InSilc: In-silico trials for drug-eluting BVS design, development and evaluation

Deliverables

Documents, reports (7)

Dissemination plan and activities v2

Report summarising the dissemination strategy and activities of the InSilc 2nd year

Project website, poster, flyer and social media

Report presenting the InSilc website, poster, flyer and social media accounts

Quality Assurance plan

Report on the Quality Assurance plan

Dissemination plan and activities v3

Report summarising the dissemination strategy and activities of the InSilc 3rd year

Project handbook

Report on the project handbook

Final press release

Report of the InSilc final press release

Dissemination plan and activities v1

Report summarising the dissemination strategy and activities of the InSilc 1st year

Publications

Peer reviewed articles (15)

A Novel Approach to Generate a Virtual Population of Human Coronary Arteries for In Silico Clinical Trials of Stent Design

Author(s): Dimitrios Pleouras, Antonis Sakellarios, George Rigas, Georgia S. Karanasiou, Panagiota Tsompou, Gianna Karanasiou, Vassiliki Kigka, Savvas Kyriakidis, Vasileios Pezoulas, George Gois, Nikolaos Tachos, Aidonis Ramos, Gualtiero Pelosi, Silvia Rocchiccioli, Lampros Michalis, Dimitrios I. Fotiadis
Published in: IEEE Open Journal of Engineering in Medicine and Biology, 2, 2021, Page(s) 201-209, ISSN 2644-1276
Publisher: IEEE
DOI: 10.1109/ojemb.2021.3082328

From the real device to the digital twin: A coupled experimental-numerical strategy to investigate a novel bioresorbable vascular scaffold

Author(s): Luca Antonini, Francesca Berti, Benedetta Isella, Dipok Hossain, Lorenzo Mandelli, Giancarlo Pennati, Lorenza Petrini
Published in: PLOS ONE, 16/6, 2021, Page(s) e0252788, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0252788

Modulated molecular markers of restenosis and thrombosis by in-vitro vascular cells exposed to bioresorbable scaffolds

Author(s): F Vozzi, A Cecchettini, M Cabiati, Fornaro Mg, P Aretini, S Del Ry, S Rocchiccioli, G Pelosi
Published in: Biomedical Materials, 16/4, 2021, Page(s) 045039, ISSN 1748-6041
Publisher: Institute of Physics Publishing
DOI: 10.1088/1748-605x/ac0401

Non-Invasive Prediction of Site-Specific Coronary Atherosclerotic Plaque Progression using Lipidomics, Blood Flow, and LDL Transport Modeling

Author(s): Antonis I. Sakellarios, Panagiota Tsompou, Vassiliki Kigka, Panagiotis Siogkas, Savvas Kyriakidis, Nikolaos Tachos, Georgia Karanasiou, Arthur Scholte, Alberto Clemente, Danilo Neglia, Oberdan Parodi, Juhani Knuuti, Lampros K. Michalis, Gualtiero Pelosi, Silvia Rocchiccioli, Dimitrios I. Fotiadis
Published in: Applied Sciences, 11/5, 2021, Page(s) 1976, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11051976

Physical and mechanical degradation behaviour of semi-crystalline PLLA for bioresorbable stent applications

Author(s): Katarzyna Polak-Kraśna, Ali Reza Abaei, Reyhaneh Neghabat Shirazi, Eoin Parle, Oliver Carroll, William Ronan, Ted J. Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 118, 2021, Page(s) 104409, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2021.104409

In vitro and in silico testing of partially and fully bioresorbable vascular scaffold

Author(s): Nenad Filipovic, Dalibor Nikolic, Velibor Isailovic, Miljan Milosevic, Vladimir Geroski, Georgia Karanasiou, Martin Fawdry, Aiden Flanagan, Dimitrios Fotiadis, Milos Kojic
Published in: Journal of Biomechanics, 115, 2021, Page(s) 110158, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110158

Multimodal Loading Environment Predicts Bioresorbable Vascular Scaffolds’ Durability

Author(s): Pei-Jiang Wang, Francesca Berti, Luca Antonini, Farhad Rikhtegar Nezami, Lorenza Petrini, Francesco Migliavacca, Elazer R. Edelman
Published in: Annals of Biomedical Engineering, 49/5, 2021, Page(s) 1298-1307, ISSN 0090-6964
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02673-z

Population‐specific modelling of between/within‐subject flow variability in the carotid arteries of the elderly

Author(s): Toni Lassila, Ali Sarrami‐Foroushani, SeyedMostafa Hejazi, Alejandro F. Frangi
Published in: International Journal for Numerical Methods in Biomedical Engineering, 36/1, 2020, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3271

Is modeling stents still an important issue?

