Volatolomics test for the diagnosis of bovine tuberculosis

Informazioni relative al progetto

bTB-Test

ID dell’accordo di sovvenzione: 777832

DOI

10.3030/777832

Progetto concluso il 31 Dicembre 2019

Data della firma CE 17 Ottobre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 1 404 000,00

Contributo UE

€ 1 395 000,00

Coordinato da

UPPSALA UNIVERSITET
Sweden

Periodic Reporting for period 1 - bTB-Test (Volatolomics test for the diagnosis of bovine tuberculosis)

Periodo di rendicontazione: 2018-01-01 al 2019-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Bovine tuberculosis is a serious global disease with significant impact on animal health, public health, and international trade. Bovine tuberculosis can be transmitted to humans by drinking unpasteurized milk from an infected cow or eating raw or undercooked meat from an infected animal. Therefore, accurate and efficient detection of bovine tuberculosis in animal populations remains of paramount importance for bovine tuberculosis control programs. The overall objective of this project is the development a new diagnosis test for bovine tuberculosis, suitable for being performed directly on the premises in an inexpensive, fast and non-invasive way, from the analysis of volatile compounds emitted by biological samples such as breath, feces and animals skin.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

It was elaborated an optimized protocol for the collection of volatile samples emitted through the breath, feces and skin of cattle. Based on this protocol, 400 animals were samples in different countries from different continents: Romania, Tunisia, Algeria and Colombia. The analytical studies of the samples led to the identification of 6 tentative volatile biomarkers of bovine tuberculosis emitted through cattle breath, 13 tentative volatile biomarkers emitted through cattle feces, and 3 tentative volatile biomarkers emitted through cattle skin.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

This is the first time that volatile biomarkers emitted through cattle feces and skin were proposed. The results of this project could lead to a new, non-invasive and faster test for the diagnosis of bovine tuberculosis in cattle, with great impact on the livestock management.

Skin volatiles sampling

Breath sampling