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MAmmary chemoresistant Tumor deAth by Directed cell ORientation

Obiettivo

Breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. Fortunately, the availability of diagnosis tools to detect mammary neoplastic tissues, as well as transcriptomic biomarkers helping for prognosis, and the diversity of treatment options for primary tumors allows a 90% 5-year survival rate. However the metastatic grade of breast cancer is still not curable.
Advances from basic research in the last decade outline the epithelial-to-mesenchymal transition (EMT) as a key program of molecular events triggering metastatic dissemination [Nieto MA, Cell, 2016]. Impairing the EMT process appears as a very seductive way to cure breast carcinoma cancer.
Based on preliminary results obtained from “SPICY” ERC Frontier Research Starting Grant, in which we successfully develop an assay dedicated to characterize the EMT state of breast carcinoma cells [Thery M, EP 2180042 A1, 2008 ; Burute M, Dev. Cell, 2016], MATADOR is an ERC proof-of-concept project which proposes a genuine innovative strategy to develop marketable cell based assays allowing the discovery of new drugs efficiently curing mammary tumors, and create a CRO-type biotechnology company exploiting the pre-existing and newly created intellectual property: including marketable assays and therapeutics defined in MATADOR.

Campo scientifico

  • /scienze mediche e della salute/medicina clinica/oncologia/cancro/cancro al seno

Invito a presentare proposte

ERC-2017-PoC
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Meccanismo di finanziamento

ERC-POC - Proof of Concept Grant

Istituzione ospitante

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Indirizzo
Rue Leblanc 25
75015 Paris 15
Francia
Tipo di attività
Research Organisations
Contributo UE
€ 149 645

Beneficiari (1)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Francia
Contributo UE
€ 149 645
Indirizzo
Rue Leblanc 25
75015 Paris 15
Tipo di attività
Research Organisations