The integration of cell signalling and mechanical forces in vascular morphology

Deliverables

Update on the data management plan of the project

Publications

SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells

Author(s): Dylan Mostert, Janine Grolleman, Mark C. van Turnhout, Bart G. W. Groenen, Vito Conte, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten
Published in: Frontiers in Cell and Developmental Biology, 2023, ISSN 2296-634X
Publisher: Switzerland
DOI: 10.3389/fcell.2023.1267822

Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Author(s): Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-44835-8

Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature

Author(s): Diosángeles Soto Véliz, Kai-Lan Lin, Cecilia Sahlgren
Published in: Smart Medicine, 2023, ISSN 2751-1871
Publisher: Wiley Open Access
DOI: 10.1002/smmd.20220030

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Author(s): Cansu Karakaya, Mark C. Van Turnhout, Valery L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Sandra Loerakker
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.910503

A multiscale computational model of arterial growth and remodeling including Notch signaling

Author(s): Jordy G. M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P. T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-023-01697-3

Mechanical regulation of the Notch signaling pathway

Author(s): Freddy Suarez Rodriguez, Sami Sanlidag, Cecilia Sahlgren
Published in: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2023.102244

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

Author(s): Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
Published in: Journal of Cell Science, Issue 133/24, 2020, Page(s) jcs250738, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250738

Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders

Author(s): Tommaso Ristori, Marika Sjöqvist, Cecilia M. Sahlgren
Published in: Tissue Engineering Part C: Methods, Issue 27/3, 2021, Page(s) 167-176, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2020.0327

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Author(s): Jordy G. M. van Asten, Tommaso Ristori, David R. Nolan, Caitríona Lally, Frank P. T. Baaijens, Cecilia M. Sahlgren, Sandra Loerakker
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105325

Decoding the PTM-switchboard of Notch

Author(s): Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1866/12, 2019, Page(s) 118507, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Author(s): Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Published in: The FASEB Journal, 2020, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001627r

Engineering tissue morphogenesis: taking it up a Notch

Author(s): Laura A. Tiemeijer, Sami Sanlidag, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Trends in Biotechnology, Issue 01677799, 2022, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2022.01.007

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Author(s): Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Published in: Lab on a Chip, Issue 18/11, 2018, Page(s) 1607-1620, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Author(s): R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Published in: Integrative Biology, Issue 10/11, 2018, Page(s) 719-726, ISSN 1757-9694
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ib00036k

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Author(s): Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Author(s): Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 36/4, 2020, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Author(s): Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Published in: Micromachines, Issue 11/6, 2020, Page(s) 552, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Author(s): Sandra Loerakker, Tommaso Ristori
Published in: Current Opinion in Biomedical Engineering, Issue 15, 2020, Page(s) 1-9, ISSN 2468-4511
Publisher: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Author(s): Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Proceedings of the National Academy of Sciences, Issue 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts

Author(s): Maaike Bril, Aref Saberi, Ignasi Jorba, Mark C. van Turnhout, Cecilia M. Sahlgren, Carlijn V.C. Bouten, Albert P.H.J. Schenning, Nicholas A. Kurniawan
Published in: Advanced Science, 2023, ISSN 2198-3844
Publisher: Wiley Open Access
DOI: 10.1002/advs.202303136

Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

Author(s): Cansu Karakaya, Jordy G. M. van Asten, Tommaso Ristori, Cecilia M. Sahlgren, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-021-01521-w

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

Author(s): Laura A. Timeijer, Tommaso Ristori, Oscar M. J. A. Stassen, Jaakko J. Ahlberg, Jonne J. J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: iScience, Issue 25890042, 2022, ISSN 2589-0042
Publisher: Cell Press / Elsevier
DOI: 10.1016/j.isci.2022.104306

Deliverables

Publications

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