Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering

Publications

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Auteurs: Raphaëlle Lesage; Mauricio N. Ferrao Blanco; Roberto Narcisi; Tim Welting; Gerjo J. V. M. van Osch; Liesbet Geris
Publié dans: Bmc Biology, Numéro 20(1), 2022, Page(s) 253, ISSN 1741-7007
Éditeur: BioMed Central
DOI: 10.1186/s12915-022-01451-8

Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering

Auteurs: Mehdi Salar Amoli; Resmi Anand; Mostafa EzEldeen; Liesbet Geris; Reinhilde Jacobs; Veerle Bloemen
Publié dans: Gels, Numéro 10(2), 2024, ISSN 2310-2861
Éditeur: MDPI AG
DOI: 10.3390/gels10020140

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

Auteurs: Bingbing Liang; Ehsan Sadeghian Dehkord; Dorien Van Hede; Mojtaba Barzegari; Bruno Verlée; Justine Pirson; Grégory Nolens; France Lambert; Liesbet Geris
Publié dans: Journal of Functional Biomaterials, Numéro Vol 14, Iss 12, 2023, Page(s) p 563, ISSN 2079-4983
Éditeur: Basel MDPI AG
DOI: 10.3390/jfb14120563

Computational modeling of degradation process of biodegradable magnesium biomaterials

Auteurs: Mojtaba Barzegari; Di Mei; Sviatlana V. Lamaka; Liesbet Geris; Liesbet Geris
Publié dans: Corrosion Science, Numéro Volume 190, 2021, Page(s) 109674, ISSN 0010-938X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.corsci.2021.109674

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

Auteurs: Laura Lafuente-Gracia; Laura Lafuente-Gracia; Edoardo Borgiani; Edoardo Borgiani; Edoardo Borgiani; Gabriele Nasello; Gabriele Nasello; Gabriele Nasello; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 9, 2021, ISSN 2296-4185
Éditeur: Frontiers Media

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Auteurs: Mojtaba Barzegari; Liesbet Geris
Publié dans: Journal of Open Source Education,, Numéro 4(40), 2021, Page(s) 89, ISSN 2577-3569
Éditeur: Open Journals
DOI: 10.21105/jose.00089

Highly scalable numerical simulation of coupled reaction-diffusion systems with moving interfaces

Auteurs: Barzegari, Mojtaba; Geris, Liesbet
Publié dans: The International Journal of High Performance Computing Applications, Numéro 2022;36(2), 2022, Page(s) 198-213, ISSN 1094-3420
Éditeur: SAGE Publications
DOI: 10.1177/10943420211045939

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Auteurs: Flora T. Musuamba; Ine Skottheim Rusten; Raphaëlle Lesage; Giulia Russo; Roberta Bursi; Luca Emili; Gaby Wangorsch; Efthymios Manolis; Kristin E. Karlsson; Alexander Kulesza; Eulalie Courcelles; Jean-Pierre Boissel; Cécile F. Rousseau; Emmanuelle M. Voisin; Rossana Alessandrello; Nuno Curado; Enrico Dall'Ara; Blanca Rodriguez; Francesco Pappalardo; Liesbet Geris; Liesbet Geris
Publié dans: CPT Pharmacometrics Syst Pharmacol, Numéro 24, 2021, ISSN 2163-8306
Éditeur: Nature Publishing Group
DOI: 10.1002/psp4.12669

Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

Auteurs: Lionel Gillot; Agnes Noel; liesbet geris; Marc Joiret
Publié dans: Cancer Letters, Numéro Volume 497, 2021, Page(s) Pages 154-164, ISSN 0304-3835
Éditeur: Elsevier BV
DOI: 10.1016/j.canlet.2020.10.020

Use of Computational Modeling to Study Joint Degeneration: A Review

Auteurs: Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, ISSN 2296-4185
Éditeur: Frontiers Bioengineering and biotechnology
DOI: 10.3389/fbioe.2020.00093