Author(s): Francesco Migliavacca
Published in: Procedia Structural Integrity, 15, 2019, Page(s) 46-50, ISSN 2452-3216
Publisher: ELSEVIER
DOI: 10.1016/j.prostr.2019.07.009

A computational model for prediction of clot platelet content in flow-diverted intracranial aneurysms

Author(s): Sarrami-Foroushani, Ali; Lassila, Toni; Hejazi, Seyed Mostafa; Nagaraja, Sanjoy; Bacon, Andrew; Frangi, Alejandro F.
Published in: Journal of Biomechanics, 2019, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.5281/zenodo.2671637

Three-dimensional reconstruction and NURBS-based structured meshing of coronary arteries from the conventional X-ray angiography projection images

Author(s): Arso M. Vukicevic, Serkan Çimen, Nikola Jagic, Gordana Jovicic, Alejandro F. Frangi, Nenad Filipovic
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-19440-9

Impact of bioresorbable scaffold design characteristics on local haemodynamic forces: an ex vivo assessment with computational fluid dynamics simulations

Author(s): Imane Tarrahi, Monika Colombo, Eline M.J. Hartman, Maria Natalia Tovar Forero, Ryo Torii, Claudio Chiastra, Joost Daemen, Frank J.H. Gijsen
Published in: EuroIntervention, 16/11, 2020, Page(s) e930-e937, ISSN 1969-6213
Publisher: EuroIntervention
DOI: 10.4244/eij-d-19-00657

Non-intrusive and semi-intrusive uncertainty quantification of a multiscale in-stent restenosis model

Author(s): Dongwei Ye, Anna Nikishova, Lourens Veen, Pavel Zun, Alfons G. Hoekstra
Published in: Reliability Engineering & System Safety, 214, 2021, Page(s) 107734, ISSN 0951-8320
Publisher: Elsevier BV
DOI: 10.1016/j.ress.2021.107734

Effects of local coronary blood flow dynamics on the predictions of a model of in-stent restenosis

Author(s): Pavel Zun, Andrey Svitenkov, Alfons Hoekstra
Published in: Journal of Biomechanics, 120, 2021, Page(s) 110361, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110361

An algorithm for finding and adding boundary conditions with the aim of solving the contact problem in computational mechanics

Author(s): Velibor Isailovic, Nenad Filipovic
Published in: Simulation Modelling Practice and Theory, 108, 2021, Page(s) 102247, ISSN 1569-190X
Publisher: Elsevier BV
DOI: 10.1016/j.simpat.2020.102247

Conference proceedings (7)

High Throughput Computation of Reference Ranges of Biventricular Cardiac Function on the UK Biobank Population Cohort

Author(s): Rahman Attar, Marco Pereañez, Ali Gooya, Xènia Albà, Le Zhang, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Published in: Statistical Atlases and Computational Models of the Heart. Atrial Segmentation and LV Quantification Challenges - 9th International Workshop, STACOM 2018, Held in Conjunction with MICCAI 2018, Granada, Spain, September 16, 2018, Revised Selected Papers, 11395, 2019, Page(s) 114-121, ISBN 978-3-030-12028-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-12029-0_13

InSilc: 3D Reconstruction and plaque characterization tool

Author(s): GEORGIA KARANASIOU; GEORGE RIGAS; SAVVAS KYRIAKIDIS; NIKOLAOS TACHOS; ANTONIS SAKELLARIOS; DIMITRIOS FOTIADIS
Published in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018
Publisher: IEEE
DOI: 10.5281/zenodo.2017989

In Silico analysis of stent deployment - effect of stent design

Author(s): Georgia S. Karanasiou; Nikolaos S. Tachos; Antonios Sakellarios; Claire Conway; Giancarlo Pennati; Lorenza Petrini; Lampros K. Michalis; Elazer R. Edelman; Dimitrios I. Fotiadis
Published in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018
Publisher: IEEE
DOI: 10.5281/zenodo.2018351

High Throughput Computation of Reference Ranges of Biventricular Cardiac Function on the UK Biobank Population Cohort

Author(s): Attar, Rahman; Pereanez, Marco; Gooya, Ali; Alba, Xenia; Zhang, Le; Piechnik, Stefan K.; Neubauer, Stefan; Petersen, Steffen E.; Frangi, Alejandro F.
Published in: Lecture Notes in Computer Science. MICCAI Medical Image Computing and Computer Assisted Interventions, volume 11395, 2018, Page(s) 114-121, ISBN 9783-030120283
Publisher: Springer Verlag

Atherosclerotic Plaque Growth Prediction in Coronary Arteries using a Computational Multi-level Model: The Effect of Diabetes

Author(s): Dimitris Pleouras; Antonis I. Sakellarios; Georgia S. Karanasiou; Savvas Kyriakidis; Panagiota Tsompou; Vassiliki I. Kigka; Dimitrios I. Fotiadis
Published in: IEEE BIBE 2019, 2, 2019
Publisher: IEEE
DOI: 10.5281/zenodo.3538010

A Novel Methodology for Detection of Lumen, Outer Wall, Plaques and Stent Struts in Coronary Arteries Using Optical Coherence Tomography

Author(s): Savvas Kyriakidis, Antonis Sakellarios, Georgia Karanasiou, Dimitrios I. Fotiadis
Published in: 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 2019, Page(s) 697-701, ISBN 978-1-7281-4617-1
Publisher: IEEE
DOI: 10.1109/bibe.2019.00131

InSilc: a cloud platform for in silico clinical trials for bioresorbable vascular scaffolds

Author(s): Karanasiou, G.; Rigas, G.; Tachos, T.; Fotiadis, D.
Published in: 41st International Engineering in Medicine and Biology Conference (EMBC 2019), 5, 2019
Publisher: EMBC
DOI: 10.5281/zenodo.3537991