Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors

Publications

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Auteurs: Lioba Körner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Huipeng Jiao, Manolis Pasparakis
Publié dans: 2023
Éditeur: -
DOI: 10.21203/rs.3.rs-2511750/v1

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Auteurs: Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch, Manolis Pasparakis
Publié dans: Immunity, 2020, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2020.04.002

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Auteurs: Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis
Publié dans: Nature, Numéro 580/7803, 2020, Page(s) 391-395, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-020-2129-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Auteurs: Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-15466-8

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

Auteurs: Robin Schwarzer, Lucie Laurien, Manolis Pasparakis
Publié dans: Current Opinion in Cell Biology, Numéro 63, 2020, Page(s) 186-193, ISSN 0955-0674
Éditeur: Elsevier BV
DOI: 10.1016/j.ceb.2020.02.004

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Auteurs: Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl M. Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaal, Patrycja M. Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D. Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Be
Publié dans: Nature, Numéro 577/7788, 2020, Page(s) 103-108, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-019-1828-5

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Auteurs: Apostolos Polykratis, Arne Martens, Remzi Onur Eren, Yoshitaka Shirasaki, Mai Yamagishi, Yoshifumi Yamaguchi, Sotaro Uemura, Masayuki Miura, Bernhard Holzmann, George Kollias, Marietta Armaka, Geert van Loo, Manolis Pasparakis
Publié dans: Nature Cell Biology, Numéro 21/6, 2019, Page(s) 731-742, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-019-0324-3

ADAR1 averts fatal type I interferon induction by ZBP1

Auteurs: Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-04878-9

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