Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering

Informazioni relative al progetto

INSITE

ID dell’accordo di sovvenzione: 772418

DOI

10.3030/772418

Progetto chiuso

Data della firma CE 28 Maggio 2018

Data di avvio 1 Settembre 2018

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 161 750,00

Contributo UE

€ 2 161 750,00

Coordinato da

UNIVERSITE DE LIEGE
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (31)

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Autori: Raphaëlle Lesage; Mauricio N. Ferrao Blanco; Roberto Narcisi; Tim Welting; Gerjo J. V. M. van Osch; Liesbet Geris
Pubblicato in: Bmc Biology, Numero 20(1), 2022, Pagina/e 253, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-022-01451-8

Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering

Autori: Mehdi Salar Amoli; Resmi Anand; Mostafa EzEldeen; Liesbet Geris; Reinhilde Jacobs; Veerle Bloemen
Pubblicato in: Gels, Numero 10(2), 2024, ISSN 2310-2861
Editore: MDPI AG
DOI: 10.3390/gels10020140

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

Autori: Bingbing Liang; Ehsan Sadeghian Dehkord; Dorien Van Hede; Mojtaba Barzegari; Bruno Verlée; Justine Pirson; Grégory Nolens; France Lambert; Liesbet Geris
Pubblicato in: Journal of Functional Biomaterials, Numero Vol 14, Iss 12, 2023, Pagina/e p 563, ISSN 2079-4983
Editore: Basel MDPI AG
DOI: 10.3390/jfb14120563

Computational modeling of degradation process of biodegradable magnesium biomaterials

Autori: Mojtaba Barzegari; Di Mei; Sviatlana V. Lamaka; Liesbet Geris; Liesbet Geris
Pubblicato in: Corrosion Science, Numero Volume 190, 2021, Pagina/e 109674, ISSN 0010-938X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.corsci.2021.109674

Cracking the genetic code with neural networks

Autori: Marc Joiret; Marine Leclercq; Gaspard Lambrechts; Francesca Rapino; Pierre Close; Gilles Louppe; Liesbet Geris; Liesbet Geris; Liesbet Geris
Pubblicato in: Front Artificial Intelligence, 2023, ISSN 2624-8212
Editore: Frontiers Media
DOI: 10.3389/frai.2023.1128153

3D-Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo

Autori: Dorien Van hede; Bingbing Liang; Sandy Anania; Mojtaba Barzegari; Bruno Verlée; Grégory Nolens; Justine Pirson; Liesbet Geris; France Lambert
Pubblicato in: Advanced Functional Materials, 2022, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105002

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

Autori: Laura Lafuente-Gracia; Laura Lafuente-Gracia; Edoardo Borgiani; Edoardo Borgiani; Edoardo Borgiani; Gabriele Nasello; Gabriele Nasello; Gabriele Nasello; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 9, 2021, ISSN 2296-4185
Editore: Frontiers Media

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Autori: Mojtaba Barzegari; Liesbet Geris
Pubblicato in: Journal of Open Source Education,, Numero 4(40), 2021, Pagina/e 89, ISSN 2577-3569
Editore: Open Journals
DOI: 10.21105/jose.00089

Highly scalable numerical simulation of coupled reaction-diffusion systems with moving interfaces

Autori: Barzegari, Mojtaba; Geris, Liesbet
Pubblicato in: The International Journal of High Performance Computing Applications, Numero 2022;36(2), 2022, Pagina/e 198-213, ISSN 1094-3420
Editore: SAGE Publications
DOI: 10.1177/10943420211045939

Ribosome exit tunnel electrostatics

Autori: Joiret, Marc; Kerff, Frederic; Rapino, Francesca; Close, Pierre; Geris, Liesbet
Pubblicato in: Phys Rev E., 2022, ISSN 2470-0045
Editore: American Physical Society
DOI: 10.1103/physreve.105.014409

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autori: Flora T. Musuamba; Ine Skottheim Rusten; Raphaëlle Lesage; Giulia Russo; Roberta Bursi; Luca Emili; Gaby Wangorsch; Efthymios Manolis; Kristin E. Karlsson; Alexander Kulesza; Eulalie Courcelles; Jean-Pierre Boissel; Cécile F. Rousseau; Emmanuelle M. Voisin; Rossana Alessandrello; Nuno Curado; Enrico Dall'Ara; Blanca Rodriguez; Francesco Pappalardo; Liesbet Geris; Liesbet Geris
Pubblicato in: CPT Pharmacometrics Syst Pharmacol, Numero 24, 2021, ISSN 2163-8306
Editore: Nature Publishing Group
DOI: 10.1002/psp4.12669

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

Autori: Lionel Gillot; Agnes Noel; liesbet geris; Marc Joiret
Pubblicato in: Cancer Letters, Numero Volume 497, 2021, Pagina/e Pages 154-164, ISSN 0304-3835
Editore: Elsevier BV
DOI: 10.1016/j.canlet.2020.10.020

Use of Computational Modeling to Study Joint Degeneration: A Review

Autori: Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers Bioengineering and biotechnology
DOI: 10.3389/fbioe.2020.00093

