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Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors

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Publications

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Author(s): Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis
Published in: Immunity, 2020, ISSN 1074-7613
DOI: 10.1016/j.immuni.2020.04.002

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Author(s): Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis
Published in: Nature, Issue 580/7803, 2020, Page(s) 391-395, ISSN 0028-0836
DOI: 10.1038/s41586-020-2129-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Author(s): Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-15466-8

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

Author(s): Robin Schwarzer, Lucie Laurien, Manolis Pasparakis
Published in: Current Opinion in Cell Biology, Issue 63, 2020, Page(s) 186-193, ISSN 0955-0674
DOI: 10.1016/j.ceb.2020.02.004

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Author(s): Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Be
Published in: Nature, Issue 577/7788, 2020, Page(s) 103-108, ISSN 0028-0836
DOI: 10.1038/s41586-019-1828-5

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Author(s): Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
Published in: Nature Cell Biology, Issue 21/6, 2019, Page(s) 731-742, ISSN 1465-7392
DOI: 10.1038/s41556-019-0324-3