Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering

Project Information

INSITE

Grant agreement ID: 772418

DOI 10.3030/772418

Project closed

EC signature date 28 May 2018

Start date 1 September 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 161 750,00

EU contribution € 2 161 750,00

Coordinated by

UNIVERSITE DE LIEGE
Belgium

Publications

Peer reviewed articles (23)

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Author(s): Raphaëlle Lesage; Mauricio N. Ferrao Blanco; Roberto Narcisi; Tim Welting; Gerjo J. V. M. van Osch; Liesbet Geris
Published in: Bmc Biology, Issue 20(1), 2022, Page(s) 253, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-022-01451-8

Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering

Author(s): Mehdi Salar Amoli; Resmi Anand; Mostafa EzEldeen; Liesbet Geris; Reinhilde Jacobs; Veerle Bloemen
Published in: Gels, Issue 10(2), 2024, ISSN 2310-2861
Publisher: MDPI AG
DOI: 10.3390/gels10020140

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

Author(s): Bingbing Liang; Ehsan Sadeghian Dehkord; Dorien Van Hede; Mojtaba Barzegari; Bruno Verlée; Justine Pirson; Grégory Nolens; France Lambert; Liesbet Geris
Published in: Journal of Functional Biomaterials, Issue Vol 14, Iss 12, 2023, Page(s) p 563, ISSN 2079-4983
Publisher: Basel MDPI AG
DOI: 10.3390/jfb14120563

Computational modeling of degradation process of biodegradable magnesium biomaterials

Author(s): Mojtaba Barzegari; Di Mei; Sviatlana V. Lamaka; Liesbet Geris; Liesbet Geris
Published in: Corrosion Science, Issue Volume 190, 2021, Page(s) 109674, ISSN 0010-938X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.corsci.2021.109674

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

Author(s): Laura Lafuente-Gracia; Laura Lafuente-Gracia; Edoardo Borgiani; Edoardo Borgiani; Edoardo Borgiani; Gabriele Nasello; Gabriele Nasello; Gabriele Nasello; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers Media

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Author(s): Mojtaba Barzegari; Liesbet Geris
Published in: Journal of Open Source Education,, Issue 4(40), 2021, Page(s) 89, ISSN 2577-3569
Publisher: Open Journals
DOI: 10.21105/jose.00089

Highly scalable numerical simulation of coupled reaction-diffusion systems with moving interfaces

Author(s): Barzegari, Mojtaba; Geris, Liesbet
Published in: The International Journal of High Performance Computing Applications, Issue 2022;36(2), 2022, Page(s) 198-213, ISSN 1094-3420
Publisher: SAGE Publications
DOI: 10.1177/10943420211045939

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Author(s): Flora T. Musuamba; Ine Skottheim Rusten; Raphaëlle Lesage; Giulia Russo; Roberta Bursi; Luca Emili; Gaby Wangorsch; Efthymios Manolis; Kristin E. Karlsson; Alexander Kulesza; Eulalie Courcelles; Jean-Pierre Boissel; Cécile F. Rousseau; Emmanuelle M. Voisin; Rossana Alessandrello; Nuno Curado; Enrico Dall'Ara; Blanca Rodriguez; Francesco Pappalardo; Liesbet Geris; Liesbet Geris
Published in: CPT Pharmacometrics Syst Pharmacol, Issue 24, 2021, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12669

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

Author(s): Lionel Gillot; Agnes Noel; liesbet geris; Marc Joiret
Published in: Cancer Letters, Issue Volume 497, 2021, Page(s) Pages 154-164, ISSN 0304-3835
Publisher: Elsevier BV
DOI: 10.1016/j.canlet.2020.10.020

Use of Computational Modeling to Study Joint Degeneration: A Review

Author(s): Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Bioengineering and biotechnology
DOI: 10.3389/fbioe.2020.00093

The Third Era of Tissue Engineering: Reversing the Innovation Drivers

Author(s): Liesbet Geris, Ioannis Papantoniou
Published in: Tissue Engineering Part A, Issue 25/11-12, 2019, Page(s) 821-826, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0064

In silico tools predict effects of drugs on bone remodelling

Author(s): Liesbet Geris
Published in: Nature Reviews Rheumatology, 2020, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-0457-6

Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

Author(s): Sébastien Bournonville, Toon Lambrechts, Johan Vanhulst, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Published in: Biotechnology Journal, Issue 14/7, 2019, Page(s) 1800545, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800545

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Author(s): Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00376

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

Author(s): Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou
Published in: Advanced Science, Issue 7/2, 2019, Page(s) 1902295, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.201902295

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning

Author(s): Mohammad Mehrian, Toon Lambrechts, Marina Marechal, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Published in: Cytotherapy, Issue 22/2, 2020, Page(s) 82-90, ISSN 1465-3249
Publisher: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.12.006

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Author(s): Mohammad Mehrian, Liesbet Geris
Published in: Computer Methods in Biomechanics and Biomedical Engineering, Issue 23/7, 2020, Page(s) 285-294, ISSN 1025-5842
Publisher: Taylor & Francis
DOI: 10.1080/10255842.2020.1719081

Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing.

Author(s): Gabriella Nilsson Hall; Iene Rutten; Jeroen Lammertyn; Jens Eberhardt; Liesbet Geris; Liesbet Geris; Frank P. Luyten; Ioannis Papantoniou; Ioannis Papantoniou
Published in: Biofabrication, Issue 13(4), 2021, Page(s) 045025, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ac2208

BioDeg: A finite element software for the simulation of the corrosion and biodegradation process in metallic biomaterials

Author(s): Mojtaba Barzegari; Liesbet Geris
Published in: Journal of Open Source Software, Issue 7(74), 2022, Page(s) 4281, ISSN 2475-9066
Publisher: Open Journals
DOI: 10.21105/joss.04281

Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels

Author(s): Esther Reina-Romo; Sourav Mandal; Paulo Amorim; Paulo Amorim; Veerle Bloemen; Veerle Bloemen; Eleonora Ferraris; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2021.701778

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Author(s): Perez Boerema, Fernando Adrian; Barzegari Shankil, Mojtaba; Geris, Liesbet
Published in: Virtual and Physical Prototyping, Issue Vol 17, Iss 3, 2022, Page(s) 682-699, ISSN 1745-2759
Publisher: Taylor & Francis
DOI: 10.6084/m9.figshare.19387475

Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids

Author(s): Hall, Gabriella Nilsson; Chandrakar, Amit; Pastore, Angela; Ioannidis, Konstantinos; Moisley, Katrina; Cirstea, Matei; Geris, Liesbet; Moroni, Lorenzo; Luyten, Frank P.; Wieringa, Paul; Papantoniou, Ioannis
Published in: Acta Biomaterialia, Issue Vol. 165, 2023, Page(s) pp. 111 - 124, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.037

An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation

Author(s): Ehsan Sadeghian Dehkord; Greet Kerckhofs; Philippe Compère; France Lambert; Liesbet Geris
Published in: Journal of Functional Biomaterials, Issue Vol. 14, no.7, 2023, Page(s) p. 388, ISSN 2079-4983
Publisher: Basel MDPI AG
DOI: 10.3390/jfb14070388