InSilc: In-silico trials for drug-eluting BVS design, development and evaluation

Informations projet

InSilc

N° de convention de subvention: 777119

DOI

10.3030/777119

Projet clôturé

Date de signature de la CE 16 Octobre 2017

Date de début 1 Novembre 2017

Date de fin 30 Avril 2021

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 839 656,25

Contribution de l’UE

€ 5 839 656,25

Coordonné par

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Dissemination plan and activities v2

Report summarising the dissemination strategy and activities of the InSilc 2nd year

Project website, poster, flyer and social media

Report presenting the InSilc website, poster, flyer and social media accounts

Quality Assurance plan

Report on the Quality Assurance plan

Dissemination plan and activities v3

Report summarising the dissemination strategy and activities of the InSilc 3rd year

Project handbook

Report on the project handbook

Final press release

Report of the InSilc final press release

Dissemination plan and activities v1

Report summarising the dissemination strategy and activities of the InSilc 1st year

Publications

Peer reviewed articles (16)

A Novel Approach to Generate a Virtual Population of Human Coronary Arteries for In Silico Clinical Trials of Stent Design

Auteurs: Dimitrios Pleouras, Antonis Sakellarios, George Rigas, Georgia S. Karanasiou, Panagiota Tsompou, Gianna Karanasiou, Vassiliki Kigka, Savvas Kyriakidis, Vasileios Pezoulas, George Gois, Nikolaos Tachos, Aidonis Ramos, Gualtiero Pelosi, Silvia Rocchiccioli, Lampros Michalis, Dimitrios I. Fotiadis
Publié dans: IEEE Open Journal of Engineering in Medicine and Biology, Numéro 2, 2021, Page(s) 201-209, ISSN 2644-1276
Éditeur: IEEE
DOI: 10.1109/ojemb.2021.3082328

From the real device to the digital twin: A coupled experimental-numerical strategy to investigate a novel bioresorbable vascular scaffold

Auteurs: Luca Antonini, Francesca Berti, Benedetta Isella, Dipok Hossain, Lorenzo Mandelli, Giancarlo Pennati, Lorenza Petrini
Publié dans: PLOS ONE, Numéro 16/6, 2021, Page(s) e0252788, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0252788

Modulated molecular markers of restenosis and thrombosis by in-vitro vascular cells exposed to bioresorbable scaffolds

Auteurs: F Vozzi, A Cecchettini, M Cabiati, Fornaro Mg, P Aretini, S Del Ry, S Rocchiccioli, G Pelosi
Publié dans: Biomedical Materials, Numéro 16/4, 2021, Page(s) 045039, ISSN 1748-6041
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1748-605x/ac0401

Non-Invasive Prediction of Site-Specific Coronary Atherosclerotic Plaque Progression using Lipidomics, Blood Flow, and LDL Transport Modeling

Auteurs: Antonis I. Sakellarios, Panagiota Tsompou, Vassiliki Kigka, Panagiotis Siogkas, Savvas Kyriakidis, Nikolaos Tachos, Georgia Karanasiou, Arthur Scholte, Alberto Clemente, Danilo Neglia, Oberdan Parodi, Juhani Knuuti, Lampros K. Michalis, Gualtiero Pelosi, Silvia Rocchiccioli, Dimitrios I. Fotiadis
Publié dans: Applied Sciences, Numéro 11/5, 2021, Page(s) 1976, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app11051976

Physical and mechanical degradation behaviour of semi-crystalline PLLA for bioresorbable stent applications

Auteurs: Katarzyna Polak-Kraśna, Ali Reza Abaei, Reyhaneh Neghabat Shirazi, Eoin Parle, Oliver Carroll, William Ronan, Ted J. Vaughan
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, Numéro 118, 2021, Page(s) 104409, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.jmbbm.2021.104409

Validation of the computational model of a coronary DES delivery system: a fundamental step towards in-silico clinical trials

Auteurs: Antonini, Luca; Mandelli, Lorenzo; Berti, Francesca; Pennati, Giancarlo; Petrini, Lorenza
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, 2021, ISSN 1751-6161
Éditeur: Elsevier BV

In vitro and in silico testing of partially and fully bioresorbable vascular scaffold

Auteurs: Nenad Filipovic, Dalibor Nikolic, Velibor Isailovic, Miljan Milosevic, Vladimir Geroski, Georgia Karanasiou, Martin Fawdry, Aiden Flanagan, Dimitrios Fotiadis, Milos Kojic
Publié dans: Journal of Biomechanics, Numéro 115, 2021, Page(s) 110158, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2020.110158

Multimodal Loading Environment Predicts Bioresorbable Vascular Scaffolds’ Durability

Auteurs: Pei-Jiang Wang, Francesca Berti, Luca Antonini, Farhad Rikhtegar Nezami, Lorenza Petrini, Francesco Migliavacca, Elazer R. Edelman
Publié dans: Annals of Biomedical Engineering, Numéro 49/5, 2021, Page(s) 1298-1307, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02673-z

Population‐specific modelling of between/within‐subject flow variability in the carotid arteries of the elderly

Auteurs: Toni Lassila, Ali Sarrami‐Foroushani, SeyedMostafa Hejazi, Alejandro F. Frangi
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, Numéro 36/1, 2020, ISSN 2040-7939
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3271

Is modeling stents still an important issue?

