mRNA cap regulation and function in CD8 T cells

Informazioni relative al progetto

TCAPS

ID dell’accordo di sovvenzione: 769080

DOI

10.3030/769080

Progetto chiuso

Data della firma CE 18 Febbraio 2018

Data di avvio 1 Maggio 2018

Data di completamento 30 Aprile 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 991 387,00

Contributo UE

€ 1 991 387,00

Coordinato da

BEATSON INSTITUTE FOR CANCER RESEARCH LBG
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

RNA and DNA seq data will be made publicly available via GEO database or latest relevant databasesDeposit research data needed to validate the results presented in scientific publications including associated metadata in the repository as soon as possible Also other data for instance data not directly attributable to a publication or raw data including associated metadata should be depositedTake measures to enable any third party to access mine exploit reproduce and disseminate free of charge for any user this research data for instance by attaching a Creative Commons Attribution Licence CC BY to the data deposited or by waiving all interests associated to copyright and database protection using the CC0 toolProvide information via the chosen repository about the tools available in order for the researchers to validate the results eg specialised software or software code algorithms and analysis protocols Where possible these tools or instruments should be provided

Pubblicazioni

Peer reviewed articles (8)

RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression

Autori: Katarzyna Knop, Carolina Gomez-Moreira, Alison Galloway, Dimitrinka Ditsova, Victoria H Cowling
Pubblicato in: Discovery Immunology, Numero Volume 3, Numero 1, 2024, Pagina/e kyad021, ISSN 2754-2483
Editore: Oxford University Press
DOI: 10.1093/discim/kyad021

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.

Autori: Lesley-Anne Pearson; Charlotte J. Green; De Lin; Alain-Pierre Petit; David W. Gray; Victoria H. Cowling; Euan A. F. Fordyce
Pubblicato in: SLAS Discovery, Numero 24725552, 2021, Pagina/e 749-756, ISSN 2472-5552
Editore: Elsevier
DOI: 10.1177/24725552211000652

CAP-MAP: Cap Analysis Protocol with Minimal Analyte Processing, a rapid and sensitive approach to analysing mRNA cap structures

Autori: Alison Galloway; Abdelmadjid Atrih; Renata Grzela; Edward Darzynkiewicz; Michael A. J. Ferguson; Victoria H. Cowling
Pubblicato in: Open Biology, Numero 20462441, 2020, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1101/2019.12.29.890368

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations

Autori: Juan A Bueren-Calabuig, Marcus G. Bage, Victoria H Cowling, Andrei V Pisliakov
Pubblicato in: Nucleic Acids Research, Numero 47 (16), 2019, Pagina/e 8675–8692, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz613

mRNA cap regulation in mammalian cell function and fate

Autori: Alison Galloway, Victoria H. Cowling
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numero 1862/3, 2019, Pagina/e 270-279, ISSN 1874-9399
Editore: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.09.011

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

Autori: Victoria H. Cowling
Pubblicato in: Trends in Biochemical Sciences, Numero 44/3, 2019, Pagina/e 183-185, ISSN 0968-0004
Editore: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.002

A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation.

Autori: Marcus G Bage; Rajaei Almohammed; Victoria H. Cowling; Andrei V. Pisliakov
Pubblicato in: Nucleic Acids Research, Numero 13624962, 2021, Pagina/e 3109-3126, ISSN 1362-4962
Editore: Oxford University Press
DOI: 10.1093/nar/gkab130

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Autori: Alison Galloway, Aneesa Kaskar, Dimitrinka Ditsova, Abdelmadjid Atrih, Harunori Yoshikawa, Carolina Gomez-Moreira, Olga Suska, Marcin Warminski, Renata Grzela, Angus I Lamond, Edward Darzynkiewicz, Jacek Jemielity, Victoria H Cowling
Pubblicato in: Nucleic Acids Research, Numero not available yet, 2021, Pagina/e not available yet, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab465