Periodic Reporting for period 1 - MEDIVAC (Machine learning software to design personalized neoantigen vaccines tailored to specific vaccine delivery systems)
Periodo di rendicontazione: 2017-06-01 al 2017-10-31
Cancer remains a leading cause of disease and death worldwide. An estimated 14m new cancer cases were diagnosed in 2012 and the annual cost of treating cancer in the EU is estimated to be over €150b. Thus, there is a clear need for more effective methods of treatment to reduce this global burden. Immunotherapy, and particularly personalized cancer vaccines represent an exciting new weapon in the war against cancer. However, to develop personalized cancer vaccines, it is necessary to identify personalized tumor-specific targets known as neoantigens in a cost effective and clinically actionable timeframe.
OncoImmunity is currently developing a state-of-the-art software solution that addresses this problem– the Immune Profiler prediction engine (PE) which leverages advanced machine-learning algorithms and bioinformatics approaches to predict whether a potential neoantigen has the correct physiochemical features to be immunogenic. However, to fully enable the development of personalized vaccines this software need to be customized to specific vaccine delivery systems (VDS) as different vaccine platforms induce responses against different repertoires of neoantigen. The tailored software will be called MEDIVAC.
OncoImmunity is currently developing a state-of-the-art software solution that addresses this problem– the Immune Profiler prediction engine (PE) which leverages advanced machine-learning algorithms and bioinformatics approaches to predict whether a potential neoantigen has the correct physiochemical features to be immunogenic. However, to fully enable the development of personalized vaccines this software need to be customized to specific vaccine delivery systems (VDS) as different vaccine platforms induce responses against different repertoires of neoantigen. The tailored software will be called MEDIVAC.
To develop MEDIVAC the core Immune Profiler machine learning (ML) framework needs to be adapted to enable the client to iteratively train the framework on their own clinically validated data to generate VDS specific predictions. In addition, the software must be able to optimize vaccine constructs to minimize off-target autoimmune responses. The work performed in this project assessed the feasibility of adapting the core Immune Profiler PE for this purpose. In addition, the project mapped out the pathway for combining these novel features in a validated and CE certified software package that will enable OncoImmunity to take a leading position in this rapidly growing market. The conclusion is that the development of the MEDIVAC software is feasible, and that the software can be developed, and CE marked as an in vitro medical device.
The core Immune Profiler machine learning framework which will be at the heart of the MEDIVAC software solution is already beyond the current state-of-the-art in terms of its predictive capability. The adaption of this framework to develop the MEDIVAC software promises to help revolutionize cancer treatment allowing the development of personalized cancer vaccines in a cost effective and clinically actionable timeframe.