Auteurs: Francesco Migliavacca
Publié dans: Procedia Structural Integrity, Numéro 15, 2019, Page(s) 46-50, ISSN 2452-3216
Éditeur: ELSEVIER
DOI: 10.1016/j.prostr.2019.07.009

A computational model for prediction of clot platelet content in flow-diverted intracranial aneurysms

Auteurs: Sarrami-Foroushani, Ali; Lassila, Toni; Hejazi, Seyed Mostafa; Nagaraja, Sanjoy; Bacon, Andrew; Frangi, Alejandro F.
Publié dans: Journal of Biomechanics, 2019, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.2671637

Three-dimensional reconstruction and NURBS-based structured meshing of coronary arteries from the conventional X-ray angiography projection images

Auteurs: Arso M. Vukicevic, Serkan Çimen, Nikola Jagic, Gordana Jovicic, Alejandro F. Frangi, Nenad Filipovic
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-19440-9

Impact of bioresorbable scaffold design characteristics on local haemodynamic forces: an ex vivo assessment with computational fluid dynamics simulations

Auteurs: Imane Tarrahi, Monika Colombo, Eline M.J. Hartman, Maria Natalia Tovar Forero, Ryo Torii, Claudio Chiastra, Joost Daemen, Frank J.H. Gijsen
Publié dans: EuroIntervention, Numéro 16/11, 2020, Page(s) e930-e937, ISSN 1969-6213
Éditeur: EuroIntervention
DOI: 10.4244/eij-d-19-00657

Non-intrusive and semi-intrusive uncertainty quantification of a multiscale in-stent restenosis model

Auteurs: Dongwei Ye, Anna Nikishova, Lourens Veen, Pavel Zun, Alfons G. Hoekstra
Publié dans: Reliability Engineering & System Safety, Numéro 214, 2021, Page(s) 107734, ISSN 0951-8320
Éditeur: Elsevier BV
DOI: 10.1016/j.ress.2021.107734

Effects of local coronary blood flow dynamics on the predictions of a model of in-stent restenosis

Auteurs: Pavel Zun, Andrey Svitenkov, Alfons Hoekstra
Publié dans: Journal of Biomechanics, Numéro 120, 2021, Page(s) 110361, ISSN 0021-9290
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110361

An algorithm for finding and adding boundary conditions with the aim of solving the contact problem in computational mechanics

Auteurs: Velibor Isailovic, Nenad Filipovic
Publié dans: Simulation Modelling Practice and Theory, Numéro 108, 2021, Page(s) 102247, ISSN 1569-190X
Éditeur: Elsevier BV
DOI: 10.1016/j.simpat.2020.102247

Conference proceedings (6)

High Throughput Computation of Reference Ranges of Biventricular Cardiac Function on the UK Biobank Population Cohort

Auteurs: Rahman Attar, Marco Pereañez, Ali Gooya, Xènia Albà, Le Zhang, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Publié dans: Statistical Atlases and Computational Models of the Heart. Atrial Segmentation and LV Quantification Challenges - 9th International Workshop, STACOM 2018, Held in Conjunction with MICCAI 2018, Granada, Spain, September 16, 2018, Revised Selected Papers, Numéro 11395, 2019, Page(s) 114-121, ISBN 978-3-030-12028-3
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-12029-0_13

InSilc: 3D Reconstruction and plaque characterization tool

Auteurs: GEORGIA KARANASIOU; GEORGE RIGAS; SAVVAS KYRIAKIDIS; NIKOLAOS TACHOS; ANTONIS SAKELLARIOS; DIMITRIOS FOTIADIS
Publié dans: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018
Éditeur: IEEE
DOI: 10.5281/zenodo.2017989

In Silico analysis of stent deployment - effect of stent design

Auteurs: Georgia S. Karanasiou; Nikolaos S. Tachos; Antonios Sakellarios; Claire Conway; Giancarlo Pennati; Lorenza Petrini; Lampros K. Michalis; Elazer R. Edelman; Dimitrios I. Fotiadis
Publié dans: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018
Éditeur: IEEE
DOI: 10.5281/zenodo.2018351

Atherosclerotic Plaque Growth Prediction in Coronary Arteries using a Computational Multi-level Model: The Effect of Diabetes

Auteurs: Dimitris Pleouras; Antonis I. Sakellarios; Georgia S. Karanasiou; Savvas Kyriakidis; Panagiota Tsompou; Vassiliki I. Kigka; Dimitrios I. Fotiadis
Publié dans: IEEE BIBE 2019, Numéro 2, 2019
Éditeur: IEEE
DOI: 10.5281/zenodo.3538010

A Novel Methodology for Detection of Lumen, Outer Wall, Plaques and Stent Struts in Coronary Arteries Using Optical Coherence Tomography

Auteurs: Savvas Kyriakidis, Antonis Sakellarios, Georgia Karanasiou, Dimitrios I. Fotiadis
Publié dans: 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 2019, Page(s) 697-701, ISBN 978-1-7281-4617-1
Éditeur: IEEE
DOI: 10.1109/bibe.2019.00131

InSilc: a cloud platform for in silico clinical trials for bioresorbable vascular scaffolds

Auteurs: Karanasiou, G.; Rigas, G.; Tachos, T.; Fotiadis, D.
Publié dans: 41st International Engineering in Medicine and Biology Conference (EMBC 2019), Numéro 5, 2019
Éditeur: EMBC
DOI: 10.5281/zenodo.3537991