The Third Era of Tissue Engineering: Reversing the Innovation Drivers

Autori: Liesbet Geris, Ioannis Papantoniou
Pubblicato in: Tissue Engineering Part A, Numero 25/11-12, 2019, Pagina/e 821-826, ISSN 1937-3341
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0064

In silico tools predict effects of drugs on bone remodelling

Autori: Liesbet Geris
Pubblicato in: Nature Reviews Rheumatology, 2020, ISSN 1759-4790
Editore: Nature Publishing Group
DOI: 10.1038/s41584-020-0457-6

Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

Autori: Sébastien Bournonville, Toon Lambrechts, Johan Vanhulst, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Pubblicato in: Biotechnology Journal, Numero 14/7, 2019, Pagina/e 1800545, ISSN 1860-6768
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800545

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Autori: Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2020.00376

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

Autori: Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou
Pubblicato in: Advanced Science, Numero 7/2, 2019, Pagina/e 1902295, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.201902295

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning

Autori: Mohammad Mehrian, Toon Lambrechts, Marina Marechal, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Pubblicato in: Cytotherapy, Numero 22/2, 2020, Pagina/e 82-90, ISSN 1465-3249
Editore: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.12.006

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Autori: Mohammad Mehrian, Liesbet Geris
Pubblicato in: Computer Methods in Biomechanics and Biomedical Engineering, Numero 23/7, 2020, Pagina/e 285-294, ISSN 1025-5842
Editore: Taylor & Francis
DOI: 10.1080/10255842.2020.1719081

A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome

Autori: Marc Joiret; Francesca Rapino; Pierre Close; Liesbet Geris
Pubblicato in: Computational and Structural Biotechnology Journal, 2023, ISSN 2001-0370
Editore: Elsevier BV
DOI: 10.1101/2022.03.07.483325

An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

Autori: Sakshi Khurana; Stefano Schivo; Stefano Schivo; Jacqueline R. M. Plass; Nikolas Mersinis; Jetse Scholma; Johan Kerkhofs; Leilei Zhong; Jaco van de Pol; Jaco van de Pol; Rom Langerak; Liesbet Geris; Marcel Karperien; Janine N. Post
Pubblicato in: Frontiers Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Editore: Frontiers Media
DOI: 10.3389/fbioe.2021.732917

In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies

Autori: Sophie Bekisz,Louis Baudin, Florence Buntinx, Agnès Noëlv, Liesbet Geris
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061525

Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing.

Autori: Gabriella Nilsson Hall; Iene Rutten; Jeroen Lammertyn; Jens Eberhardt; Liesbet Geris; Liesbet Geris; Frank P. Luyten; Ioannis Papantoniou; Ioannis Papantoniou
Pubblicato in: Biofabrication, Numero 13(4), 2021, Pagina/e 045025, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ac2208

BioDeg: A finite element software for the simulation of the corrosion and biodegradation process in metallic biomaterials

Autori: Mojtaba Barzegari; Liesbet Geris
Pubblicato in: Journal of Open Source Software, Numero 7(74), 2022, Pagina/e 4281, ISSN 2475-9066
Editore: Open Journals
DOI: 10.21105/joss.04281

The development of a 3D printable chitosan-based copolymer with tunable properties for dentoalveolar regeneration.

Autori: Mehdi Salar Amoli, Resmi Anand, Mostafa EzEldeen, Paulo Amorim, Liesbet Geris, Reinhilde Jacobs, Veerle Bloemen
Pubblicato in: Carbohydrate Polymers, 2022, ISSN 0144-8617
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2022.119441

Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels

Autori: Esther Reina-Romo; Sourav Mandal; Paulo Amorim; Paulo Amorim; Veerle Bloemen; Veerle Bloemen; Eleonora Ferraris; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 9, 2021, ISSN 2296-4185
Editore: Frontiers Media
DOI: 10.3389/fbioe.2021.701778

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Autori: Perez Boerema, Fernando Adrian; Barzegari Shankil, Mojtaba; Geris, Liesbet
Pubblicato in: Virtual and Physical Prototyping, Numero Vol 17, Iss 3, 2022, Pagina/e 682-699, ISSN 1745-2759
Editore: Taylor & Francis
DOI: 10.6084/m9.figshare.19387475

Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

Autori: Sophie Bekisz, Liesbet Geris
Pubblicato in: Journal of Computational Science, 2020, ISSN 1877-7503
Editore: Elsevier BV
DOI: 10.1016/j.jocs.2020.101198

Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids

Autori: Hall, Gabriella Nilsson; Chandrakar, Amit; Pastore, Angela; Ioannidis, Konstantinos; Moisley, Katrina; Cirstea, Matei; Geris, Liesbet; Moroni, Lorenzo; Luyten, Frank P.; Wieringa, Paul; Papantoniou, Ioannis
Pubblicato in: Acta Biomaterialia, Numero Vol. 165, 2023, Pagina/e pp. 111 - 124, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.037

An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation

Autori: Ehsan Sadeghian Dehkord; Greet Kerckhofs; Philippe Compère; France Lambert; Liesbet Geris
Pubblicato in: Journal of Functional Biomaterials, Numero Vol. 14, no.7, 2023, Pagina/e p. 388, ISSN 2079-4983
Editore: Basel MDPI AG
DOI: 10.3390/jfb14070388