mRNA cap regulation and function in CD8 T cells

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RNA and DNA seq data will be made publicly available via GEO database or latest relevant databasesDeposit research data needed to validate the results presented in scientific publications including associated metadata in the repository as soon as possible Also other data for instance data not directly attributable to a publication or raw data including associated metadata should be depositedTake measures to enable any third party to access mine exploit reproduce and disseminate free of charge for any user this research data for instance by attaching a Creative Commons Attribution Licence CC BY to the data deposited or by waiving all interests associated to copyright and database protection using the CC0 toolProvide information via the chosen repository about the tools available in order for the researchers to validate the results eg specialised software or software code algorithms and analysis protocols Where possible these tools or instruments should be provided

Publications

RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression

Auteurs: Katarzyna Knop, Carolina Gomez-Moreira, Alison Galloway, Dimitrinka Ditsova, Victoria H Cowling
Publié dans: Discovery Immunology, Numéro Volume 3, Numéro 1, 2024, Page(s) kyad021, ISSN 2754-2483
Éditeur: Oxford University Press
DOI: 10.1093/discim/kyad021

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.

Auteurs: Lesley-Anne Pearson; Charlotte J. Green; De Lin; Alain-Pierre Petit; David W. Gray; Victoria H. Cowling; Euan A. F. Fordyce
Publié dans: SLAS Discovery, Numéro 24725552, 2021, Page(s) 749-756, ISSN 2472-5552
Éditeur: Elsevier
DOI: 10.1177/24725552211000652

CAP-MAP: Cap Analysis Protocol with Minimal Analyte Processing, a rapid and sensitive approach to analysing mRNA cap structures

Auteurs: Alison Galloway; Abdelmadjid Atrih; Renata Grzela; Edward Darzynkiewicz; Michael A. J. Ferguson; Victoria H. Cowling
Publié dans: Open Biology, Numéro 20462441, 2020, ISSN 2046-2441
Éditeur: Royal Society Publishing
DOI: 10.1101/2019.12.29.890368

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations

Auteurs: Juan A Bueren-Calabuig, Marcus G. Bage, Victoria H Cowling, Andrei V Pisliakov
Publié dans: Nucleic Acids Research, Numéro 47 (16), 2019, Page(s) 8675–8692, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkz613

mRNA cap regulation in mammalian cell function and fate

Auteurs: Alison Galloway, Victoria H. Cowling
Publié dans: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numéro 1862/3, 2019, Page(s) 270-279, ISSN 1874-9399
Éditeur: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.09.011

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

Auteurs: Victoria H. Cowling
Publié dans: Trends in Biochemical Sciences, Numéro 44/3, 2019, Page(s) 183-185, ISSN 0968-0004
Éditeur: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.002

A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation.

Auteurs: Marcus G Bage; Rajaei Almohammed; Victoria H. Cowling; Andrei V. Pisliakov
Publié dans: Nucleic Acids Research, Numéro 13624962, 2021, Page(s) 3109-3126, ISSN 1362-4962
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab130

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Auteurs: Alison Galloway, Aneesa Kaskar, Dimitrinka Ditsova, Abdelmadjid Atrih, Harunori Yoshikawa, Carolina Gomez-Moreira, Olga Suska, Marcin Warminski, Renata Grzela, Angus I Lamond, Edward Darzynkiewicz, Jacek Jemielity, Victoria H Cowling
Publié dans: Nucleic Acids Research, Numéro not available yet, 2021, Page(s) not available yet, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab465

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