mRNA cap regulation and function in CD8 T cells

Project Information

TCAPS

Grant agreement ID: 769080

DOI

10.3030/769080

Project closed

EC signature date 18 February 2018

Start date 1 May 2018

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 991 387,00

EU contribution

€ 1 991 387,00

Coordinated by

BEATSON INSTITUTE FOR CANCER RESEARCH LBG
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

RNA and DNA seq data will be made publicly available via GEO database or latest relevant databasesDeposit research data needed to validate the results presented in scientific publications including associated metadata in the repository as soon as possible Also other data for instance data not directly attributable to a publication or raw data including associated metadata should be depositedTake measures to enable any third party to access mine exploit reproduce and disseminate free of charge for any user this research data for instance by attaching a Creative Commons Attribution Licence CC BY to the data deposited or by waiving all interests associated to copyright and database protection using the CC0 toolProvide information via the chosen repository about the tools available in order for the researchers to validate the results eg specialised software or software code algorithms and analysis protocols Where possible these tools or instruments should be provided

Publications

Peer reviewed articles (8)

RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression

Author(s): Katarzyna Knop, Carolina Gomez-Moreira, Alison Galloway, Dimitrinka Ditsova, Victoria H Cowling
Published in: Discovery Immunology, Issue Volume 3, Issue 1, 2024, Page(s) kyad021, ISSN 2754-2483
Publisher: Oxford University Press
DOI: 10.1093/discim/kyad021

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.

Author(s): Lesley-Anne Pearson; Charlotte J. Green; De Lin; Alain-Pierre Petit; David W. Gray; Victoria H. Cowling; Euan A. F. Fordyce
Published in: SLAS Discovery, Issue 24725552, 2021, Page(s) 749-756, ISSN 2472-5552
Publisher: Elsevier
DOI: 10.1177/24725552211000652

CAP-MAP: Cap Analysis Protocol with Minimal Analyte Processing, a rapid and sensitive approach to analysing mRNA cap structures

Author(s): Alison Galloway; Abdelmadjid Atrih; Renata Grzela; Edward Darzynkiewicz; Michael A. J. Ferguson; Victoria H. Cowling
Published in: Open Biology, Issue 20462441, 2020, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1101/2019.12.29.890368

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations

Author(s): Juan A Bueren-Calabuig, Marcus G. Bage, Victoria H Cowling, Andrei V Pisliakov
Published in: Nucleic Acids Research, Issue 47 (16), 2019, Page(s) 8675–8692, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz613

mRNA cap regulation in mammalian cell function and fate

Author(s): Alison Galloway, Victoria H. Cowling
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Issue 1862/3, 2019, Page(s) 270-279, ISSN 1874-9399
Publisher: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.09.011

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

Author(s): Victoria H. Cowling
Published in: Trends in Biochemical Sciences, Issue 44/3, 2019, Page(s) 183-185, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.002

A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation.

Author(s): Marcus G Bage; Rajaei Almohammed; Victoria H. Cowling; Andrei V. Pisliakov
Published in: Nucleic Acids Research, Issue 13624962, 2021, Page(s) 3109-3126, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab130

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Author(s): Alison Galloway, Aneesa Kaskar, Dimitrinka Ditsova, Abdelmadjid Atrih, Harunori Yoshikawa, Carolina Gomez-Moreira, Olga Suska, Marcin Warminski, Renata Grzela, Angus I Lamond, Edward Darzynkiewicz, Jacek Jemielity, Victoria H Cowling
Published in: Nucleic Acids Research, Issue not available yet, 2021, Page(s) not available yet, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab465