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The integration of cell signalling and mechanical forces in vascular morphology


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Decoding the PTM-switchboard of Notch

Author(s): Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1866/12, 2019, Page(s) 118507, ISSN 0167-4889
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Author(s): Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Published in: The FASEB Journal, 2020, ISSN 0892-6638
DOI: 10.1096/fj.202001627r

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Author(s): Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Published in: Lab on a Chip, Issue 18/11, 2018, Page(s) 1607-1620, ISSN 1473-0197
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Author(s): R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Published in: Integrative Biology, Issue 10/11, 2018, Page(s) 719-726, ISSN 1757-9694
DOI: 10.1039/c8ib00036k

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Author(s): Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Proceedings of the National Academy of Sciences, Issue 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
DOI: 10.1073/pnas.1715277115

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Author(s): Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Author(s): Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 36/4, 2020, ISSN 2040-7939
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Author(s): Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Published in: Micromachines, Issue 11/6, 2020, Page(s) 552, ISSN 2072-666X
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Author(s): Sandra Loerakker, Tommaso Ristori
Published in: Current Opinion in Biomedical Engineering, Issue 15, 2020, Page(s) 1-9, ISSN 2468-4511
DOI: 10.1016/j.cobme.2019.12.007