Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering

Información del proyecto

INSITE

Identificador del acuerdo de subvención: 772418

DOI

10.3030/772418

Proyecto cerrado

Fecha de la firma de la CE 28 Mayo 2018

Fecha de inicio 1 Septiembre 2018

Fecha de finalización 31 Agosto 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 161 750,00

Aportación de la UE

€ 2 161 750,00

Coordinado por

UNIVERSITE DE LIEGE
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (31)

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Autores: Raphaëlle Lesage; Mauricio N. Ferrao Blanco; Roberto Narcisi; Tim Welting; Gerjo J. V. M. van Osch; Liesbet Geris
Publicado en: Bmc Biology, Edición 20(1), 2022, Página(s) 253, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-022-01451-8

Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering

Autores: Mehdi Salar Amoli; Resmi Anand; Mostafa EzEldeen; Liesbet Geris; Reinhilde Jacobs; Veerle Bloemen
Publicado en: Gels, Edición 10(2), 2024, ISSN 2310-2861
Editor: MDPI AG
DOI: 10.3390/gels10020140

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

Autores: Bingbing Liang; Ehsan Sadeghian Dehkord; Dorien Van Hede; Mojtaba Barzegari; Bruno Verlée; Justine Pirson; Grégory Nolens; France Lambert; Liesbet Geris
Publicado en: Journal of Functional Biomaterials, Edición Vol 14, Iss 12, 2023, Página(s) p 563, ISSN 2079-4983
Editor: Basel MDPI AG
DOI: 10.3390/jfb14120563

Computational modeling of degradation process of biodegradable magnesium biomaterials

Autores: Mojtaba Barzegari; Di Mei; Sviatlana V. Lamaka; Liesbet Geris; Liesbet Geris
Publicado en: Corrosion Science, Edición Volume 190, 2021, Página(s) 109674, ISSN 0010-938X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.corsci.2021.109674

Cracking the genetic code with neural networks

Autores: Marc Joiret; Marine Leclercq; Gaspard Lambrechts; Francesca Rapino; Pierre Close; Gilles Louppe; Liesbet Geris; Liesbet Geris; Liesbet Geris
Publicado en: Front Artificial Intelligence, 2023, ISSN 2624-8212
Editor: Frontiers Media
DOI: 10.3389/frai.2023.1128153

3D-Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo

Autores: Dorien Van hede; Bingbing Liang; Sandy Anania; Mojtaba Barzegari; Bruno Verlée; Grégory Nolens; Justine Pirson; Liesbet Geris; France Lambert
Publicado en: Advanced Functional Materials, 2022, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105002

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

Autores: Laura Lafuente-Gracia; Laura Lafuente-Gracia; Edoardo Borgiani; Edoardo Borgiani; Edoardo Borgiani; Gabriele Nasello; Gabriele Nasello; Gabriele Nasello; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 9, 2021, ISSN 2296-4185
Editor: Frontiers Media

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Autores: Mojtaba Barzegari; Liesbet Geris
Publicado en: Journal of Open Source Education,, Edición 4(40), 2021, Página(s) 89, ISSN 2577-3569
Editor: Open Journals
DOI: 10.21105/jose.00089

Highly scalable numerical simulation of coupled reaction-diffusion systems with moving interfaces

Autores: Barzegari, Mojtaba; Geris, Liesbet
Publicado en: The International Journal of High Performance Computing Applications, Edición 2022;36(2), 2022, Página(s) 198-213, ISSN 1094-3420
Editor: SAGE Publications
DOI: 10.1177/10943420211045939

Ribosome exit tunnel electrostatics

Autores: Joiret, Marc; Kerff, Frederic; Rapino, Francesca; Close, Pierre; Geris, Liesbet
Publicado en: Phys Rev E., 2022, ISSN 2470-0045
Editor: American Physical Society
DOI: 10.1103/physreve.105.014409

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autores: Flora T. Musuamba; Ine Skottheim Rusten; Raphaëlle Lesage; Giulia Russo; Roberta Bursi; Luca Emili; Gaby Wangorsch; Efthymios Manolis; Kristin E. Karlsson; Alexander Kulesza; Eulalie Courcelles; Jean-Pierre Boissel; Cécile F. Rousseau; Emmanuelle M. Voisin; Rossana Alessandrello; Nuno Curado; Enrico Dall'Ara; Blanca Rodriguez; Francesco Pappalardo; Liesbet Geris; Liesbet Geris
Publicado en: CPT Pharmacometrics Syst Pharmacol, Edición 24, 2021, ISSN 2163-8306
Editor: Nature Publishing Group
DOI: 10.1002/psp4.12669

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

Autores: Lionel Gillot; Agnes Noel; liesbet geris; Marc Joiret
Publicado en: Cancer Letters, Edición Volume 497, 2021, Página(s) Pages 154-164, ISSN 0304-3835
Editor: Elsevier BV
DOI: 10.1016/j.canlet.2020.10.020

Use of Computational Modeling to Study Joint Degeneration: A Review

Autores: Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers Bioengineering and biotechnology
DOI: 10.3389/fbioe.2020.00093

