Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression | ElectroGene | Project | Results | H2020 | CORDIS

Publications

A fully human transgene switch to regulate therapeutic protein production by cooling sensation

Auteurs: Peng Bai, Ying Liu, Shuai Xue, Ghislaine Charpin-El Hamri, Pratik Saxena, Haifeng Ye, Mingqi Xie, Martin Fussenegger
Publié dans: Nature Medicine, Numéro 25/8, 2019, Page(s) 1266-1273, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-019-0501-8

Regulation of Transgene Expression by the Natural Sweetener Xylose

Auteurs: Galvan, Silvia; Madderson, Oliver; Xue, Shuai; Teixeira, Ana P.; Fussenegger, Martin
Publié dans: Advanced Science, 9 (34), Numéro 1, 2023, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202203193

Phosphoregulated orthogonal signal transduction in mammalian cells

Auteurs: Leo Scheller, Marc Schmollack, Adrian Bertschi, Maysam Mansouri, Pratik Saxena, Martin Fussenegger
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-16895-1

Smartphone-Flashlight-Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type-1 Diabetes

Auteurs: Mansouri, Maysam; Xue, Shuai; Hussherr, Marie-Didiée; Strittmatter, Tobias; Camenisch, Gieri; Fussenegger, Martin
Publié dans: Small, 17 (35), Numéro 17, 2021, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202202566

Engineering Receptors in the Secretory Pathway for Orthogonal Signalling Control

Auteurs: Mahameed Mohamed; Wang Pengli; Xue Shuai; Fussenegger Martin
Publié dans: Nature Communications, Numéro 1, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-35161-0

Identification of Sclareol As a Natural Neuroprotective Caᵥ1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery

Auteurs: Wang, Hui; Xie, Mingqi; Rizzi, Giorgio; Li, Xin; Tan, Kelly; Fussenegger, Martin
Publié dans: Advanced Science, 9 (7), Numéro 1, 2022, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202102855

Building sophisticated sensors of extracellular cues that enable mammalian cells to work as “doctors” in the body

Auteurs: Ryosuke Kojima, Dominque Aubel, Martin Fussenegger
Publié dans: Cellular and Molecular Life Sciences, Numéro 77/18, 2020, Page(s) 3567-3581, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-020-03486-y

A modular degron library for synthetic circuits in mammalian cells

Auteurs: Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-09974-5

Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will

Auteurs: Ryosuke Kojima, Martin Fussenegger
Publié dans: ChemBioChem, Numéro 20/8, 2019, Page(s) 994-1002, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800682

Programmable DARPin-based receptors for the detection of thrombotic markers

Auteurs: Tobias Strittmatter; Yidan Wang; Adrian Bertschi; Leo Scheller; Patrick C. Freitag; Preetam Guha Ray; Pascal Stuecheli; Jonas V. Schaefer; Thomas Reinberg; Dimitrios Tsakiris; Andreas Plückthun; Haifeng Ye; Martin Fussenegger
Publié dans: Nature Chemical Biology, 18, Numéro 1, 2022, ISSN 1552-4450
Éditeur: Nature Publishing Group
DOI: 10.1038/s41589-022-01095-3

Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells

Auteurs: Maysam Mansouri; Martin Fussenegger
Publié dans: Current Opinion in Chemical Biology, 68, Numéro 5, 2022, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2022.102151

Smartphone‐Flashlight‐Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type‐1 Diabetes

Auteurs: Maysam Mansouri, Shuai Xue, Marie‐Didiée Hussherr, Tobias Strittmatter, Gieri Camenisch, Martin Fussenegger
Publié dans: Small, Numéro 17/35, 2021, Page(s) 2101939, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202101939

Engineering precision therapies: lessons and motivations from the clinic

Auteurs: Mingqi Xie, Mirta Viviani, Martin Fussenegger
Publié dans: Synthetic Biology, Numéro 6/1, 2021, ISSN 2397-7000
Éditeur: Oxford Academic Press
DOI: 10.1093/synbio/ysaa024

Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice

Auteurs: Krzysztof Krawczyk, Shuai Xue, Peter Buchmann, Ghislaine Charpin-El-Hamri, Pratik Saxena, Marie-Didiée Hussherr, Jiawei Shao, Haifeng Ye, Mingqi Xie, Martin Fussenegger
Publié dans: Science, Numéro 368/6494, 2020, Page(s) 993-1001, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aau7187

Design of programmable post-translational switch control platform for on-demand protein secretion in mammalian cells

Auteurs: Maysam Mansouri; Preetam Guha Ray; Nik Franko; Shuai Xue; Martin Fussenegger
Publié dans: Nucleic Acids Research, 51 (1), Numéro 1, 2023, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkac916

Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant

Auteurs: Haijie Zhao, Shuai Xue, Marie-Didiée Hussherr, Ana Palma Teixeira, Martin Fussenegger
Publié dans: Science Advances, 2022, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm4389

From synthetic biology to human therapy: engineered mammalian cells

Auteurs: Leo Scheller, Martin Fussenegger
Publié dans: Current Opinion in Biotechnology, 2019, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2019.02.023

Engineering autonomous closed-loop designer cells for disease therapy.

Auteurs: Mohamed Mahameed; Martin Fussenegger
Publié dans: iScience, 25 (3), Numéro 1, 2022, ISSN 2589-0042
Éditeur: Cell Press Elsevier
DOI: 10.1016/j.isci.2022.103834

Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells

Auteurs: Viktor Haellman, Pratik Saxena, Yanrui Jiang, Martin Fussenegger
Publié dans: Metabolic Engineering, Numéro 65, 2021, Page(s) 99-110, ISSN 1096-7176
Éditeur: Academic Press
DOI: 10.1016/j.ymben.2021.03.009

5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice

Auteurs: Ferdinand Sedlmayer, Anne-Kathrin Woischnig, Vincent Unterreiner, Florian Fuchs, Daniel Baeschlin, Nina Khanna, Martin Fussenegger
Publié dans: Nucleic Acids Research, 2021, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab251

Genetically Encoded Protein Thermometer Enables Precise Electrothermal Control of Transgene Expression

Auteurs: Bozhidar‐Adrian Stefanov, Ana P. Teixeira, Maysam Mansouri, Adrian Bertschi, Krzysztof Krawczyk, Ghislaine Charpin‐El Hamri, Shuai Xue, Martin Fussenegger
Publié dans: Advanced Science, Numéro 8/21, 2021, Page(s) 2101813, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202101813

The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology

Auteurs: Bojar, Daniel; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Publié dans: Small, 16 (27), Numéro 1, 2020, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201903093

A versatile plasmid architecture for mammalian synthetic biology (VAMSyB)

Auteurs: Viktor Haellman, Tobias Strittmatter, Adrian Bertschi, Pascal Stücheli, Martin Fussenegger
Publié dans: Metabolic Engineering, Numéro 66, 2021, Page(s) 41-50, ISSN 1096-7176
Éditeur: Academic Press
DOI: 10.1016/j.ymben.2021.04.003

Combinatorial protein dimerization enables precise multi-input synthetic computations

Auteurs: Adrian Bertschi, Pengli Wang, Silvia Galvan, Ana Palma Teixeira, Martin Fussenegger
Publié dans: Nature Chemical Biology, 2023, ISSN 1552-4450
Éditeur: Nature Publishing Group
DOI: 10.1038/s41589-023-01281-x

CelloSelect - A synthetic cellobiose metabolic pathway for selection of stable transgenic CHO cell lines

Auteurs: Ana P Teixeira, Pascal Stücheli, Simon Ausländer, David Ausländer, Pascal Schönenberger, Samuel Hürlemann, Martin Fussenegger
Publié dans: Metabolic Engineering, 2022, ISSN 1096-7176
Éditeur: Academic Press
DOI: 10.1016/j.ymben.2022.01.001

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

Auteurs: Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23572-4

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Auteurs: Fei Teng, Martin Fussenegger
Publié dans: Advanced Science, Numéro 8/1, 2021, Page(s) 2003505, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202003505

Synthetic biology-based optogenetic approaches to control therapeutic designer cells

