Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors

Información del proyecto

NECROPTOSIS

Identificador del acuerdo de subvención: 787826

DOI 10.3030/787826

Proyecto cerrado

Fecha de la firma de la CE 22 Mayo 2018

Fecha de inicio 1 Octubre 2018

Fecha de finalización 30 Septiembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 500 000,00

Aportación de la UE € 2 500 000,00

Coordinado por

UNIVERSITAT ZU KOLN
Germany

Publicaciones

Other (1)

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Autores: Lioba Körner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Huipeng Jiao, Manolis Pasparakis
Publicado en: 2023
Editor: -
DOI: 10.21203/rs.3.rs-2511750/v1

Peer reviewed articles (7)

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Autores: Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis
Publicado en: Immunity, 2020, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2020.04.002

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Autores: Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis
Publicado en: Nature, Edición 580/7803, 2020, Página(s) 391-395, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2129-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Autores: Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15466-8

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

Autores: Robin Schwarzer, Lucie Laurien, Manolis Pasparakis
Publicado en: Current Opinion in Cell Biology, Edición 63, 2020, Página(s) 186-193, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2020.02.004

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Autores: Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Be
Publicado en: Nature, Edición 577/7788, 2020, Página(s) 103-108, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1828-5

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Autores: Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
Publicado en: Nature Cell Biology, Edición 21/6, 2019, Página(s) 731-742, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-019-0324-3

ADAR1 averts fatal type I interferon induction by ZBP1

Autores: Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04878-9