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Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

A versatile bioelectronic interface programmed for hormone sensing (opens in new window)

Author(s): Preetam Guha Ray, Debasis Maity, Jinbo Huang, Henryk Zulewski, Martin Fussenegger
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39015-1

An electrogenetic interface to program mammalian gene expression by direct current (opens in new window)

Author(s): Jinbo Huang, Shuai Xue, Peter Buchmann, Ana Palma Teixeira, Martin Fussenegger
Published in: Nature Metabolism, Issue 5, 2023, Page(s) 1395-1407, ISSN 2522-5812
Publisher: Nature Springer
DOI: 10.1038/s42255-023-00850-7

A fully human transgene switch to regulate therapeutic protein production by cooling sensation (opens in new window)

Author(s): Peng Bai, Ying Liu, Shuai Xue, Ghislaine Charpin-El Hamri, Pratik Saxena, Haifeng Ye, Mingqi Xie, Martin Fussenegger
Published in: Nature Medicine, Issue 25/8, 2019, Page(s) 1266-1273, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0501-8

Structural materials meet synthetic biology in biomedical applications (opens in new window)

Author(s): Xiaoxuan Zhang, Martin Fussenegger
Published in: Materials Today, Issue 72, 2024, Page(s) 163-182, ISSN 1369-7021
Publisher: Elsevier BV
DOI: 10.1016/j.mattod.2023.12.008

Synthetic macromolecular switches for precision control of therapeutic cell functions (opens in new window)

Author(s): Ana Palma Teixeira, Martin Fussenegger
Published in: Nature Reviews Bioengineering, Issue 2, 2024, Page(s) 1005-1022, ISSN 2731-6092
Publisher: Nature Springer
DOI: 10.1038/s44222-024-00235-9

Regulation of Transgene Expression by the Natural Sweetener Xylose (opens in new window)

Author(s): Galvan, Silvia; Madderson, Oliver; Xue, Shuai; Teixeira, Ana P.; Fussenegger, Martin
Published in: Advanced Science, 9 (34), Issue 1, 2023, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202203193

A Gene‐Switch Platform Interfacing with Reactive Oxygen Species Enables Transcription Fine‐Tuning by Soluble and Volatile Pharmacologics and Food Additives (opens in new window)

Author(s): Jinbo Huang, Shuai Xue, Ana Palma Teixeira, Martin Fussenegger
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202306333

Phosphoregulated orthogonal signal transduction in mammalian cells (opens in new window)

Author(s): Leo Scheller, Marc Schmollack, Adrian Bertschi, Maysam Mansouri, Pratik Saxena, Martin Fussenegger
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16895-1

Smartphone-Flashlight-Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type-1 Diabetes (opens in new window)

Author(s): Mansouri, Maysam; Xue, Shuai; Hussherr, Marie-Didiée; Strittmatter, Tobias; Camenisch, Gieri; Fussenegger, Martin
Published in: Small, 17 (35), Issue 17, 2021, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202202566

Engineering Receptors in the Secretory Pathway for Orthogonal Signalling Control (opens in new window)

Author(s): Mahameed Mohamed; Wang Pengli; Xue Shuai; Fussenegger Martin
Published in: Nature Communications, Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35161-0

Identification of Sclareol As a Natural Neuroprotective Caᵥ1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery (opens in new window)

Author(s): Wang, Hui; Xie, Mingqi; Rizzi, Giorgio; Li, Xin; Tan, Kelly; Fussenegger, Martin
Published in: Advanced Science, 9 (7), Issue 1, 2022, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202102855

Synthetic biology in multicellular organisms: Opportunities in nematodes (opens in new window)

Author(s): Dmytro Kukhtar, Martin Fussenegger
Published in: Biotechnology and Bioengineering, Issue 120, 2023, Page(s) 2056-2071, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28497

Synthetic Gene Circuits for Regulation of Next‐Generation Cell‐Based Therapeutics (opens in new window)

Author(s): Ana P. Teixeira, Martin Fussenegger
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202309088

Building sophisticated sensors of extracellular cues that enable mammalian cells to work as “doctors” in the body (opens in new window)

Author(s): Ryosuke Kojima, Dominque Aubel, Martin Fussenegger
Published in: Cellular and Molecular Life Sciences, Issue 77/18, 2020, Page(s) 3567-3581, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-020-03486-y

A modular degron library for synthetic circuits in mammalian cells (opens in new window)

