Risultati finali
The process of technology and knowledge transfer will be supported by the appropriate focused training of partners. This will be achieved through the organization of 2 training seminars. In order to ensure the wide-scale uptake of knowledge and technology generated within the sector, the partners involved will structure dedicated training programs for the internal staff. In addition, the efficient transfer of knowledge and expertise from the RTD partners to the rest of the Consortium will also be planned and executed.
OACTIVE dissemination workshopA dedicated workshop will be organised to present the OACTIVE technologies. Representatives will be invited from interested local authorities, key scientists, as well as policy makers within Europe, targeting as many Member States as possible, but also including some representatives from outside Europe. The event will also be open to the interested public.
Computational intelligence models developmentThis deliverable will contain a detailed documentation of the machine learning and deep learning infrastructure that will be developed in OACTIVE.
OACTIVE final conferenceA final conference will be organised presenting the main outputs and findings and methodological advances of the project. The event will include thematic breakout sessions, panel discussions, and networking events to build strong partnerships
OACTIVE Web Site and media presenceThis deliverable will include: i) The project website including a public section and a secure section, which will be accessible only by project partners and the Commission; ii) The OACTIVE brochure (including objectives, concept and profiles of partners); iii) Presence on popular social networks.
OACTIVE videosTwo promotional videos (One teaser and one final) will be produced also. One video will be produced at M3 of the project where the OACTIVE objectives will be described and one at M36 presenting the project’s achievements
Ontology-based framework for data standardisationThis deliverable presents the employed ontology-based mechanisms for data standardisation
OA in vitro modelsThis deliverable will identify the most faithful in vitro model of OA-like changes between trauma-induced OA and inflammatory cytokines signalling. Furthermore, it will validate the use of engineered constructs for in vitro high throughput analysis of OA severity and progression in relation to local cellular responses.
Design and implementation of personalised predictive modelsThis deliverable will present the working prototypes of the personalised predictive OACTIVE models used either for prevention, diagnosis or even during the intervention stage.
This document will contain the studies made on the different devices, architectures, and software platforms available for the project's game system. It will identify the devices taking part in the OACTIVE game architecture and also the graphics engines to be used for games development.
Effects of hormones during OAThis deliverable will assess whether cycling hormones have a protective effect against OA and will provide cellular response profiles to the presence/absence of hormones.
First version of Ethics and Safety ManualThis report will define the first version of ethical and safety management issues.
Evaluation Toolbox DocumentationThis deliverable describes the evaluation rationale, roadmap, methods and processes that will be used for the evaluation and the validation of the OACTIVE system.
Documentation on the qualification of biomarkers found in serum of OA patientsThis deliverable will contain a detailed documentation and qualification of three Prognostic Biomarkers of Bone and Cartilage Degradation and Synthesis and 3 Inflammatory Biomarkers and their concentrations in serum samples from OA patients.
Data Collection protocolThis report will describe in detail the data collection and evaluation protocol that will be followed in WP6.
Best practices handbookA handbook presenting lessons learnt and best practices learnt during the project will be developed and given to public, targeting to the long term contribution on to the formation of common policies on OA treatment in EU level.
Documentation of social attributes and interdependencies of cognitive and social determinantsThis deliverable will contain a detailed documentation of the social attributes and the description of the complex interdependencies and interactions between the different social factor families (social position, social context, psychological influences, personal factors).
Markers and cellular responses in OA osteochondral unitsThis deliverable will associate in vitro analysis with in vivo assessments on the basis of matching imaging and biomarkers results. Furthermore, this deliverable will provide a dataset including cartilage and bone soluble markers, microCT imaging of bone and cartilage, cellular response by qRT-PCR, histology and immunohistochemistry that will be used for the generation of the multiscale hypermodel.
Evaluation of OACTIVE in big data registriesThis deliverable describes the results and outcomes of the long term evaluation of OACTIVE using data from big data registries.
User Behaviour Modelling DocumentationThis deliverable will contain a detailed documentation of the datasets and the analyses of the user behaviour based on the sensor outputs from the different services
Documentation of behavioural attributes and interdependencies of physical factorsThis deliverable will contain a detailed documentation of the behavioural attributes and the description of the complex interdependencies and interactions between them.
Data Management InfrastructureThis report will describe the cloud-based infrastructure that will be setup for the project and its functionalities.
User requirements analysis reportThis deliverable will pro-vide a reference set of user requirements. It should constitute a reference guide for the development of different functions of OACTIVE. One chapter of this report will be dedicated to the analysis of the state-of-the-art technology.
Report on qualification of OA-related exosomal and microbiome biomarkersThis deliverable will contain a detailed documentation and qualification of exosomal biomarkers isolated from fluid samples of OA patients.
