The integration of cell signalling and mechanical forces in vascular morphology

Risultati finali

Update on the data management plan of the project

Pubblicazioni

SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells

Autori: Dylan Mostert, Janine Grolleman, Mark C. van Turnhout, Bart G. W. Groenen, Vito Conte, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten
Pubblicato in: Frontiers in Cell and Developmental Biology, 2023, ISSN 2296-634X
Editore: Switzerland
DOI: 10.3389/fcell.2023.1267822

Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Autori: Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten
Pubblicato in: Scientific Reports, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-44835-8

Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature

Autori: Diosángeles Soto Véliz, Kai-Lan Lin, Cecilia Sahlgren
Pubblicato in: Smart Medicine, 2023, ISSN 2751-1871
Editore: Wiley Open Access
DOI: 10.1002/smmd.20220030

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Autori: Cansu Karakaya, Mark C. Van Turnhout, Valery L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Sandra Loerakker
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.910503

A multiscale computational model of arterial growth and remodeling including Notch signaling

Autori: Jordy G. M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P. T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Pubblicato in: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Editore: Springer Verlag
DOI: 10.1007/s10237-023-01697-3

Mechanical regulation of the Notch signaling pathway

Autori: Freddy Suarez Rodriguez, Sami Sanlidag, Cecilia Sahlgren
Pubblicato in: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2023.102244

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

Autori: Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
Pubblicato in: Journal of Cell Science, Numero 133/24, 2020, Pagina/e jcs250738, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250738

Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders

Autori: Tommaso Ristori, Marika Sjöqvist, Cecilia M. Sahlgren
Pubblicato in: Tissue Engineering Part C: Methods, Numero 27/3, 2021, Pagina/e 167-176, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2020.0327

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Autori: Jordy G. M. van Asten, Tommaso Ristori, David R. Nolan, Caitríona Lally, Frank P. T. Baaijens, Cecilia M. Sahlgren, Sandra Loerakker
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105325

Decoding the PTM-switchboard of Notch

Autori: Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Numero 1866/12, 2019, Pagina/e 118507, ISSN 0167-4889
Editore: Elsevier BV
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Autori: Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Pubblicato in: The FASEB Journal, 2020, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001627r

Engineering tissue morphogenesis: taking it up a Notch

Autori: Laura A. Tiemeijer, Sami Sanlidag, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Pubblicato in: Trends in Biotechnology, Numero 01677799, 2022, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2022.01.007

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Autori: Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Pubblicato in: Lab on a Chip, Numero 18/11, 2018, Pagina/e 1607-1620, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Autori: R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Pubblicato in: Integrative Biology, Numero 10/11, 2018, Pagina/e 719-726, ISSN 1757-9694
Editore: Royal Society of Chemistry
DOI: 10.1039/c8ib00036k

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Autori: Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Autori: Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Pubblicato in: International Journal for Numerical Methods in Biomedical Engineering, Numero 36/4, 2020, ISSN 2040-7939
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Autori: Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Pubblicato in: Micromachines, Numero 11/6, 2020, Pagina/e 552, ISSN 2072-666X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Autori: Sandra Loerakker, Tommaso Ristori
Pubblicato in: Current Opinion in Biomedical Engineering, Numero 15, 2020, Pagina/e 1-9, ISSN 2468-4511
Editore: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Autori: Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/16, 2018, Pagina/e E3682-E3691, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts

Autori: Maaike Bril, Aref Saberi, Ignasi Jorba, Mark C. van Turnhout, Cecilia M. Sahlgren, Carlijn V.C. Bouten, Albert P.H.J. Schenning, Nicholas A. Kurniawan
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: Wiley Open Access
DOI: 10.1002/advs.202303136

Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

Autori: Cansu Karakaya, Jordy G. M. van Asten, Tommaso Ristori, Cecilia M. Sahlgren, Sandra Loerakker
Pubblicato in: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Editore: Springer Verlag
DOI: 10.1007/s10237-021-01521-w

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

Autori: Laura A. Timeijer, Tommaso Ristori, Oscar M. J. A. Stassen, Jaakko J. Ahlberg, Jonne J. J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Pubblicato in: iScience, Numero 25890042, 2022, ISSN 2589-0042
Editore: Cell Press / Elsevier
DOI: 10.1016/j.isci.2022.104306

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