Author(s): Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09974-5

Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will (opens in new window)

Author(s): Ryosuke Kojima, Martin Fussenegger
Published in: ChemBioChem, Issue 20/8, 2019, Page(s) 994-1002, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800682

Programmable DARPin-based receptors for the detection of thrombotic markers (opens in new window)

Author(s): Tobias Strittmatter; Yidan Wang; Adrian Bertschi; Leo Scheller; Patrick C. Freitag; Preetam Guha Ray; Pascal Stuecheli; Jonas V. Schaefer; Thomas Reinberg; Dimitrios Tsakiris; Andreas Plückthun; Haifeng Ye; Martin Fussenegger
Published in: Nature Chemical Biology, 18, Issue 1, 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01095-3

Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells (opens in new window)

Author(s): Maysam Mansouri; Martin Fussenegger
Published in: Current Opinion in Chemical Biology, 68, Issue 5, 2022, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2022.102151

Smartphone‐Flashlight‐Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type‐1 Diabetes (opens in new window)

Author(s): Maysam Mansouri, Shuai Xue, Marie‐Didiée Hussherr, Tobias Strittmatter, Gieri Camenisch, Martin Fussenegger
Published in: Small, Issue 17/35, 2021, Page(s) 2101939, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202101939

Engineering precision therapies: lessons and motivations from the clinic (opens in new window)

Author(s): Mingqi Xie, Mirta Viviani, Martin Fussenegger
Published in: Synthetic Biology, Issue 6/1, 2021, ISSN 2397-7000
Publisher: Oxford Academic Press
DOI: 10.1093/synbio/ysaa024

Glucose‐Operated Widget (GLOW) for Closed‐Loop Optogenetic Glycemic Control (opens in new window)

Author(s): Debasis Maity, Preetam Guha Ray, Martin Fussenegger
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202408537

Programming mammalian cell behaviors by physical cues (opens in new window)

Author(s): Jinbo Huang, Martin Fussenegger
Published in: Trends in Biotechnology, Issue 43, 2025, Page(s) 16-42, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2024.07.014

Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice (opens in new window)

Author(s): Krzysztof Krawczyk, Shuai Xue, Peter Buchmann, Ghislaine Charpin-El-Hamri, Pratik Saxena, Marie-Didiée Hussherr, Jiawei Shao, Haifeng Ye, Mingqi Xie, Martin Fussenegger
Published in: Science, Issue 368/6494, 2020, Page(s) 993-1001, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau7187

Design of programmable post-translational switch control platform for on-demand protein secretion in mammalian cells (opens in new window)

Author(s): Maysam Mansouri; Preetam Guha Ray; Nik Franko; Shuai Xue; Martin Fussenegger
Published in: Nucleic Acids Research, 51 (1), Issue 1, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac916

Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant (opens in new window)

Author(s): Haijie Zhao, Shuai Xue, Marie-Didiée Hussherr, Ana Palma Teixeira, Martin Fussenegger
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm4389

From synthetic biology to human therapy: engineered mammalian cells (opens in new window)

Author(s): Leo Scheller, Martin Fussenegger
Published in: Current Opinion in Biotechnology, 2019, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.02.023

Engineering autonomous closed-loop designer cells for disease therapy. (opens in new window)

Author(s): Mohamed Mahameed; Martin Fussenegger
Published in: iScience, 25 (3), Issue 1, 2022, ISSN 2589-0042
Publisher: Cell Press Elsevier
DOI: 10.1016/j.isci.2022.103834

Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells (opens in new window)

Author(s): Viktor Haellman, Pratik Saxena, Yanrui Jiang, Martin Fussenegger
Published in: Metabolic Engineering, Issue 65, 2021, Page(s) 99-110, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2021.03.009

Small‐Molecule Regulators for Gene Switches to Program Mammalian Cell Behaviour (opens in new window)

Author(s): Maysam Mansouri, Martin Fussenegger
Published in: ChemBioChem, Issue 25, 2025, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300717

Evolution of molecular switches for regulation of transgene expression by clinically licensed gluconate (opens in new window)

Author(s): Ana Palma Teixeira, Shuai Xue, Jinbo Huang, Martin Fussenegger
Published in: Nucleic Acids Research, Issue 51, 2023, Page(s) e85-e85, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad600

5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice (opens in new window)

