Skip to main content



Project Closing Event

Project closing event

Targeted UCA batches, with in-vitro evaluation of targeting efficacy

Availability of targeted UCA batches with invitro evaluationof targeting efficacy

Project Opening Event

Project opening event

Optimized Targeted Dosimetric UCAs

UCAs that are accumulating in and around tumour tissue

Data Management Plan

final data management plan

Dissemination and Exploitation Plan

Final Dissemination and Exploitation Plan

Updated Dissemination and Exploitation Plan (2nd major update)

Updated Dissemination and Exploitation Plan 2nd and final major update

Shortlist of Dosimetric UCAs

Report regarding UCA formulations and PCF & acoustic characterization, and in-vitro biological studies. Definition of UCA design priorities, based on dose-sensitivity, robustness of acoustic response w.r.t. measurement conditions and bio-compatibility.

Intermediate report on backscatter modeling

Intermediate report on the backscatter model and its validation

In Vitro POC: Homogeneous Dilutions

First Ultrasound approach for dose read out. Approach demonstrated in homogeneous UCA dilutions.


Rectangular 1014 element matrix array for transperineal imaging

Autoren: D. Speicher, H. Hewener, S. Therre, S. Tretbar and M. Fournelle,
Veröffentlicht in: IEEE IUS 2021, 2021, Page(s) 1-4, ISBN 978-1-6654-0355-9
Herausgeber: IEEE
DOI: 10.1109/ius52206.2021.9593385

Development and characterization of a sparse ellipsoidal 256 element array for volumetric ultrasound imaging

Autoren: M. Fournelle et al.
Veröffentlicht in: IEEE International Ultrasonics Symposium (IUS), 2021, Page(s) 1-3, ISBN 978-1-6654-4777-5
Herausgeber: IEEE
DOI: 10.1109/ius52206.2021.9593506

Real-Time Volumetric Ultrasound Research Platform with 1024 Parallel Transmit and Receive Channels

Autoren: Christoph Risser; Holger Hewener; Marc Fournelle; Heinrich Fonfara; Selina Barry-Hummel; Steffen Weber; Daniel Speicher; Steffen Tretbar
Veröffentlicht in: Volume 11, 4, 2021, ISSN 2076-3417
Herausgeber: Applied Sciences
DOI: 10.3390/app11135795

Effect of a Radiotherapeutic Megavoltage Beam on Ultrasound Contrast Agents

Autoren: Collado-Lara, G., Heymans, S.V., Godart, J., D’Agostino, E., D’hooge, J., Van Den Abeele, K., Vos, H.J., de Jong, N.,
Veröffentlicht in: Ultrasound in Medicine & Biology, 2021, ISSN 0301-5629
Herausgeber: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.02.021

Deep learning for dose assessment in radiotherapy by the super-localization of vaporized nanodroplets in high frame rate ultrasound imaging

Autoren: Brent van der Heyden, Sophie Heymans, Bram Carlier, Gonzalo Collado-Lara, Edmond Sterpin and Jan D'hooge
Veröffentlicht in: Physics in Medicine & Biology, 00319155, 2022, Page(s) 5015, ISSN 0031-9155
Herausgeber: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac6cc3

Acoustic Modulation Enables Proton Detection with Nanodroplets at Body Temperature

Autoren: Heymans, S.V., Collado-Lara, G., Rovituso, M., Vos, H.J., D’hooge, J., De Jong, N., Van Den Abeele, K.,
Veröffentlicht in: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2022, ISSN 0885-3010
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2022.3164805

Spatially Variant Ultrasound Attenuation Mapping Using a Regularized Linear Least-Squares Approach

Autoren: Jasleen Birdi; Jan D'hooge; Alexander Bertrand
Veröffentlicht in: Crossref, 4, 2022, Page(s) 1596 - 1609, ISSN 0885-3010
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2022.3157949

Fast linear least-squares method for ultrasound attenuation and backscatter estimation

Autoren: Jasleen Birdi; Arun Muraleedharan; Jan D'hooge; Alexander Bertrand
Veröffentlicht in: Ultrasonics, 1, 2021, ISSN 0041-624X
Herausgeber: Elsevier BV
DOI: 10.1016/j.ultras.2021.106503

Modulating ultrasound contrast generation from injectable nanodroplets for proton range verification by varying the degree of superheat.

Autoren: Sophie V. Heymans; Bram Carlier; Yosra Toumia; Sjoerd Nooijens; Marcus Ingram; Andrea Giammanco; Emiliano D'Agostino; Wouter Crijns; Alexander Bertrand; Gaio Paradossi; Uwe Himmelreich; Jan D'hooge; Edmond Sterpin; Koen Van Den Abeele
Veröffentlicht in: Medical Physics, (2021), 1, 2021, ISSN 0094-2405
Herausgeber: American Association of Physicists in Medicine
DOI: 10.1002/mp.14778

Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study

Autoren: Yosra Toumia,corresponding author1,2 Marco Pullia,3 Fabio Domenici,1,2 Angelica Facoetti,3 Michele Ferrarini,3 Sophie V. Heymans,4,5,6 Bram Carlier,7 Koen Van Den Abeele,4 Edmond Sterpin,7 Jan D’hooge,5 Emiliano D’Agostino,8 and Gaio Paradossi1,2
Veröffentlicht in: Scientific reports, 2022, Page(s) 12(1), 8012, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-022-11524-x

Utility Metrics for Assessment and Subset Selection of Input Variables for Linear Estimation [Tips & Tricks]

Autoren: Alexander Bertrand
Veröffentlicht in: IEEE Signal Processing Magazine, 35/6, 2018, Page(s) 93-99, ISSN 1053-5888
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.1109/MSP.2018.2856632

Dynamics of the phospholipid shell of microbubbles: a fluorescence photoselection and spectral phasor approach

Autoren: Eli Slenders, Senne Seneca, Sumit Kumar Pramanik, Nick Smisdom, Peter Adriaensens, Martin vandeVen, Anitha Ethirajan, Marcel Ameloot
Veröffentlicht in: Chemical Communications, 54/38, 2018, Page(s) 4854-4857, ISSN 1359-7345
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/c8cc01012a

Proton range verification with ultrasound imaging using injectable radiation sensitive nanodroplets: a feasibility study.

Autoren: Bram Carlier; Sophie V. Heymans; Sjoerd Nooijens; Yosra Toumia; Marcus Ingram; Gaio Paradossi; Emiliano D'Agostino; Uwe Himmelreich; Jan D'hooge; Koen Van Den Abeele; Edmond Sterpin
Veröffentlicht in: Physics in Medicine and Biology, Vol. 65, no.6, p. 17 (2020), 6, 2020, ISSN 1361-6560
Herausgeber: -
DOI: 10.1088/1361-6560/ab7506

Ultrasound-assisted investigation of photon triggered vaporization of poly(vinylalcohol) phase-change nanodroplets: A preliminary concept study with dosimetry perspective

Autoren: Yosra Toumia; Roberto Miceli; Fabio Domenici; Sophie V. Heymans; Bram Carlier; Madalina Cociorb; Letizia Oddo; Piero Rossi; Rolando Maria D'Angellilo; Edmond Sterpin; Emiliano D'Agostino; Koen Van Den Abeele; Jan D'hooge; Gaio Paradossi
Veröffentlicht in: Physica Medica, Vol. 89, p. 232-242 (2021), 3, 2021, ISSN 1120-1797
Herausgeber: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.08.006

Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification

Autoren: Gonzalo Collado-Lara; Sophie V. Heymans; Sophie V. Heymans; Marta Rovituso; Bram Carlier; Yosra Toumia; Martin D. Verweij; Martin D. Verweij; Gaio Paradossi; Edmond Sterpin; Hendrik J. Vos; Hendrik J. Vos; Jan D'hooge; Nico de Jong; Nico de Jong; Koen Van Den Abeele; Verya Daeichin
Veröffentlicht in: VOLUME=48;ISSUE=1;ISSN=0301-5629;TITLE=Ultrasound in Medicine & Biology, 3, 2022, ISSN 0301-5629
Herausgeber: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.09.009

Phase Change Ultrasound Contrast Agents with a Photopolymerized Diacetylene Shell

Autoren: Toumia, Y.; Cerroni, B.; Domenici, F.; Lange, H.; Bianchi, L.; Cociorb, M.; Brasili, F.; Chiessi, E.; D' Agostino, E.; Van Den Abeele, K.; Heymans, S. V.; D' Hooge, J.; Paradossi, G.
Veröffentlicht in: Langmuir, 5, 2019, ISSN 0743-7463
Herausgeber: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01160