Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering

Project Information

INSITE

Grant agreement ID: 772418

DOI

10.3030/772418

Project closed

EC signature date 28 May 2018

Start date 1 September 2018

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 161 750,00

EU contribution

€ 2 161 750,00

Coordinated by

UNIVERSITE DE LIEGE
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (31)

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Author(s): Raphaëlle Lesage; Mauricio N. Ferrao Blanco; Roberto Narcisi; Tim Welting; Gerjo J. V. M. van Osch; Liesbet Geris
Published in: Bmc Biology, Issue 20(1), 2022, Page(s) 253, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-022-01451-8

Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering

Author(s): Mehdi Salar Amoli; Resmi Anand; Mostafa EzEldeen; Liesbet Geris; Reinhilde Jacobs; Veerle Bloemen
Published in: Gels, Issue 10(2), 2024, ISSN 2310-2861
Publisher: MDPI AG
DOI: 10.3390/gels10020140

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

Author(s): Bingbing Liang; Ehsan Sadeghian Dehkord; Dorien Van Hede; Mojtaba Barzegari; Bruno Verlée; Justine Pirson; Grégory Nolens; France Lambert; Liesbet Geris
Published in: Journal of Functional Biomaterials, Issue Vol 14, Iss 12, 2023, Page(s) p 563, ISSN 2079-4983
Publisher: Basel MDPI AG
DOI: 10.3390/jfb14120563

Computational modeling of degradation process of biodegradable magnesium biomaterials

Author(s): Mojtaba Barzegari; Di Mei; Sviatlana V. Lamaka; Liesbet Geris; Liesbet Geris
Published in: Corrosion Science, Issue Volume 190, 2021, Page(s) 109674, ISSN 0010-938X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.corsci.2021.109674

Cracking the genetic code with neural networks

Author(s): Marc Joiret; Marine Leclercq; Gaspard Lambrechts; Francesca Rapino; Pierre Close; Gilles Louppe; Liesbet Geris; Liesbet Geris; Liesbet Geris
Published in: Front Artificial Intelligence, 2023, ISSN 2624-8212
Publisher: Frontiers Media
DOI: 10.3389/frai.2023.1128153

3D-Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo

Author(s): Dorien Van hede; Bingbing Liang; Sandy Anania; Mojtaba Barzegari; Bruno Verlée; Grégory Nolens; Justine Pirson; Liesbet Geris; France Lambert
Published in: Advanced Functional Materials, 2022, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105002

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

Author(s): Laura Lafuente-Gracia; Laura Lafuente-Gracia; Edoardo Borgiani; Edoardo Borgiani; Edoardo Borgiani; Gabriele Nasello; Gabriele Nasello; Gabriele Nasello; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers Media

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Author(s): Mojtaba Barzegari; Liesbet Geris
Published in: Journal of Open Source Education,, Issue 4(40), 2021, Page(s) 89, ISSN 2577-3569
Publisher: Open Journals
DOI: 10.21105/jose.00089

Highly scalable numerical simulation of coupled reaction-diffusion systems with moving interfaces

Author(s): Barzegari, Mojtaba; Geris, Liesbet
Published in: The International Journal of High Performance Computing Applications, Issue 2022;36(2), 2022, Page(s) 198-213, ISSN 1094-3420
Publisher: SAGE Publications
DOI: 10.1177/10943420211045939

Ribosome exit tunnel electrostatics

Author(s): Joiret, Marc; Kerff, Frederic; Rapino, Francesca; Close, Pierre; Geris, Liesbet
Published in: Phys Rev E., 2022, ISSN 2470-0045
Publisher: American Physical Society
DOI: 10.1103/physreve.105.014409

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Author(s): Flora T. Musuamba; Ine Skottheim Rusten; Raphaëlle Lesage; Giulia Russo; Roberta Bursi; Luca Emili; Gaby Wangorsch; Efthymios Manolis; Kristin E. Karlsson; Alexander Kulesza; Eulalie Courcelles; Jean-Pierre Boissel; Cécile F. Rousseau; Emmanuelle M. Voisin; Rossana Alessandrello; Nuno Curado; Enrico Dall'Ara; Blanca Rodriguez; Francesco Pappalardo; Liesbet Geris; Liesbet Geris
Published in: CPT Pharmacometrics Syst Pharmacol, Issue 24, 2021, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12669

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

Author(s): Lionel Gillot; Agnes Noel; liesbet geris; Marc Joiret
Published in: Cancer Letters, Issue Volume 497, 2021, Page(s) Pages 154-164, ISSN 0304-3835
Publisher: Elsevier BV
DOI: 10.1016/j.canlet.2020.10.020

Use of Computational Modeling to Study Joint Degeneration: A Review

Author(s): Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Bioengineering and biotechnology
DOI: 10.3389/fbioe.2020.00093

