The integration of cell signalling and mechanical forces in vascular morphology

Deliverables

Open Research Data Pilot (1)

Data management plan

Update on the data management plan of the project

Publications

Peer reviewed articles (13)

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

Author(s): Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
Published in: Journal of Cell Science, 133/24, 2020, Page(s) jcs250738, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250738

Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders

Author(s): Tommaso Ristori, Marika Sjöqvist, Cecilia M. Sahlgren
Published in: Tissue Engineering Part C: Methods, 27/3, 2021, Page(s) 167-176, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2020.0327

Decoding the PTM-switchboard of Notch

Author(s): Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1866/12, 2019, Page(s) 118507, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Author(s): Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Published in: The FASEB Journal, 2020, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001627r

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Author(s): Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Published in: Lab on a Chip, 18/11, 2018, Page(s) 1607-1620, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Author(s): R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Published in: Integrative Biology, 10/11, 2018, Page(s) 719-726, ISSN 1757-9694
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ib00036k

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Author(s): Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Proceedings of the National Academy of Sciences, 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Author(s): Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Author(s): Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Published in: International Journal for Numerical Methods in Biomedical Engineering, 36/4, 2020, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Author(s): Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Published in: Micromachines, 11/6, 2020, Page(s) 552, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Author(s): Sandra Loerakker, Tommaso Ristori
Published in: Current Opinion in Biomedical Engineering, 15, 2020, Page(s) 1-9, ISSN 2468-4511
Publisher: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Author(s): Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Proceedings of the National Academy of Sciences, 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

Author(s): Cansu Karakaya, Jordy G. M. van Asten, Tommaso Ristori, Cecilia M. Sahlgren, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-021-01521-w