Identification of novel inhibitors to prevent microbial production of pro-diabetic metabolites

Projektinformationen

Drug the bug

ID Finanzhilfevereinbarung: 780659

DOI 10.3030/780659

Abgeschlossenes Projekt

EK-Unterschriftsdatum 22 November 2017

Startdatum 1 Dezember 2017

Enddatum 31 Mai 2019

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 149 700,75

EU-Beitrag € 149 700,75

Koordiniert durch

GOETEBORGS UNIVERSITET
Sweden

Ziel

The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced after surgery. In associated projects we have demonstrated that imidazole propionate is associated with type 2 diabetes in humans and induce insulin resistance in primary hepatocytes and when injected into mice. Imidazole propionate is synthesized by the microbial enzyme UrdA from histidine. This POC will explore the potential of identifying inhibitors of UrdA to reduce production of imidazole propionate and thereby improve insulin sensitivity. If successful we envision a new class of diabetes medication based on the concept of drug the bug.

Wissenschaftliches Gebiet

• Medizin- und Gesundheitswissenschaften › Klinische Medizin › Chirurgie
• Medizin- und Gesundheitswissenschaften › Grundlagenmedizin › Pharmakologie und Pharmazie › Arzneimittel
• Medizin- und Gesundheitswissenschaften › Klinische Medizin › Endokrinologie › Diabetes
• Naturwissenschaften › Biowissenschaften › Biochemie › Biomoleküle › Proteine › Enzym
• Medizin- und Gesundheitswissenschaften › Gesundheitswissenschaften › Ernährung › Fettleibigkeit

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2017-PoC - ERC-Proof of Concept

Aufforderung zur Vorschlagseinreichung

ERC-2017-PoC

Finanzierungsplan

ERC-POC - Proof of Concept Grant

Koordinator

GOETEBORGS UNIVERSITET

• Netto-EU-Beitrag: € 149 700,75
• Adresse: Vasaparken ; 405 30 Goeteborg ; Schweden
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Aktivitätstyp: Higher or Secondary Education Establishments
• Weitere Finanzmittel: € 0,00

Begünstigte (1)

GOETEBORGS UNIVERSITET

Schweden

• Netto-EU-Beitrag: € 149 700,75
• Adresse: Vasaparken ; 405 30 Goeteborg
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Aktivitätstyp: Higher or Secondary Education Establishments
• Weitere Finanzmittel: € 0,00