taking the Brakes Off Targeted Protein Degradation

Autores: Zuzanna Kozicka, Georg Petzold, Nicolas H. Thomä
Publicado en: Cell Chemical Biology, Edición 27/1, 2020, Página(s) 16-18, ISSN 2451-9456
Editor: Cell Press
DOI: 10.1016/j.chembiol.2019.12.010

Mechanisms of OCT4-SOX2 motif readout on nucleosomes

Autores: Alicia K. Michael, Ralph S. Grand, Luke Isbel, Simone Cavadini, Zuzanna Kozicka, Georg Kempf, Richard D. Bunker, Andreas D. Schenk, Alexandra Graff-Meyer, Ganesh R. Pathare, Joscha Weiss, Syota Matsumoto, Lukas Burger, Dirk Schübeler, Nicolas H. Thomä
Publicado en: Science, 2020, Página(s) eabb0074, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abb0074

Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy

Autores: Grégoire Quinet, Maria Gonzalez-Santamarta, Clara Louche, Manuel S. Rodriguez
Publicado en: Molecules, Edición 25/10, 2020, Página(s) 2352, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25102352

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Autores: Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard D. Bunker, Katherine A. Donovan, Quinlan L. Sievers, Jonas Koeppel, Dakota Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä, Benjamin L. E
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2374-x

SUMOylation in the control of cholesterol homeostasis

Autores: Ana Talamillo, Leiore Ajuria, Marco Grillo, Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio
Publicado en: Open Biology, Edición 10/5, 2020, Página(s) 200054, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1098/rsob.200054

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

Autores: Laura Bozal-Basterra, María Gonzalez-Santamarta, Veronica Muratore, Aitor Bermejo-Arteagabeitia, Carolina Da Fonseca, Orhi Barroso-Gomila, Mikel Azkargorta, Ibon Iloro, Olatz Pampliega, Ricardo Andrade, Natalia Martín-Martín, Tess C Branon, Alice Y Ting, Jose A Rodríguez, Arkaitz Carracedo, Felix Elortza, James D Sutherland, Rosa Barrio
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.55957

Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection

Autores: Robbert Q. Kim, Mohit Misra, Alexis Gonzalez, Ines Tomašković, Donghyuk Shin, Hermann Schindelin, Dmitri V. Filippov, Huib Ovaa, Ivan Đikić, Gerbrand J. Heden van Noort
Publicado en: Chemistry – A European Journal, Edición 27/7, 2021, Página(s) 2506-2512, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004590

Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia

Autores: Rosa G. Lopez‐Reyes, Grégoire Quinet, Maria Gonzalez‐Santamarta, Clément Larrue, Jean‐Emmanuel Sarry, Manuel S. Rodriguez
Publicado en: FEBS Open Bio, Edición 11/1, 2021, Página(s) 48-60, ISSN 2211-5463
Editor: Elsevier BV
DOI: 10.1002/2211-5463.12950

Identification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells

Autores: Barbara Mojsa; Michael H. Tatham; Lindsay Davidson; Magda Liczmanska; Emma Branigan; Ronald T. Hay
Publicado en: Molecular and Cellular Proteomics, Edición 1, 2021, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100164

Non-peer reviewed articles (9)

Studying the ubiquitin code through biotin-based labelling methods

Autores: Orhi Barroso-Gomila, Veronica Muratore, Laura Merino-Cacho, Jose Antonio Rodriguez, Rosa Barrio, James D. Sutherland
Publicado en: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.02.009

Fast friends – Ubiquitin-like modifiers as engineered fusion partners

Autores: Evrydiki Asimaki, Kirill Petriukov, Christian Renz, Cindy Meister, Helle D.Ulrich
Publicado en: Seminars in Cell & Developmental Biology, 2021, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.11.013

Site-specific proteomic strategies to identify ubiquitin and SUMO modifications: Challenges and opportunities

Autores: Fredrik Trulsson, Alfred C. O. Vertegaal
Publicado en: Seminars in Cell and Developmental Biology, 2021, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.11.006

Membrane compartmentalisation of the ubiquitin system

Autores: Emma V. Rusilowicz-Jones; Ailbhe J. Brazel; Francesca Frigenti; Sylvie Urbé; Michael J. Clague
Publicado en: Seminars in Cell & Developmental Biology, 2021, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.11.016

Ubiquitin-chains dynamics and its role regulating crucial cellular processes

Autores: Maria Gonzalez-Santamarta, Corentin Bouvier, Manuel S. Rodriguez and Wendy Xolalpa
Publicado en: Seminars in Cell & Developmental Biology, 2021, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.11.023

Chemical biology tools to study Deubiquitinases and Ubl proteases

Autores: Magdalena Gorka; Helge Magnus Magnussen; Yogesh Kulathu
Publicado en: Seminars in Cell & Developmental Biology, Edición 1, 2022, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.02.006

State of the art in (semi-)synthesis of Ubiquitin- and Ubiquitin-like tools

Autores: Yara Huppelschoten, Gerbrand J.van der Heden van Noort
Publicado en: Seminars in Cell & Developmental Biology, 2021, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.11.025

Ubiquitin and Legionella: From bench to bedside

Autores: Ines Tomaskovic; Alexis Gonzalez; Ivan Dikic
Publicado en: Seminars in Cell & Developmental Biology, Edición 1, 2022, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.02.008

Stress - Regulation of SUMO conjugation and of other Ubiquitin‐Like Modifiers

Autores: Dragana Ilic, Helge M. Magnussen, Marilyn Tirard
Publicado en: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2021.12.010

Other (2)

SUMO maintains the chromatin environment of human induced pluripotent stem cells

Autores: Barbara Mojsa; Michael H. Tatham; Lindsay Davidson; Magda Liczmanska; Jane E. Wright; Nicola Wiechens; Marek Gierlinski; Tom Owen-Hughes; Ronald T. Hay
Publicado en: bioRxiv, 2021
Editor: bioRxiv
DOI: 10.1101/2020.12.22.423944

Identification of proximal SUMO-dependent interactors using SUMO-ID

Autores: Orhi Barroso-Gomila; Fredrik Trulsson; Veronica Muratore; Iñigo Canosa; Ana Rosa Cortazar; Coralia Perez; Mikel Azkargorta; Ibon Iloro; Arkaitz Carracedo; Ana M Aransay; Felix Elortza; Ugo Mayor; Alfred C. O. Vertegaal; Rosa Barrio; James D. Sutherland
Publicado en: bioRxiv, Edición 1, 2020
Editor: bioRxiv
DOI: 10.1101/2020.12.28.424528