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InSilc: In-silico trials for drug-eluting BVS design, development and evaluation

Objective

The aim of InSilc is to develop an in-silico clinical trial (ISCT) platform for designing, developing and assessing drug-eluting bioresorbable vascular scaffolds (BVS), by building on the comprehensive biological and biomedical knowledge and advanced modelling approaches to simulate their implantation performance in the individual cardiovascular physiology. The InSilc platform is based on the extension of existing multidisciplinary and multiscale models for simulating the drug-eluting BVS mechanical behaviour, the deployment and degradation, the fluid dynamics in the micro- and macroscale, and the myocardial perfusion, for predicting its interaction with the vascular wall in the short- and medium/long term. InSilc goes beyond the design and development of ISCT and lays on the generation of in-silico models for obtaining quick and informed answers to several “What if” scenarios. “Virtual” patients would be given a “virtual” drug-eluting BVS, for observing the performance of the scaffold, assess and quantify the intended effect, with a deeper understanding than normal trials can provide. By integrating the information obtained from different in-silico predictive models, InSilc will: (i) assist in the development, assessment and optimization of the drug-eluting BVS and deliver accurate and reliable information to the Stent Biomedical Industry, (ii) assist the interventional Cardiologists in improving the surgical process of drug-eluting BVS implantation, support them in the clinical assessment and reduce the complications of suboptimal scaffold performance. By introducing computer simulations for establishing the safety and efficacy of drug-eluting BVS, InSilc aims to lower development costs and shorten time-to-market, reduce, refine, and partially replace human clinical trials through a more effective human clinical trials design, reduce the need for animal testing and result in a significant reduction of the associated direct and indirect costs.

Call for proposal

H2020-SC1-2016-2017

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Sub call

H2020-SC1-2017-CNECT-2

Coordinator

IDRYMA TECHNOLOGIAS KAI EREVNAS
Net EU contribution
€ 822 365,60
Address
N Plastira Str 100
70013 Irakleio
Greece

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Region
Ηράκλειο Κρήτη Νησιά Αιγαίου
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (12)

THE UNIVERSITY OF SHEFFIELD

Participation ended

United Kingdom
Net EU contribution
€ 98 000,00
Address
Firth Court Western Bank
S10 2TN Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 805 580,40
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
POLITECNICO DI MILANO
Italy
Net EU contribution
€ 603 130,40
Address
Piazza Leonardo Da Vinci 32
20133 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 343 705,40
Address
Piazzale Aldo Moro 7
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MEDIOLANUM CARDIO RESEARCH SRL
Italy
Net EU contribution
€ 259 330,40
Address
Piazza Giovine Italia 5
20123 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FEOPS NV
Belgium
Net EU contribution
€ 409 330,40
Address
Technologiepark Zwijnaarde 122
9052 Gent

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
Net EU contribution
€ 566 155,40
Address
University Road
H91 Galway

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Serbia
Net EU contribution
€ 363 080,40
Address
Prvoslava Stojanovica Street 6
34000 Kragujevac

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Србија - југ Регион Шумадије и Западне Србије Шумадијска област
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PANEPISTIMIO IOANNINON
Greece
Net EU contribution
€ 200 605,40
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina

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Region
Ιωάννινα Ήπειρος Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CBSET, INC
United States
Net EU contribution
€ 503 211,65
Non-EU contribution
€ 0,00
BOSTON SCIENTIFIC LIMITED
Ireland
Net EU contribution
€ 305 580,40
Address
Ballybrit Business Park
H91 Galway

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Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 559 580,40
Address
Woodhouse Lane
LS2 9JT Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00