Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors

Informazioni relative al progetto

NECROPTOSIS

ID dell’accordo di sovvenzione: 787826

DOI 10.3030/787826

Progetto chiuso

Data della firma CE 22 Maggio 2018

Data di avvio 1 Ottobre 2018

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 500 000,00

Contributo UE € 2 500 000,00

Coordinato da

UNIVERSITAT ZU KOLN
Germany

Pubblicazioni

Other (1)

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Autori: Lioba Körner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Huipeng Jiao, Manolis Pasparakis
Pubblicato in: 2023
Editore: -
DOI: 10.21203/rs.3.rs-2511750/v1

Peer reviewed articles (7)

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Autori: Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis
Pubblicato in: Immunity, 2020, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2020.04.002

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Autori: Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis
Pubblicato in: Nature, Numero 580/7803, 2020, Pagina/e 391-395, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2129-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Autori: Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15466-8

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

Autori: Robin Schwarzer, Lucie Laurien, Manolis Pasparakis
Pubblicato in: Current Opinion in Cell Biology, Numero 63, 2020, Pagina/e 186-193, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2020.02.004

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Autori: Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Be
Pubblicato in: Nature, Numero 577/7788, 2020, Pagina/e 103-108, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1828-5

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Autori: Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
Pubblicato in: Nature Cell Biology, Numero 21/6, 2019, Pagina/e 731-742, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-019-0324-3

ADAR1 averts fatal type I interferon induction by ZBP1

Autori: Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04878-9