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ACOUSTIC MARKERS FOR ENHANCED REMOTE SENSING OF RADIATION DOSES

Ziel

Approximately 50% of all cancer patients receive radiation therapy as part of their treatment. The aim is hereby to maximise tumor irradiation and to minimize healthy tissue irradiation. This implies a need for appropriate dosimetry strategies that can effectively measure the actual radiation dose imparted on the tumor. However, state-of-the-art dosimetry cannot quantify the dose distribution in (and around) the tumor, hereby inhibiting the full potential of radiotherapy.
AMFORA aims to develop a non-invasive in-situ dosimetry system for radiation therapy with the potential of on-line dose assessment by casting ultrasound contrast agents (UCAs) into dose sensing theranostic devices. UCAs will be upgraded to injectable dose-sensitive and targeted devices that gather in tumor tissue and translate imparted radiation dosage into a
modulation of their acoustic response upon ultrasound interrogation. Tailored ultrasound imaging and advanced signal processing algorithms will be developed to extract the (change in) acoustic signature of UCAs from backscatter data and to translate this information into a 2D or 3D dose distribution map. The specific objectives of this project are the design, development and pre-clinical validation of the aforementioned UCA based dosimetry system and a customised ultrasound
read-out technology. Upon successful completion, AMFORA will have enabled the assessment of the effective radiation dose distribution in (and around) the tumor, offering an advanced and objective means to compare and evaluate treatment efficacy of different radiotherapy modalities. Such novel technology would revolutionize quality assurance and treatment follow up in radiotherapy, which also unmistakably will lead to increased patient safety and improved treatment protocols. Moreover, AMFORA is expected to trigger an avalanche of novel technologies for radiation therapy delivery and to pave the way for other in-vivo UCA based distributed sensing applications.

Aufforderung zur Vorschlagseinreichung

H2020-FETOPEN-2016-2017

Andere Projekte für diesen Aufruf anzeigen

Unterauftrag

H2020-FETOPEN-1-2016-2017

Koordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Netto-EU-Beitrag
€ 1 563 750,00
Adresse
Oude Markt 13
3000 Leuven
Belgien

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Aktivitätstyp
Higher or Secondary Education Establishments
Weitere Finanzmittel
€ 0,00

Beteiligte (5)

DOSEVUE
Belgien
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€ 376 875,00
Adresse
Agoralaan A Bis
3590 Diepenbeek

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KMU

Die Organisation definierte sich zum Zeitpunkt der Unterzeichnung der Finanzhilfevereinbarung selbst als KMU (Kleine und mittlere Unternehmen).

Ja
Region
Vlaams Gewest Prov. Limburg (BE) Arr. Hasselt
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Weitere Finanzmittel
€ 0,00
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italien
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€ 475 000,00
Adresse
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Aktivitätstyp
Higher or Secondary Education Establishments
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€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Deutschland
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€ 679 878,75
Adresse
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Aktivitätstyp
Research Organisations
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€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Niederlande
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€ 443 750,00
Adresse
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Aktivitätstyp
Higher or Secondary Education Establishments
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€ 0,00
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgien
Netto-EU-Beitrag
€ 393 521,25
Adresse
Kapeldreef 75
3001 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Aktivitätstyp
Research Organisations
Weitere Finanzmittel
€ 0,00