Auteurs: Maysam Mansouri, Martin Fussenegger
Publié dans: Current Opinion in Systems Biology, Numéro 28, 2021, Page(s) 100396, ISSN 2452-3100
Éditeur: Elsevier BV
DOI: 10.1016/j.coisb.2021.100396

dCas9-mediated dysregulation of gene expression in human induced pluripotent stem cells during primitive streak differentiation

Auteurs: Viktor Haellman; Martin Pirkl; Arslan Akmammedov; Pratik Saxena; Niko Beerenwinkel; Renato Paro; Ana Palma Teixeira; Martin Fussenegger
Publié dans: Metabolic Engineering, 73, Numéro 1, 2022, ISSN 1096-7176
Éditeur: Academic Press
DOI: 10.3929/ethz-b-000557172

Blood-Glucose-Powered Metabolic Fuel Cell for Self-Sufficient Bioelectronics

Auteurs: Debasis Maity, Preetam Guha Ray, Peter Buchmann, Maysam Mansouri, Martin Fussenegger
Publié dans: Advanced Materials, 2023, ISSN 1521-4095
Éditeur: Wiley-VCH
DOI: 10.1002/adma.202300890

Controlling therapeutic protein expression via inhalation of a butter flavor molecule

Auteurs: Adrian Bertschi; Bozhidar-Adrian Stefanov; Shuai Xue; Ghislaine Charpin-El Hamri; Ana Palma Teixeira; Martin Fussenegger
Publié dans: Crossref, Numéro 1, 2023, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkac1256

Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration

Auteurs: Mahameed, Mohamed; Xue, Shuai; Stefanov, Bozhidar-Adrian; Charpin-El Hamri, Ghislaine; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Publié dans: Advanced Science, 9 (9), Numéro 1, 2022, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202105619

Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine

Auteurs: Stefanov, Bozhidar-Adrian; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Publié dans: Frontiers in Bioengineering and Biotechnology, 10, Numéro 1, 2022, ISSN 2296-4185
Éditeur: Frontier Media
DOI: 10.3389/fbioe.2022.986210

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

Auteurs: Mansouri, Maysam; Fussenegger, Martin; id_orcid0000-0001-8545-667X
Publié dans: Protein & Cell, 13 (7), Numéro 1, 2022, ISSN 1674-800X
Éditeur: Springer Verlag
DOI: 10.1007/s13238-021-00876-1

The sound of silence: Transgene silencing in mammalian cell engineering

Auteurs: Alan Cabrera, Hailey I Edelstein, Fokion Glykofrydis, Kasey S Love, Sebastian Palacios, Josh Tycko, Meng Zhang, Sarah Lensch, Cara E Shields, Mark Livingston, Ron Weiss, Huimin Zhao, Karmella A Haynes, Leonardo Morsut, Yvonne Y Chen, Ahmad S Khalil, Wilson W Wong, James J Collins, Susan J Rosser, Karen Polizzi, Michael B Elowitz, Martin Fussenegger, Isaac B Hilton, Joshua N Leonard, Lacramioara Bi
Publié dans: Cell Systems, 2022, ISSN 2405-4712
Éditeur: Elsevier
DOI: 10.1016/j.cels.2022.11.005

An Efficient Ambient-Moisture–Driven Wearable Electrical Power Generator

Auteurs: Debasis Maity, Martin Fussenegger
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202300750

Emerging mammalian gene switches for controlling implantable cell therapies

Auteurs: Oliver Madderson, Ana Palma Teixeira, Martin Fussenegger
Publié dans: Current Opinion in Chemical Biology, Numéro 64, 2021, Page(s) 98-105, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2021.05.012

Construction of a Multiwell Light-Induction Platform for Traceless Control of Gene Expression in Mammalian Cells.

Auteurs: Maysam Mansouri; Samson Lichtenstein; Tobias Strittmatter; Peter Buchmann; Martin Fussenegger; Martin Fussenegger
Publié dans: Methods in Molecular Biology - Photoswitching Proteins, Numéro 1, 2020
Éditeur: Springer
DOI: 10.1007/978-1-0716-0755-8_13

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Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression

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