Obiettivo The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced after surgery. In associated projects we have demonstrated that imidazole propionate is associated with type 2 diabetes in humans and induce insulin resistance in primary hepatocytes and when injected into mice. Imidazole propionate is synthesized by the microbial enzyme UrdA from histidine. This POC will explore the potential of identifying inhibitors of UrdA to reduce production of imidazole propionate and thereby improve insulin sensitivity. If successful we envision a new class of diabetes medication based on the concept of drug the bug. Campo scientifico scienze mediche e della salutemedicina clinicachirurgiascienze mediche e della salutemedicina di basefarmacologia e farmaciafarmaciscienze mediche e della salutemedicina clinicaendocrinologiadiabetescienze naturaliscienze biologichebiochimicabiomolecoleproteineenzimiscienze mediche e della salutescienze della salutenutrizioneobesità Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2017-PoC - ERC-Proof of Concept Invito a presentare proposte ERC-2017-PoC Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-POC - Proof of Concept Grant Coordinatore GOETEBORGS UNIVERSITET Contribution nette de l'UE € 149 700,75 Indirizzo Vasaparken 405 30 Goeteborg Svezia Mostra sulla mappa Regione Södra Sverige Västsverige Västra Götalands län Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto GOETEBORGS UNIVERSITET Svezia Contribution nette de l'UE € 149 700,75 Indirizzo Vasaparken 405 30 Goeteborg Mostra sulla mappa Regione Södra Sverige Västsverige Västra Götalands län Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00
