Selective Agonists For Serotonin Receptors

Projektinformationen

SAFER

ID Finanzhilfevereinbarung: 765657

DOI

10.3030/765657

Projekt abgeschlossen

EK-Unterschriftsdatum 3 August 2017

Startdatum 1 September 2017

Enddatum 31 August 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 1 286 630,94

EU-Beitrag

€ 1 286 630,94

Koordiniert durch

KOBENHAVNS UNIVERSITET
Denmark

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (8)

Functionally selective ligand scaffolds from virtual screening

Virtual screening for new 5HT2A ligand scaffolds with functional selectivity

Holistic signalling pathway profiles of new 5-HT2A ligands

Evaluate the receptor subtype and signalling pathwayprofiles of new inhouse lead ligands from synthesis T23 and VS T24

2nd report on dissemination activities

Report on dissemination/outreach activities

3rd report on dissemination activities

Report on dissemination/outreach activities

Functionally selective ligands from in-house synthesis

Synthesise putatively modelbased selective ligands

Model of structural mechanisms for 5-HT2A biased agonism

Build 3D molecular models for rationalisation and design of functionally selective 5HT2A ligands

1st report on dissemination activities

Report on dissemination/outreach activities

4th report on dissemination activities

Report on dissemination/outreach activities

Websites, patent fillings, videos etc. (2)

Ligand database incl. biased agonism – public version in GPCRdb

Provide data design specifications and inhouse pilot data

SAFER web site

SAFER website implementation.

Veröffentlichungen

Peer reviewed articles (2)

GPCRdb in 2021: integrating GPCR sequence, structure and function

Autoren: Albert J Kooistra, Stefan Mordalski, Gáspár Pándy-Szekeres, Mauricio Esguerra, Alibek Mamyrbekov, Christian Munk, György M Keserű, David E Gloriam
Veröffentlicht in: Nucleic Acids Research, Ausgabe 49/D1, 2020, Seite(n) D335-D343, ISSN 0305-1048
Herausgeber: Oxford University Press
DOI: 10.1093/nar/gkaa1080

Structural insights into the lipid and ligand regulation of serotonin receptors

Autoren: Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X. Edward Zhou, Xi Cheng, Icaro A. Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V. Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E. Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H. Eric Xu
Veröffentlicht in: Nature, Ausgabe 592/7854, 2021, Seite(n) 469-473, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-021-03376-8