The integration of cell signalling and mechanical forces in vascular morphology

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Update on the data management plan of the project

Publications

SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells

Auteurs: Dylan Mostert, Janine Grolleman, Mark C. van Turnhout, Bart G. W. Groenen, Vito Conte, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten
Publié dans: Frontiers in Cell and Developmental Biology, 2023, ISSN 2296-634X
Éditeur: Switzerland
DOI: 10.3389/fcell.2023.1267822

Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Auteurs: Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-44835-8

Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature

Auteurs: Diosángeles Soto Véliz, Kai-Lan Lin, Cecilia Sahlgren
Publié dans: Smart Medicine, 2023, ISSN 2751-1871
Éditeur: Wiley Open Access
DOI: 10.1002/smmd.20220030

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Auteurs: Cansu Karakaya, Mark C. Van Turnhout, Valery L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Sandra Loerakker
Publié dans: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.910503

A multiscale computational model of arterial growth and remodeling including Notch signaling

Auteurs: Jordy G. M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P. T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Publié dans: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Éditeur: Springer Verlag
DOI: 10.1007/s10237-023-01697-3

Mechanical regulation of the Notch signaling pathway

Auteurs: Freddy Suarez Rodriguez, Sami Sanlidag, Cecilia Sahlgren
Publié dans: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Éditeur: Elsevier BV
DOI: 10.1016/j.ceb.2023.102244

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

Auteurs: Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
Publié dans: Journal of Cell Science, Numéro 133/24, 2020, Page(s) jcs250738, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250738

Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders

Auteurs: Tommaso Ristori, Marika Sjöqvist, Cecilia M. Sahlgren
Publié dans: Tissue Engineering Part C: Methods, Numéro 27/3, 2021, Page(s) 167-176, ISSN 1937-3384
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2020.0327

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Auteurs: Jordy G. M. van Asten, Tommaso Ristori, David R. Nolan, Caitríona Lally, Frank P. T. Baaijens, Cecilia M. Sahlgren, Sandra Loerakker
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105325

Decoding the PTM-switchboard of Notch

Auteurs: Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Numéro 1866/12, 2019, Page(s) 118507, ISSN 0167-4889
Éditeur: Elsevier BV
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Auteurs: Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Publié dans: The FASEB Journal, 2020, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001627r

Engineering tissue morphogenesis: taking it up a Notch

Auteurs: Laura A. Tiemeijer, Sami Sanlidag, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publié dans: Trends in Biotechnology, Numéro 01677799, 2022, ISSN 0167-7799
Éditeur: Elsevier BV
DOI: 10.1016/j.tibtech.2022.01.007

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Auteurs: Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Publié dans: Lab on a Chip, Numéro 18/11, 2018, Page(s) 1607-1620, ISSN 1473-0197
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Auteurs: R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Publié dans: Integrative Biology, Numéro 10/11, 2018, Page(s) 719-726, ISSN 1757-9694
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8ib00036k

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Auteurs: Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Auteurs: Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, Numéro 36/4, 2020, ISSN 2040-7939
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Auteurs: Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Publié dans: Micromachines, Numéro 11/6, 2020, Page(s) 552, ISSN 2072-666X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Auteurs: Sandra Loerakker, Tommaso Ristori
Publié dans: Current Opinion in Biomedical Engineering, Numéro 15, 2020, Page(s) 1-9, ISSN 2468-4511
Éditeur: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Auteurs: Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts

Auteurs: Maaike Bril, Aref Saberi, Ignasi Jorba, Mark C. van Turnhout, Cecilia M. Sahlgren, Carlijn V.C. Bouten, Albert P.H.J. Schenning, Nicholas A. Kurniawan
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: Wiley Open Access
DOI: 10.1002/advs.202303136

Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

Auteurs: Cansu Karakaya, Jordy G. M. van Asten, Tommaso Ristori, Cecilia M. Sahlgren, Sandra Loerakker
Publié dans: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Éditeur: Springer Verlag
DOI: 10.1007/s10237-021-01521-w

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

Auteurs: Laura A. Timeijer, Tommaso Ristori, Oscar M. J. A. Stassen, Jaakko J. Ahlberg, Jonne J. J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publié dans: iScience, Numéro 25890042, 2022, ISSN 2589-0042
Éditeur: Cell Press / Elsevier
DOI: 10.1016/j.isci.2022.104306

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