mRNA cap regulation and function in CD8 T cells

Información del proyecto

TCAPS

Identificador del acuerdo de subvención: 769080

DOI

10.3030/769080

Proyecto cerrado

Fecha de la firma de la CE 18 Febrero 2018

Fecha de inicio 1 Mayo 2018

Fecha de finalización 30 Abril 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 991 387,00

Aportación de la UE

€ 1 991 387,00

Coordinado por

BEATSON INSTITUTE FOR CANCER RESEARCH LBG
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

RNA and DNA seq data will be made publicly available via GEO database or latest relevant databasesDeposit research data needed to validate the results presented in scientific publications including associated metadata in the repository as soon as possible Also other data for instance data not directly attributable to a publication or raw data including associated metadata should be depositedTake measures to enable any third party to access mine exploit reproduce and disseminate free of charge for any user this research data for instance by attaching a Creative Commons Attribution Licence CC BY to the data deposited or by waiving all interests associated to copyright and database protection using the CC0 toolProvide information via the chosen repository about the tools available in order for the researchers to validate the results eg specialised software or software code algorithms and analysis protocols Where possible these tools or instruments should be provided

Publicaciones

Peer reviewed articles (8)

RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression

Autores: Katarzyna Knop, Carolina Gomez-Moreira, Alison Galloway, Dimitrinka Ditsova, Victoria H Cowling
Publicado en: Discovery Immunology, Edición Volume 3, Edición 1, 2024, Página(s) kyad021, ISSN 2754-2483
Editor: Oxford University Press
DOI: 10.1093/discim/kyad021

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.

Autores: Lesley-Anne Pearson; Charlotte J. Green; De Lin; Alain-Pierre Petit; David W. Gray; Victoria H. Cowling; Euan A. F. Fordyce
Publicado en: SLAS Discovery, Edición 24725552, 2021, Página(s) 749-756, ISSN 2472-5552
Editor: Elsevier
DOI: 10.1177/24725552211000652

CAP-MAP: Cap Analysis Protocol with Minimal Analyte Processing, a rapid and sensitive approach to analysing mRNA cap structures

Autores: Alison Galloway; Abdelmadjid Atrih; Renata Grzela; Edward Darzynkiewicz; Michael A. J. Ferguson; Victoria H. Cowling
Publicado en: Open Biology, Edición 20462441, 2020, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1101/2019.12.29.890368

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations

Autores: Juan A Bueren-Calabuig, Marcus G. Bage, Victoria H Cowling, Andrei V Pisliakov
Publicado en: Nucleic Acids Research, Edición 47 (16), 2019, Página(s) 8675–8692, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz613

mRNA cap regulation in mammalian cell function and fate

Autores: Alison Galloway, Victoria H. Cowling
Publicado en: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Edición 1862/3, 2019, Página(s) 270-279, ISSN 1874-9399
Editor: Elsevier BV
DOI: 10.1016/j.bbagrm.2018.09.011

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

Autores: Victoria H. Cowling
Publicado en: Trends in Biochemical Sciences, Edición 44/3, 2019, Página(s) 183-185, ISSN 0968-0004
Editor: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.002

A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation.

Autores: Marcus G Bage; Rajaei Almohammed; Victoria H. Cowling; Andrei V. Pisliakov
Publicado en: Nucleic Acids Research, Edición 13624962, 2021, Página(s) 3109-3126, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkab130

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Autores: Alison Galloway, Aneesa Kaskar, Dimitrinka Ditsova, Abdelmadjid Atrih, Harunori Yoshikawa, Carolina Gomez-Moreira, Olga Suska, Marcin Warminski, Renata Grzela, Angus I Lamond, Edward Darzynkiewicz, Jacek Jemielity, Victoria H Cowling
Publicado en: Nucleic Acids Research, Edición not available yet, 2021, Página(s) not available yet, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab465