ACOUSTIC MARKERS FOR ENHANCED REMOTE SENSING OF RADIATION DOSES

Deliverables

Other (3)

Project Closing Event

Project closing event

Targeted UCA batches, with in-vitro evaluation of targeting efficacy

Availability of targeted UCA batches with invitro evaluationof targeting efficacy

Project Opening Event

Project opening event

Open Research Data Pilot (5)

Optimized Targeted Dosimetric UCAs

UCAs that are accumulating in and around tumour tissue

Data Management Plan

final data management plan

Dissemination and Exploitation Plan

Final Dissemination and Exploitation Plan

Updated Dissemination and Exploitation Plan (1st major update)

Updated Dissemination and Exploitation Plan (2nd major update)

Updated Dissemination and Exploitation Plan 2nd and final major update

Documents, reports (5)

review meeting documents meeting 2

review meeting documents meeting 3

Shortlist of Dosimetric UCAs

Report regarding UCA formulations and PCF & acoustic characterization, and in-vitro biological studies. Definition of UCA design priorities, based on dose-sensitivity, robustness of acoustic response w.r.t. measurement conditions and bio-compatibility.

review meeting documents meeting 1

Intermediate report on backscatter modeling

Intermediate report on the backscatter model and its validation

Demonstrators, pilots, prototypes (1)

In Vitro POC: Homogeneous Dilutions

First Ultrasound approach for dose read out. Approach demonstrated in homogeneous UCA dilutions.

Websites, patent fillings, videos etc. (1)

Website & project logo

website and project logo of AMFORA

Publications

Conference proceedings (2)

Rectangular 1014 element matrix array for transperineal imaging

Author(s): D. Speicher, H. Hewener, S. Therre, S. Tretbar and M. Fournelle,
Published in: IEEE IUS 2021, 2021, Page(s) 1-4, ISBN 978-1-6654-0355-9
Publisher: IEEE
DOI: 10.1109/ius52206.2021.9593385

Development and characterization of a sparse ellipsoidal 256 element array for volumetric ultrasound imaging

Author(s): M. Fournelle et al.
Published in: IEEE International Ultrasonics Symposium (IUS), 2021, Page(s) 1-3, ISBN 978-1-6654-4777-5
Publisher: IEEE
DOI: 10.1109/ius52206.2021.9593506

Peer reviewed articles (14)

Real-Time Volumetric Ultrasound Research Platform with 1024 Parallel Transmit and Receive Channels

Author(s): Christoph Risser; Holger Hewener; Marc Fournelle; Heinrich Fonfara; Selina Barry-Hummel; Steffen Weber; Daniel Speicher; Steffen Tretbar
Published in: Volume 11, 4, 2021, ISSN 2076-3417
Publisher: Applied Sciences
DOI: 10.3390/app11135795

Effect of a Radiotherapeutic Megavoltage Beam on Ultrasound Contrast Agents

Author(s): Collado-Lara, G., Heymans, S.V., Godart, J., D’Agostino, E., D’hooge, J., Van Den Abeele, K., Vos, H.J., de Jong, N.,
Published in: Ultrasound in Medicine & Biology, 2021, ISSN 0301-5629
Publisher: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.02.021

Deep learning for dose assessment in radiotherapy by the super-localization of vaporized nanodroplets in high frame rate ultrasound imaging

Author(s): Brent van der Heyden, Sophie Heymans, Bram Carlier, Gonzalo Collado-Lara, Edmond Sterpin and Jan D'hooge
Published in: Physics in Medicine & Biology, 00319155, 2022, Page(s) 5015, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac6cc3

Acoustic Modulation Enables Proton Detection with Nanodroplets at Body Temperature

Author(s): Heymans, S.V., Collado-Lara, G., Rovituso, M., Vos, H.J., D’hooge, J., De Jong, N., Van Den Abeele, K.,
Published in: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2022, ISSN 0885-3010
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2022.3164805

Spatially Variant Ultrasound Attenuation Mapping Using a Regularized Linear Least-Squares Approach

Author(s): Jasleen Birdi; Jan D'hooge; Alexander Bertrand
Published in: Crossref, 4, 2022, Page(s) 1596 - 1609, ISSN 0885-3010
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2022.3157949

Fast linear least-squares method for ultrasound attenuation and backscatter estimation

Author(s): Jasleen Birdi; Arun Muraleedharan; Jan D'hooge; Alexander Bertrand
Published in: Ultrasonics, 1, 2021, ISSN 0041-624X
Publisher: Elsevier BV
DOI: 10.1016/j.ultras.2021.106503

Modulating ultrasound contrast generation from injectable nanodroplets for proton range verification by varying the degree of superheat.