Author(s): Ferdinand Sedlmayer, Anne-Kathrin Woischnig, Vincent Unterreiner, Florian Fuchs, Daniel Baeschlin, Nina Khanna, Martin Fussenegger
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab251

Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo (opens in new window)

Author(s): Nik Franko, António José da Silva Santinha, Shuai Xue, Haijie Zhao, Ghislaine Charpin-El Hamri, Randall Jeffrey Platt, Ana Palma Teixeira, Martin Fussenegger
Published in: Cell Discovery, Issue 10, 2024, ISSN 2056-5968
Publisher: Nature Springer
DOI: 10.1038/s41421-023-00632-1

Genetically Encoded Protein Thermometer Enables Precise Electrothermal Control of Transgene Expression (opens in new window)

Author(s): Bozhidar‐Adrian Stefanov, Ana P. Teixeira, Maysam Mansouri, Adrian Bertschi, Krzysztof Krawczyk, Ghislaine Charpin‐El Hamri, Shuai Xue, Martin Fussenegger
Published in: Advanced Science, Issue 8/21, 2021, Page(s) 2101813, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202101813

Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins (opens in new window)

Author(s): Mohamed Mahameed, Shuai Xue, Benjamin Danuser, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
Published in: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Publisher: Nature Springer
DOI: 10.1038/s41551-025-01350-7

Engineering electrogenetic interfaces for mammalian cell control (opens in new window)

Author(s): Maysam Mansouri, Martin Fussenegger
Published in: Cell Chemical Biology, 2025, ISSN 2451-9456
Publisher: Elsevier
DOI: 10.1016/j.chembiol.2025.01.003

The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology (opens in new window)

Author(s): Bojar, Daniel; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Published in: Small, 16 (27), Issue 1, 2020, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201903093

A versatile plasmid architecture for mammalian synthetic biology (VAMSyB) (opens in new window)

Author(s): Viktor Haellman, Tobias Strittmatter, Adrian Bertschi, Pascal Stücheli, Martin Fussenegger
Published in: Metabolic Engineering, Issue 66, 2021, Page(s) 41-50, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2021.04.003

Combinatorial protein dimerization enables precise multi-input synthetic computations (opens in new window)

Author(s): Adrian Bertschi, Pengli Wang, Silvia Galvan, Ana Palma Teixeira, Martin Fussenegger
Published in: Nature Chemical Biology, 2023, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-023-01281-x

Toward Photosynthetic Mammalian Cells through Artificial Endosymbiosis (opens in new window)

Author(s): Guipeng Hu, Jinbo Huang, Martin Fussenegger
Published in: Small, Issue 20, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202310310

CelloSelect - A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines (opens in new window)

Author(s): Ana P Teixeira, Pascal Stücheli, Simon Ausländer, David Ausländer, Pascal Schönenberger, Samuel Hürlemann, Martin Fussenegger
Published in: Metabolic Engineering, 2022, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2022.01.001

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes (opens in new window)

Author(s): Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23572-4

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering (opens in new window)

Author(s): Fei Teng, Martin Fussenegger
Published in: Advanced Science, Issue 8/1, 2021, Page(s) 2003505, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202003505

Synthetic biology-based optogenetic approaches to control therapeutic designer cells (opens in new window)

Author(s): Maysam Mansouri, Martin Fussenegger
Published in: Current Opinion in Systems Biology, Issue 28, 2021, Page(s) 100396, ISSN 2452-3100
Publisher: Elsevier BV
DOI: 10.1016/j.coisb.2021.100396

dCas9-mediated dysregulation of gene expression in human induced pluripotent stem cells during primitive streak differentiation (opens in new window)

Author(s): Viktor Haellman; Martin Pirkl; Arslan Akmammedov; Pratik Saxena; Niko Beerenwinkel; Renato Paro; Ana Palma Teixeira; Martin Fussenegger
Published in: Metabolic Engineering, 73, Issue 1, 2022, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.3929/ethz-b-000557172

Blood-Glucose-Powered Metabolic Fuel Cell for Self-Sufficient Bioelectronics (opens in new window)

Author(s): Debasis Maity, Preetam Guha Ray, Peter Buchmann, Maysam Mansouri, Martin Fussenegger
Published in: Advanced Materials, 2023, ISSN 1521-4095
Publisher: Wiley-VCH
DOI: 10.1002/adma.202300890

Controlling therapeutic protein expression via inhalation of a butter flavor molecule (opens in new window)