The Third Era of Tissue Engineering: Reversing the Innovation Drivers

Autores: Liesbet Geris, Ioannis Papantoniou
Publicado en: Tissue Engineering Part A, Edición 25/11-12, 2019, Página(s) 821-826, ISSN 1937-3341
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0064

In silico tools predict effects of drugs on bone remodelling

Autores: Liesbet Geris
Publicado en: Nature Reviews Rheumatology, 2020, ISSN 1759-4790
Editor: Nature Publishing Group
DOI: 10.1038/s41584-020-0457-6

Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

Autores: Sébastien Bournonville, Toon Lambrechts, Johan Vanhulst, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Publicado en: Biotechnology Journal, Edición 14/7, 2019, Página(s) 1800545, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800545

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Autores: Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2020.00376

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

Autores: Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou
Publicado en: Advanced Science, Edición 7/2, 2019, Página(s) 1902295, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.201902295

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning

Autores: Mohammad Mehrian, Toon Lambrechts, Marina Marechal, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Publicado en: Cytotherapy, Edición 22/2, 2020, Página(s) 82-90, ISSN 1465-3249
Editor: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.12.006

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Autores: Mohammad Mehrian, Liesbet Geris
Publicado en: Computer Methods in Biomechanics and Biomedical Engineering, Edición 23/7, 2020, Página(s) 285-294, ISSN 1025-5842
Editor: Taylor & Francis
DOI: 10.1080/10255842.2020.1719081

A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome

Autores: Marc Joiret; Francesca Rapino; Pierre Close; Liesbet Geris
Publicado en: Computational and Structural Biotechnology Journal, 2023, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1101/2022.03.07.483325

An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

Autores: Sakshi Khurana; Stefano Schivo; Stefano Schivo; Jacqueline R. M. Plass; Nikolas Mersinis; Jetse Scholma; Johan Kerkhofs; Leilei Zhong; Jaco van de Pol; Jaco van de Pol; Rom Langerak; Liesbet Geris; Marcel Karperien; Janine N. Post
Publicado en: Frontiers Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Editor: Frontiers Media
DOI: 10.3389/fbioe.2021.732917

In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies

Autores: Sophie Bekisz,Louis Baudin, Florence Buntinx, Agnès Noëlv, Liesbet Geris
Publicado en: Cancers, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061525

Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing.

Autores: Gabriella Nilsson Hall; Iene Rutten; Jeroen Lammertyn; Jens Eberhardt; Liesbet Geris; Liesbet Geris; Frank P. Luyten; Ioannis Papantoniou; Ioannis Papantoniou
Publicado en: Biofabrication, Edición 13(4), 2021, Página(s) 045025, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/ac2208

BioDeg: A finite element software for the simulation of the corrosion and biodegradation process in metallic biomaterials

Autores: Mojtaba Barzegari; Liesbet Geris
Publicado en: Journal of Open Source Software, Edición 7(74), 2022, Página(s) 4281, ISSN 2475-9066
Editor: Open Journals
DOI: 10.21105/joss.04281

The development of a 3D printable chitosan-based copolymer with tunable properties for dentoalveolar regeneration.

Autores: Mehdi Salar Amoli, Resmi Anand, Mostafa EzEldeen, Paulo Amorim, Liesbet Geris, Reinhilde Jacobs, Veerle Bloemen
Publicado en: Carbohydrate Polymers, 2022, ISSN 0144-8617
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2022.119441

Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels

Autores: Esther Reina-Romo; Sourav Mandal; Paulo Amorim; Paulo Amorim; Veerle Bloemen; Veerle Bloemen; Eleonora Ferraris; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 9, 2021, ISSN 2296-4185
Editor: Frontiers Media
DOI: 10.3389/fbioe.2021.701778

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Autores: Perez Boerema, Fernando Adrian; Barzegari Shankil, Mojtaba; Geris, Liesbet
Publicado en: Virtual and Physical Prototyping, Edición Vol 17, Iss 3, 2022, Página(s) 682-699, ISSN 1745-2759
Editor: Taylor & Francis
DOI: 10.6084/m9.figshare.19387475

Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

Autores: Sophie Bekisz, Liesbet Geris
Publicado en: Journal of Computational Science, 2020, ISSN 1877-7503
Editor: Elsevier BV
DOI: 10.1016/j.jocs.2020.101198

Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids

Autores: Hall, Gabriella Nilsson; Chandrakar, Amit; Pastore, Angela; Ioannidis, Konstantinos; Moisley, Katrina; Cirstea, Matei; Geris, Liesbet; Moroni, Lorenzo; Luyten, Frank P.; Wieringa, Paul; Papantoniou, Ioannis
Publicado en: Acta Biomaterialia, Edición Vol. 165, 2023, Página(s) pp. 111 - 124, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.037

An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation

Autores: Ehsan Sadeghian Dehkord; Greet Kerckhofs; Philippe Compère; France Lambert; Liesbet Geris
Publicado en: Journal of Functional Biomaterials, Edición Vol. 14, no.7, 2023, Página(s) p. 388, ISSN 2079-4983
Editor: Basel MDPI AG
DOI: 10.3390/jfb14070388