The integration of cell signalling and mechanical forces in vascular morphology

Resultado final

Update on the data management plan of the project

Publicaciones

SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells

Autores: Dylan Mostert, Janine Grolleman, Mark C. van Turnhout, Bart G. W. Groenen, Vito Conte, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten
Publicado en: Frontiers in Cell and Developmental Biology, 2023, ISSN 2296-634X
Editor: Switzerland
DOI: 10.3389/fcell.2023.1267822

Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Autores: Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-44835-8

Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature

Autores: Diosángeles Soto Véliz, Kai-Lan Lin, Cecilia Sahlgren
Publicado en: Smart Medicine, 2023, ISSN 2751-1871
Editor: Wiley Open Access
DOI: 10.1002/smmd.20220030

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Autores: Cansu Karakaya, Mark C. Van Turnhout, Valery L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Sandra Loerakker
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.910503

A multiscale computational model of arterial growth and remodeling including Notch signaling

Autores: Jordy G. M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P. T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Publicado en: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Editor: Springer Verlag
DOI: 10.1007/s10237-023-01697-3

Mechanical regulation of the Notch signaling pathway

Autores: Freddy Suarez Rodriguez, Sami Sanlidag, Cecilia Sahlgren
Publicado en: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2023.102244

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

Autores: Oscar M. J. A. Stassen, Tommaso Ristori, Cecilia M. Sahlgren
Publicado en: Journal of Cell Science, Edición 133/24, 2020, Página(s) jcs250738, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.250738

Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders

Autores: Tommaso Ristori, Marika Sjöqvist, Cecilia M. Sahlgren
Publicado en: Tissue Engineering Part C: Methods, Edición 27/3, 2021, Página(s) 167-176, ISSN 1937-3384
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2020.0327

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Autores: Jordy G. M. van Asten, Tommaso Ristori, David R. Nolan, Caitríona Lally, Frank P. T. Baaijens, Cecilia M. Sahlgren, Sandra Loerakker
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Editor: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105325

Decoding the PTM-switchboard of Notch

Autores: Daniel Antfolk, Christian Antila, Kati Kemppainen, Sebastian K.-J. Landor, Cecilia Sahlgren
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Edición 1866/12, 2019, Página(s) 118507, ISSN 0167-4889
Editor: Elsevier BV
DOI: 10.1016/j.bbamcr.2019.07.002

From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

Autores: Marika Sjöqvist, Daniel Antfolk, Freddy Suarez‐Rodriguez, Cecilia Sahlgren
Publicado en: The FASEB Journal, 2020, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001627r

Engineering tissue morphogenesis: taking it up a Notch

Autores: Laura A. Tiemeijer, Sami Sanlidag, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publicado en: Trends in Biotechnology, Edición 01677799, 2022, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2022.01.007

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Autores: Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Publicado en: Lab on a Chip, Edición 18/11, 2018, Página(s) 1607-1620, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/c8lc00286j

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Autores: R. C. H. Driessen, O. M. J. A. Stassen, M. Sjöqvist, F. Suarez Rodriguez, J. Grolleman, C. V. C. Bouten, C. M. Sahlgren
Publicado en: Integrative Biology, Edición 10/11, 2018, Página(s) 719-726, ISSN 1757-9694
Editor: Royal Society of Chemistry
DOI: 10.1039/c8ib00036k

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Autores: Nicole C. A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-48218-w

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Autores: Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Publicado en: International Journal for Numerical Methods in Biomedical Engineering, Edición 36/4, 2020, ISSN 2040-7939
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker

Autores: Rob Driessen, Feihu Zhao, Sandra Hofmann, Carlijn Bouten, Cecilia Sahlgren, Oscar Stassen
Publicado en: Micromachines, Edición 11/6, 2020, Página(s) 552, ISSN 2072-666X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060552

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Autores: Sandra Loerakker, Tommaso Ristori
Publicado en: Current Opinion in Biomedical Engineering, Edición 15, 2020, Página(s) 1-9, ISSN 2468-4511
Editor: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Autores: Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publicado en: Proceedings of the National Academy of Sciences, Edición 115/16, 2018, Página(s) E3682-E3691, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1715277115

Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts

Autores: Maaike Bril, Aref Saberi, Ignasi Jorba, Mark C. van Turnhout, Cecilia M. Sahlgren, Carlijn V.C. Bouten, Albert P.H.J. Schenning, Nicholas A. Kurniawan
Publicado en: Advanced Science, 2023, ISSN 2198-3844
Editor: Wiley Open Access
DOI: 10.1002/advs.202303136

Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

Autores: Cansu Karakaya, Jordy G. M. van Asten, Tommaso Ristori, Cecilia M. Sahlgren, Sandra Loerakker
Publicado en: Biomechanics and Modeling in Mechanobiology, 2021, ISSN 1617-7959
Editor: Springer Verlag
DOI: 10.1007/s10237-021-01521-w

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

Autores: Laura A. Timeijer, Tommaso Ristori, Oscar M. J. A. Stassen, Jaakko J. Ahlberg, Jonne J. J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Publicado en: iScience, Edición 25890042, 2022, ISSN 2589-0042
Editor: Cell Press / Elsevier
DOI: 10.1016/j.isci.2022.104306

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