Selective Agonists For Serotonin Receptors

Informazioni relative al progetto

SAFER

ID dell’accordo di sovvenzione: 765657

DOI

10.3030/765657

Progetto chiuso

Data della firma CE 3 Agosto 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 1 286 630,94

Contributo UE

€ 1 286 630,94

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (8)

Functionally selective ligand scaffolds from virtual screening

Virtual screening for new 5HT2A ligand scaffolds with functional selectivity

Holistic signalling pathway profiles of new 5-HT2A ligands

Evaluate the receptor subtype and signalling pathwayprofiles of new inhouse lead ligands from synthesis T23 and VS T24

2nd report on dissemination activities

Report on dissemination/outreach activities

3rd report on dissemination activities

Report on dissemination/outreach activities

Functionally selective ligands from in-house synthesis

Synthesise putatively modelbased selective ligands

Model of structural mechanisms for 5-HT2A biased agonism

Build 3D molecular models for rationalisation and design of functionally selective 5HT2A ligands

1st report on dissemination activities

Report on dissemination/outreach activities

4th report on dissemination activities

Report on dissemination/outreach activities

Websites, patent fillings, videos etc. (2)

Ligand database incl. biased agonism – public version in GPCRdb

Provide data design specifications and inhouse pilot data

SAFER web site

SAFER website implementation.

Pubblicazioni

Peer reviewed articles (2)

GPCRdb in 2021: integrating GPCR sequence, structure and function

Autori: Albert J Kooistra, Stefan Mordalski, Gáspár Pándy-Szekeres, Mauricio Esguerra, Alibek Mamyrbekov, Christian Munk, György M Keserű, David E Gloriam
Pubblicato in: Nucleic Acids Research, Numero 49/D1, 2020, Pagina/e D335-D343, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1080

Structural insights into the lipid and ligand regulation of serotonin receptors

Autori: Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X. Edward Zhou, Xi Cheng, Icaro A. Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V. Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E. Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H. Eric Xu
Pubblicato in: Nature, Numero 592/7854, 2021, Pagina/e 469-473, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03376-8