Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.

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ARHGAP45 controls naïve T‐ and B‐cell entry into lymph nodes and T‐cell progenitor thymus seeding

Autori: Le He, Marie‐Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stéphane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Pubblicato in: EMBO reports, Numero 22/4, 2021, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202052196

Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors revealsmolecular plasticity of the TCR signaling pathway

Autori: Kilian Ruminski, Javier Celis-Gutierrez, Nicolas Jarmuzynski, Emilie Maturin, Stephane Audebert, Marie Malissen, Luc Camoin, Guillaume Voisinne, Bernard Malissen and Romain Roncagalli
Pubblicato in: Frontiers in Immunology, 2023, ISSN 1664-3224
Editore: Landos Biopharma
DOI: 10.3389/fimmu.2023.1139123

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN 2 as a regulator of effector functions

Autori: Marie Locard‐Paulet, Guillaume Voisinne, Carine Froment, Marisa Goncalves Menoita, Youcef Ounoughene, Laura Girard, Claude Gregoire, Daiki Mori, Manuel Martinez, Hervé Luche, Jerôme Garin, Marie Malissen, Odile Burlet‐Schiltz, Bernard Malissen, Anne Gonzalez de Peredo, Romain Roncagalli
Pubblicato in: Molecular Systems Biology, Numero 16/7, 2020, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.20209524

Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level

Autori: Joachim A, Aussel R, Gélard L, Zhang F, Mori D, Grégoire C, Villazala Merino S, Gaya M, Liang Y, Malissen M, Malissen B.J
Pubblicato in: Journal of Experimental Medicine, 2023, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20231028

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

Autori: Yunhao Zhai, Javier Celis-Gutierrez, Guillaume Voisinne, Daiki Mori, Laura Girard, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Romain Roncagalli, Bernard Malissen
Pubblicato in: Cellular & Molecular Immunology, Numero 18/6, 2021, Pagina/e 1581-1583, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-020-00575-7

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Autori: Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen
Pubblicato in: Cell Reports, Numero 27/11, 2019, Pagina/e 3315-3330.e7, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.05.041

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Autori: Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Pubblicato in: Nature Immunology, Numero 20/11, 2019, Pagina/e 1530-1541, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0489-8

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

Autori: Daiki Mori, Claude Grégoire, Guillaume Voisinne, Javier Celis-Gutierrez, Rudy Aussel, Laura Girard, Mylène Camus, Marlène Marcellin, Jérémy Argenty, Odile Burlet-Schiltz, Frédéric Fiore, Anne Gonzalez de Peredo, Marie Malissen, Romain Roncagalli, Bernard Malissen
Pubblicato in: Journal of Experimental Medicine, Numero 218/2, 2021, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20201011

Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination

Autori: Guillaume Voisinne, Marie Locard-Paulet, Carine Froment, Emilie Maturin, Marisa Goncalves Menoita, Laura Girard, Valentin Mellado, Odile Burlet-Schiltz, Bernard Malissen, Anne Gonzalez de Peredo, Romain Roncagalli
Pubblicato in: Nature Immunology, 2022, ISSN 1529-2916
Editore: Springer Nature
DOI: 10.1038/s41590-022-01288-x

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

Autori: Christian Wohn, Valentin Le Guen, Odessa Voluzan , Frédéric Fiore , Sandrine Henri, Bernard Malissen
Pubblicato in: Science Immunology, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aba1896

Systems-level conservation of the proximal TCR signaling network of mice and humans

Autori: Philippe Nicolas, Jocelyn Ollier, Daiki Mori, Guillaume Voisinne, Javier Celis-Guttierez, Claude Gregoire, Jeanne Perroteau, Régine Vivien, Mylène Camus, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Béatrice Clémenceau, Romain Roncagalli, Henri Vié, and Bernard Malissen
Pubblicato in: Journal of Experimental Medicine, 2022, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20211295

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