Evaluation of OACTIVE in human populationThis deliverable describes the evaluation results and outcomes of the clinical studies.
Final version of Ethics and Safety ManualThis report will define the final version of ethical and safety management issues.
Data management plan StrategyThis deliverable will determine the strategy by which the research data generated by the project will be made open for maximizing their re-use.
This deliverable will contain a detailed documentation and description of the biomechanical models developed and the associated computer files.
OACTIVE biomechanical simulation and analysis enginesThis deliverable will contain a detailed documentation and description of the biomechanical simulations and outcomes and the associated computer files
Pubblicazioni
Autori:
C.Kokkotis; S.Moustakidis; E.Papageorgiou; G.Giakas; E.Tsaopoulos
Pubblicato in:
Osteoarthritis and Cartilage Open, 2020, ISSN 2665-9131
Editore:
Elsevier
DOI:
10.1016/j.ocarto.2020.100069
Autori:
Tomoya Iseki, Benjamin B. Rothrauff, Shinsuke Kihara, Hiroshi Sasaki, Shinichi Yoshiya, Freddie H. Fu, Rocky S. Tuan, Riccardo Gottardi
Pubblicato in:
The American Journal of Sports Medicine, Numero 47/9, 2019, Pagina/e 2188-2199, ISSN 0363-5465
Editore:
SAGE Publications
DOI:
10.1177/0363546519855645
Autori:
Dimitrios Tsaopoulos; Nikolaos Papandrianos; Elpiniki I. Papageorgiou; Christos Kokkotis; Serafeim Moustakidis; Eirini Christodoulou
Pubblicato in:
Quantum Machine Intelligence, Numero 1, 2019, ISSN 2524-4914
Editore:
Springer
DOI:
10.1007/s42484-019-00008-3
Autori:
Irene Chiesa, Carmelo De Maria, Anna Lapomarda, Gabriele Maria Fortunato, Francesca Montemurro, Roberto Di Gesù, Rocky S Tuan, Giovanni Vozzi, Riccardo Gottardi
Pubblicato in:
Biofabrication, Numero 12/2, 2020, Pagina/e 025013, ISSN 1758-5090
Editore:
IOP Science
DOI:
10.1088/1758-5090/ab6a1d
Autori:
Christos Kokkotis, Serafeim Moustakidis, Giannis Giakas, Dimitrios Tsaopoulos
Pubblicato in:
Applied Sciences, Numero 10/19, 2020, Pagina/e 6797, ISSN 2076-3417
Editore:
MDPI
DOI:
10.3390/app10196797
Autori:
Dimitar Stanev, Konstantinos Moustakas
Pubblicato in:
Journal of Biomechanics, Numero 85, 2019, Pagina/e 101-107, ISSN 0021-9290
Editore:
Elsevier BV
DOI:
10.1016/j.jbiomech.2019.01.017
Autori:
Dimitar Stanev, Konstantinos Moustakas
Pubblicato in:
PLOS ONE, Numero 14/1, 2019, Pagina/e e0209171, ISSN 1932-6203
Editore:
Public Library of Science
DOI:
10.1371/journal.pone.0209171
Autori:
Shinsuke Kihara; Riccardo Gottardi; Rocky S. Tuan; Freddie H. Fu; Benjamin B. Rothrauff; Shinichi Yoshiya; Tomoya Iseki
Pubblicato in:
Orthopaedic Journal of Sports Medicine, Numero 1, 2019, ISSN 2325-9671
Editore:
SAGE journals
DOI:
10.5281/zenodo.3696673
Autori:
Christos Kokkotis; Serafeim Moustakidis; Elpiniki Papageorgiou; Giannis Giakas; Dimitrios Tsaopoulos
Pubblicato in:
2020
Editore:
IEEE
DOI:
10.1109/iisa50023.2020.9284354
Autori:
Charis Ntakolia, Christos Kokkotis, Serafeim Moustakidis, Dimitris Tsaopoulos
Pubblicato in:
2020 IEEE 20th International Conference on Bioinformatics and Bioengineering (BIBE), 2020, Pagina/e 934-941, ISBN 978-1-7281-9574-2
Editore:
IEEE
DOI:
10.1109/bibe50027.2020.00158
Autori:
Antonios Alexos; Christos Kokkotis; Serafeim Moustakidis; Elpiniki Papageorgiou; Dimitrios Tsaopoulos
Pubblicato in:
2020
Editore:
IEEE
DOI:
10.1109/iisa50023.2020.9284379
Autori:
D.Stanev, K. Moustakas
Pubblicato in:
2018
Editore:
Virtual Physiological Human (VPH) conference
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