Gene expression level as a keystone to understanding gene duplication: evolutionary constraints, opportunities, and disease

Project Information

DOUBLE EXPRESS

Grant agreement ID: 771419

DOI

10.3030/771419

Project closed

EC signature date 15 May 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 824 793,75

EU contribution

€ 1 824 793,75

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor

Author(s): Anthony K. Redmond, Dearbhaile Casey, Manu Kumar Gundappa, Daniel J. Macqueen, Aoife McLysaght
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38714-z

Reply to: Available data do not rule out Ctenophora as the sister group to all other Metazoa

Author(s): Anthony K. Redmond, Aoife McLysaght
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36152-5

Evidence from Drosophila Supports Higher Duplicability of Faster Evolving Genes

Author(s): Zoe Vance, Lukasz Niezabitowski, Laurence D Hurst, Aoife McLysaght
Published in: Genome Biology and Evolution, Issue 1, 2022, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evac003

Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution

Author(s): Yoichiro Nakatani, Prashant Shingate, Vydianathan Ravi, Nisha E. Pillai, Aravind Prasad, Aoife McLysaght, Byrappa Venkatesh
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24573-z

Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

Author(s): Nikolaos Vakirlis, Anne-Ruxandra Carvunis, Aoife McLysaght
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.53500

Evidence for sponges as sister to all other animals from partitioned phylogenomics with mixture models and recoding

Author(s): Anthony K. Redmond, Aoife McLysaght
Published in: Nature Communications, Issue 12/1, 2021, Page(s) 1-14, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22074-7

De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences

Author(s): Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O’Donnell, Trey Ideker, Anne-Ruxandra Carvunis
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14500-z

De novo birth of functional microproteins in the human lineage

Author(s): Nikolaos Vakirlis, Zoe Vance, Kate M. Duggan, Aoife McLysaght
Published in: Cell Reports, Issue 41, 2022, Page(s) 111808, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111808

Horizontal transfer of vertebrate vision gene <i>IRBP</i> into the chordate ancestor

Author(s): Anthony K. Redmond, Aoife McLysaght
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2310390120

Other (1)

Evidence for increased stress resistance due to polyploidy from synthetic autotetraploid<i>Caenorhabditis elegans</i>

Author(s): Laetitia Chauve, Emma Bazzani, Clément Verdier, Liam Butler, Martha E. Atimise, Aoibhín McGarry, Aoife McLysaght
Published in: BioRXiV, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.28.546823