The Third Era of Tissue Engineering: Reversing the Innovation Drivers

Auteurs: Liesbet Geris, Ioannis Papantoniou
Publié dans: Tissue Engineering Part A, Numéro 25/11-12, 2019, Page(s) 821-826, ISSN 1937-3341
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2019.0064

In silico tools predict effects of drugs on bone remodelling

Auteurs: Liesbet Geris
Publié dans: Nature Reviews Rheumatology, 2020, ISSN 1759-4790
Éditeur: Nature Publishing Group
DOI: 10.1038/s41584-020-0457-6

Towards Self‐Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture

Auteurs: Sébastien Bournonville, Toon Lambrechts, Johan Vanhulst, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Publié dans: Biotechnology Journal, Numéro 14/7, 2019, Page(s) 1800545, ISSN 1860-6768
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800545

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Auteurs: Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2020.00376

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

Auteurs: Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou
Publié dans: Advanced Science, Numéro 7/2, 2019, Page(s) 1902295, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.201902295

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning

Auteurs: Mohammad Mehrian, Toon Lambrechts, Marina Marechal, Frank P. Luyten, Ioannis Papantoniou, Liesbet Geris
Publié dans: Cytotherapy, Numéro 22/2, 2020, Page(s) 82-90, ISSN 1465-3249
Éditeur: Taylor & Francis
DOI: 10.1016/j.jcyt.2019.12.006

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Auteurs: Mohammad Mehrian, Liesbet Geris
Publié dans: Computer Methods in Biomechanics and Biomedical Engineering, Numéro 23/7, 2020, Page(s) 285-294, ISSN 1025-5842
Éditeur: Taylor & Francis
DOI: 10.1080/10255842.2020.1719081

Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing.

Auteurs: Gabriella Nilsson Hall; Iene Rutten; Jeroen Lammertyn; Jens Eberhardt; Liesbet Geris; Liesbet Geris; Frank P. Luyten; Ioannis Papantoniou; Ioannis Papantoniou
Publié dans: Biofabrication, Numéro 13(4), 2021, Page(s) 045025, ISSN 1758-5082
Éditeur: IOS Press
DOI: 10.1088/1758-5090/ac2208

BioDeg: A finite element software for the simulation of the corrosion and biodegradation process in metallic biomaterials

Auteurs: Mojtaba Barzegari; Liesbet Geris
Publié dans: Journal of Open Source Software, Numéro 7(74), 2022, Page(s) 4281, ISSN 2475-9066
Éditeur: Open Journals
DOI: 10.21105/joss.04281

Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels

Auteurs: Esther Reina-Romo; Sourav Mandal; Paulo Amorim; Paulo Amorim; Veerle Bloemen; Veerle Bloemen; Eleonora Ferraris; Liesbet Geris; Liesbet Geris; Liesbet Geris; Liesbet Geris
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 9, 2021, ISSN 2296-4185
Éditeur: Frontiers Media
DOI: 10.3389/fbioe.2021.701778

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Auteurs: Perez Boerema, Fernando Adrian; Barzegari Shankil, Mojtaba; Geris, Liesbet
Publié dans: Virtual and Physical Prototyping, Numéro Vol 17, Iss 3, 2022, Page(s) 682-699, ISSN 1745-2759
Éditeur: Taylor & Francis
DOI: 10.6084/m9.figshare.19387475

Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids

Auteurs: Hall, Gabriella Nilsson; Chandrakar, Amit; Pastore, Angela; Ioannidis, Konstantinos; Moisley, Katrina; Cirstea, Matei; Geris, Liesbet; Moroni, Lorenzo; Luyten, Frank P.; Wieringa, Paul; Papantoniou, Ioannis
Publié dans: Acta Biomaterialia, Numéro Vol. 165, 2023, Page(s) pp. 111 - 124, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.037

An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation

Auteurs: Ehsan Sadeghian Dehkord; Greet Kerckhofs; Philippe Compère; France Lambert; Liesbet Geris
Publié dans: Journal of Functional Biomaterials, Numéro Vol. 14, no.7, 2023, Page(s) p. 388, ISSN 2079-4983
Éditeur: Basel MDPI AG
DOI: 10.3390/jfb14070388

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