Author(s): Sophie V. Heymans; Bram Carlier; Yosra Toumia; Sjoerd Nooijens; Marcus Ingram; Andrea Giammanco; Emiliano D'Agostino; Wouter Crijns; Alexander Bertrand; Gaio Paradossi; Uwe Himmelreich; Jan D'hooge; Edmond Sterpin; Koen Van Den Abeele
Published in: Medical Physics, (2021), 1, 2021, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.14778

Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study

Author(s): Yosra Toumia,corresponding author1,2 Marco Pullia,3 Fabio Domenici,1,2 Angelica Facoetti,3 Michele Ferrarini,3 Sophie V. Heymans,4,5,6 Bram Carlier,7 Koen Van Den Abeele,4 Edmond Sterpin,7 Jan D’hooge,5 Emiliano D’Agostino,8 and Gaio Paradossi1,2
Published in: Scientific reports, 2022, Page(s) 12(1), 8012, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-11524-x

Utility Metrics for Assessment and Subset Selection of Input Variables for Linear Estimation [Tips & Tricks]

Author(s): Alexander Bertrand
Published in: IEEE Signal Processing Magazine, 35/6, 2018, Page(s) 93-99, ISSN 1053-5888
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/MSP.2018.2856632

Dynamics of the phospholipid shell of microbubbles: a fluorescence photoselection and spectral phasor approach

Author(s): Eli Slenders, Senne Seneca, Sumit Kumar Pramanik, Nick Smisdom, Peter Adriaensens, Martin vandeVen, Anitha Ethirajan, Marcel Ameloot
Published in: Chemical Communications, 54/38, 2018, Page(s) 4854-4857, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc01012a

Proton range verification with ultrasound imaging using injectable radiation sensitive nanodroplets: a feasibility study.

Author(s): Bram Carlier; Sophie V. Heymans; Sjoerd Nooijens; Yosra Toumia; Marcus Ingram; Gaio Paradossi; Emiliano D'Agostino; Uwe Himmelreich; Jan D'hooge; Koen Van Den Abeele; Edmond Sterpin
Published in: Physics in Medicine and Biology, Vol. 65, no.6, p. 17 (2020), 6, 2020, ISSN 1361-6560
Publisher: -
DOI: 10.1088/1361-6560/ab7506

Ultrasound-assisted investigation of photon triggered vaporization of poly(vinylalcohol) phase-change nanodroplets: A preliminary concept study with dosimetry perspective

Author(s): Yosra Toumia; Roberto Miceli; Fabio Domenici; Sophie V. Heymans; Bram Carlier; Madalina Cociorb; Letizia Oddo; Piero Rossi; Rolando Maria D'Angellilo; Edmond Sterpin; Emiliano D'Agostino; Koen Van Den Abeele; Jan D'hooge; Gaio Paradossi
Published in: Physica Medica, Vol. 89, p. 232-242 (2021), 3, 2021, ISSN 1120-1797
Publisher: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.08.006

Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification

Author(s): Gonzalo Collado-Lara; Sophie V. Heymans; Sophie V. Heymans; Marta Rovituso; Bram Carlier; Yosra Toumia; Martin D. Verweij; Martin D. Verweij; Gaio Paradossi; Edmond Sterpin; Hendrik J. Vos; Hendrik J. Vos; Jan D'hooge; Nico de Jong; Nico de Jong; Koen Van Den Abeele; Verya Daeichin
Published in: VOLUME=48;ISSUE=1;ISSN=0301-5629;TITLE=Ultrasound in Medicine & Biology, 3, 2022, ISSN 0301-5629
Publisher: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2021.09.009

Phase Change Ultrasound Contrast Agents with a Photopolymerized Diacetylene Shell

Author(s): Toumia, Y.; Cerroni, B.; Domenici, F.; Lange, H.; Bianchi, L.; Cociorb, M.; Brasili, F.; Chiessi, E.; D' Agostino, E.; Van Den Abeele, K.; Heymans, S. V.; D' Hooge, J.; Paradossi, G.
Published in: Langmuir, 5, 2019, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01160