The Third Era of Tissue Engineering: Reversing the Innovation Drivers

Author(s): Liesbet Geris, Ioannis Papantoniou
Published in: Tissue Engineering Part A, Issue 25/11-12, 2019, Page(s) 821-826, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0064

In silico tools predict effects of drugs on bone remodelling

Author(s): Liesbet Geris
Published in: Nature Reviews Rheumatology, 2020, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-0457-6

Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

Author(s): Sébastien Bournonville, Toon Lambrechts, Johan Vanhulst, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Published in: Biotechnology Journal, Issue 14/7, 2019, Page(s) 1800545, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800545

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Author(s): Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00376

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

Author(s): Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou
Published in: Advanced Science, Issue 7/2, 2019, Page(s) 1902295, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.201902295

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning

Author(s): Mohammad Mehrian, Toon Lambrechts, Marina Marechal, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Published in: Cytotherapy, Issue 22/2, 2020, Page(s) 82-90, ISSN 1465-3249
Publisher: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.12.006

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Author(s): Mohammad Mehrian, Liesbet Geris
Published in: Computer Methods in Biomechanics and Biomedical Engineering, Issue 23/7, 2020, Page(s) 285-294, ISSN 1025-5842
Publisher: Taylor & Francis
DOI: 10.1080/10255842.2020.1719081

A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome

Author(s): Marc Joiret; Francesca Rapino; Pierre Close; Liesbet Geris
Published in: Computational and Structural Biotechnology Journal, 2023, ISSN 2001-0370
Publisher: Elsevier BV
DOI: 10.1101/2022.03.07.483325

An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

Author(s): Sakshi Khurana; Stefano Schivo; Stefano Schivo; Jacqueline R. M. Plass; Nikolas Mersinis; Jetse Scholma; Johan Kerkhofs; Leilei Zhong; Jaco van de Pol; Jaco van de Pol; Rom Langerak; Liesbet Geris; Marcel Karperien; Janine N. Post
Published in: Frontiers Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2021.732917

In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies

Author(s): Sophie Bekisz,Louis Baudin, Florence Buntinx, Agnès Noëlv, Liesbet Geris
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061525

Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing.

Author(s): Gabriella Nilsson Hall; Iene Rutten; Jeroen Lammertyn; Jens Eberhardt; Liesbet Geris; Liesbet Geris; Frank P. Luyten; Ioannis Papantoniou; Ioannis Papantoniou
Published in: Biofabrication, Issue 13(4), 2021, Page(s) 045025, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ac2208

BioDeg: A finite element software for the simulation of the corrosion and biodegradation process in metallic biomaterials

Author(s): Mojtaba Barzegari; Liesbet Geris
Published in: Journal of Open Source Software, Issue 7(74), 2022, Page(s) 4281, ISSN 2475-9066
Publisher: Open Journals
DOI: 10.21105/joss.04281

The development of a 3D printable chitosan-based copolymer with tunable properties for dentoalveolar regeneration.

Author(s): Mehdi Salar Amoli, Resmi Anand, Mostafa EzEldeen, Paulo Amorim, Liesbet Geris, Reinhilde Jacobs, Veerle Bloemen
Published in: Carbohydrate Polymers, 2022, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2022.119441

Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels

Author(s): Esther Reina-Romo; Sourav Mandal; Paulo Amorim; Paulo Amorim; Veerle Bloemen; Veerle Bloemen; Eleonora Ferraris; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2021.701778

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Author(s): Perez Boerema, Fernando Adrian; Barzegari Shankil, Mojtaba; Geris, Liesbet
Published in: Virtual and Physical Prototyping, Issue Vol 17, Iss 3, 2022, Page(s) 682-699, ISSN 1745-2759
Publisher: Taylor & Francis
DOI: 10.6084/m9.figshare.19387475

Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

Author(s): Sophie Bekisz, Liesbet Geris
Published in: Journal of Computational Science, 2020, ISSN 1877-7503
Publisher: Elsevier BV
DOI: 10.1016/j.jocs.2020.101198

Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids

Author(s): Hall, Gabriella Nilsson; Chandrakar, Amit; Pastore, Angela; Ioannidis, Konstantinos; Moisley, Katrina; Cirstea, Matei; Geris, Liesbet; Moroni, Lorenzo; Luyten, Frank P.; Wieringa, Paul; Papantoniou, Ioannis
Published in: Acta Biomaterialia, Issue Vol. 165, 2023, Page(s) pp. 111 - 124, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.037

An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation

Author(s): Ehsan Sadeghian Dehkord; Greet Kerckhofs; Philippe Compère; France Lambert; Liesbet Geris
Published in: Journal of Functional Biomaterials, Issue Vol. 14, no.7, 2023, Page(s) p. 388, ISSN 2079-4983
Publisher: Basel MDPI AG
DOI: 10.3390/jfb14070388