Volatolomics test for the diagnosis of bovine tuberculosis

Informations projet

bTB-Test

N° de convention de subvention: 777832

DOI

10.3030/777832

Projet clôturé le 31 Decembre 2019

Date de signature de la CE 17 Octobre 2017

Date de début 1 Janvier 2018

Date de fin 31 Decembre 2021

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 1 404 000,00

Contribution de l’UE

€ 1 395 000,00

Coordonné par

UPPSALA UNIVERSITET
Sweden

Periodic Reporting for period 1 - bTB-Test (Volatolomics test for the diagnosis of bovine tuberculosis)

Période du rapport: 2018-01-01 au 2019-12-31

Résumé du contexte et des objectifs généraux du projet

Bovine tuberculosis is a serious global disease with significant impact on animal health, public health, and international trade. Bovine tuberculosis can be transmitted to humans by drinking unpasteurized milk from an infected cow or eating raw or undercooked meat from an infected animal. Therefore, accurate and efficient detection of bovine tuberculosis in animal populations remains of paramount importance for bovine tuberculosis control programs. The overall objective of this project is the development a new diagnosis test for bovine tuberculosis, suitable for being performed directly on the premises in an inexpensive, fast and non-invasive way, from the analysis of volatile compounds emitted by biological samples such as breath, feces and animals skin.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

It was elaborated an optimized protocol for the collection of volatile samples emitted through the breath, feces and skin of cattle. Based on this protocol, 400 animals were samples in different countries from different continents: Romania, Tunisia, Algeria and Colombia. The analytical studies of the samples led to the identification of 6 tentative volatile biomarkers of bovine tuberculosis emitted through cattle breath, 13 tentative volatile biomarkers emitted through cattle feces, and 3 tentative volatile biomarkers emitted through cattle skin.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

This is the first time that volatile biomarkers emitted through cattle feces and skin were proposed. The results of this project could lead to a new, non-invasive and faster test for the diagnosis of bovine tuberculosis in cattle, with great impact on the livestock management.

Skin volatiles sampling

Breath sampling