Author(s): Adrian Bertschi; Bozhidar-Adrian Stefanov; Shuai Xue; Ghislaine Charpin-El Hamri; Ana Palma Teixeira; Martin Fussenegger
Published in: Crossref, Issue 1, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac1256

Ultrashort‐Peptide‐Responsive Gene Switches for Regulation of Therapeutic Protein Expression in Mammalian Cells (opens in new window)

Author(s): Jinbo Huang, Shuai Xue, Yu‐Qing Xie, Ana Palma Teixeira, Martin Fussenegger
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202309411

Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration (opens in new window)

Author(s): Mahameed, Mohamed; Xue, Shuai; Stefanov, Bozhidar-Adrian; Charpin-El Hamri, Ghislaine; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Published in: Advanced Science, 9 (9), Issue 1, 2022, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202105619

Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine (opens in new window)

Author(s): Stefanov, Bozhidar-Adrian; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Published in: Frontiers in Bioengineering and Biotechnology, 10, Issue 1, 2022, ISSN 2296-4185
Publisher: Frontier Media
DOI: 10.3389/fbioe.2022.986210

Skin‐Integrated Electrogenetic Regulation of Vasculature for Accelerated Wound Healing (opens in new window)

Author(s): Preetam Guha Ray, Ragavi Rajasekaran, Bitan Pratihar, Sirshendu De, Santanu Dhara, Martin Fussenegger
Published in: Advanced Science, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202412257

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells (opens in new window)

Author(s): Mansouri, Maysam; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Published in: Protein & Cell, 13 (7), Issue 1, 2022, ISSN 1674-800X
Publisher: Springer Verlag
DOI: 10.1007/s13238-021-00876-1

The sound of silence: Transgene silencing in mammalian cell engineering (opens in new window)

Author(s): Alan Cabrera, Hailey I Edelstein, Fokion Glykofrydis, Kasey S Love, Sebastian Palacios, Josh Tycko, Meng Zhang, Sarah Lensch, Cara E Shields, Mark Livingston, Ron Weiss, Huimin Zhao, Karmella A Haynes, Leonardo Morsut, Yvonne Y Chen, Ahmad S Khalil, Wilson W Wong, James J Collins, Susan J Rosser, Karen Polizzi, Michael B Elowitz, Martin Fussenegger, Isaac B Hilton, Joshua N Leonard, Lacramioara Bi
Published in: Cell Systems, 2022, ISSN 2405-4712
Publisher: Elsevier
DOI: 10.1016/j.cels.2022.11.005

Hydratable Core–Shell Polymer Networks for Atmospheric Water Harvesting Powered by Sunlight (opens in new window)

Author(s): Debasis Maity, Ana Palma Teixeira, Martin Fussenegger
Published in: Small, Issue 19, 2023, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202301427

An Efficient Ambient-Moisture–Driven Wearable Electrical Power Generator (opens in new window)

Author(s): Debasis Maity, Martin Fussenegger
Published in: Advanced Science, 2023, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202300750

Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuli (opens in new window)

Author(s): Silvia Galvan, Ana P. Teixeira, Martin Fussenegger
Published in: Biotechnology and Bioengineering, Issue 121, 2024, Page(s) 2987-3000, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28770

Emerging mammalian gene switches for controlling implantable cell therapies (opens in new window)

Author(s): Oliver Madderson, Ana Palma Teixeira, Martin Fussenegger
Published in: Current Opinion in Chemical Biology, Issue 64, 2021, Page(s) 98-105, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2021.05.012

Construction of a Multiwell Light-Induction Platform for Traceless Control of Gene Expression in Mammalian Cells. (opens in new window)

Author(s): Maysam Mansouri; Samson Lichtenstein; Tobias Strittmatter; Peter Buchmann; Martin Fussenegger; Martin Fussenegger
Published in: Methods in Molecular Biology - Photoswitching Proteins, Issue 1, 2020
Publisher: Springer
DOI: 10.1007/978-1-0716-0755-8_13

Posttranslational Remote Control Mediated by Physical Inducers for Rapid Protein Release in Engineered Mammalian Cells (opens in new window)

Author(s): Maysam Mansouri, Martin Fussenegger
Published in: Methods in Molecular Biology, Mammalian Synthetic Systems, 2024, Page(s) 233-241
Publisher: Springer US
DOI: 10.1007/978-1-0716-3718-0_15

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