Volatolomics test for the diagnosis of bovine tuberculosis

Projektinformationen

bTB-Test

ID Finanzhilfevereinbarung: 777832

DOI

10.3030/777832

Das Projekt endete am 31 Dezember 2019

EK-Unterschriftsdatum 17 Oktober 2017

Startdatum 1 Januar 2018

Enddatum 31 Dezember 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 1 404 000,00

EU-Beitrag

€ 1 395 000,00

Koordiniert durch

UPPSALA UNIVERSITET
Sweden

Periodic Reporting for period 1 - bTB-Test (Volatolomics test for the diagnosis of bovine tuberculosis)

Berichtszeitraum: 2018-01-01 bis 2019-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Bovine tuberculosis is a serious global disease with significant impact on animal health, public health, and international trade. Bovine tuberculosis can be transmitted to humans by drinking unpasteurized milk from an infected cow or eating raw or undercooked meat from an infected animal. Therefore, accurate and efficient detection of bovine tuberculosis in animal populations remains of paramount importance for bovine tuberculosis control programs. The overall objective of this project is the development a new diagnosis test for bovine tuberculosis, suitable for being performed directly on the premises in an inexpensive, fast and non-invasive way, from the analysis of volatile compounds emitted by biological samples such as breath, feces and animals skin.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

It was elaborated an optimized protocol for the collection of volatile samples emitted through the breath, feces and skin of cattle. Based on this protocol, 400 animals were samples in different countries from different continents: Romania, Tunisia, Algeria and Colombia. The analytical studies of the samples led to the identification of 6 tentative volatile biomarkers of bovine tuberculosis emitted through cattle breath, 13 tentative volatile biomarkers emitted through cattle feces, and 3 tentative volatile biomarkers emitted through cattle skin.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

This is the first time that volatile biomarkers emitted through cattle feces and skin were proposed. The results of this project could lead to a new, non-invasive and faster test for the diagnosis of bovine tuberculosis in cattle, with great impact on the livestock management.

Skin volatiles sampling

Breath sampling