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Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis (opens in new window)

Author(s): Lioba Körner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Huipeng Jiao, Manolis Pasparakis
Published in: 2023
Publisher: -
DOI: 10.21203/rs.3.rs-2511750/v1

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells (opens in new window)

Author(s): Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis
Published in: Immunity, 2020, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.04.002

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (opens in new window)

Author(s): Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis
Published in: Nature, Issue 580/7803, 2020, Page(s) 391-395, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2129-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation (opens in new window)

Author(s): Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15466-8

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8 (opens in new window)

Author(s): Robin Schwarzer, Lucie Laurien, Manolis Pasparakis
Published in: Current Opinion in Cell Biology, Issue 63, 2020, Page(s) 186-193, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.02.004

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease (opens in new window)

Author(s): Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Be
Published in: Nature, Issue 577/7788, 2020, Page(s) 103-108, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1828-5

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain (opens in new window)

Author(s): Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
Published in: Nature Cell Biology, Issue 21/6, 2019, Page(s) 731-742, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0324-3

ADAR1 averts fatal type I interferon induction by ZBP1 (opens in new window)

Author(s): Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04878-9

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