Deep BIOmodeling of human CARDiogenesis

Publicaciones

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Autores: Christine Schneider, Kylie S. Foo, Maria Teresa De Angelis, Gianluca Santamaria, Franziska Reiter, Tatjana Dorn, Andrea Bähr, Yat Long Tsoi, Petra Hoppmann, Ilaria My, Anna Meier, Victoria Jurisch, Nadja Hornaschewitz, Sascha Schwarz, Kun Lu, Roland Tomasi, Stefanie Sudhop, Elvira Parrotta, Marco Gaspari, Giovanni Cuda, Nikolai Klymiuk, Andreas Dendorfer, Markus Krane, Christian Kupatt, Daniel Si
Publicado en: Nature Cell Biology, Edición 24, 2022, Página(s) 659–671, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-00899-8

Domain zipping and unzipping modulates TRPM4’s properties in human cardiac conduction disease

Autores: Wenying Xian, Hongmei Wang, Alessandra Moretti, Karl‐Ludwig Laugwitz, Veit Flockerzi, Peter Lipp
Publicado en: The FASEB Journal, Edición 34/9, 2020, Página(s) 12114-12126, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202000097rr

Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models

Autores: Hilansi Rawat, Jessica Kornherr, Dorota Zawada, Sara Bakhshiyeva, Christian Kupatt, Karl-Ludwig Laugwitz, Andrea Bähr, Tatjana Dorn, Alessandra Moretti, Monika Nowak-Imialek
Publicado en: Frontiers in Cell and Developmental Biology, Edición 11, 2023, Página(s) 1111684, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2023.1111684

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Autores: Simon Alexander Sumer, Sandra Hoffmann, Svenja Laue, Birgit Campbell, Kristin Raedecke, Viktoria Frajs, Sebastian Clauss, Stefan Kääb, Johannes W.G. Janssen, Anna Jauch, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti, Gudrun A. Rappold
Publicado en: Stem Cell Reports, Edición 15/4, 2020, Página(s) 999-1013, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.08.015

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

Autores: Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz KL, Moretti A, Goedel A
Publicado en: Nature communications, 2023, Página(s) 1722, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36764-x

Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish

Autores: Martina S. Burczyk, Martin D. Burkhalter, Teresa Casar Tena, Laurel A. Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow, Monika Kustermann, Melanie Rothe, Yinghong Cui, Farah Raad, Svenja Laue, Allessandra Moretti, Wolfram-H. Zimmermann, Jürgen Wess, Michael Kühl, Carsten Hoffmann, Douglas G. Tilley, Melanie Philipp
Publicado en: JCI Insight, Edición 4/20, 2019, ISSN 2379-3708
Editor: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.121971

Human BIN1 isoforms grow, maintain, and regenerate excitation–contraction couplons in adult rat and human stem cell-derived cardiomyocytes

Autores: Jia Guo, Qinghai Tian, Monika Barth, Wenying Xian, Sandra Ruppenthal, Hans-Joachim Schaefers, Zhifen Chen, Alessandra Moretti, Karl-Ludwig Laugwitz, Peter Lipp
Publicado en: Cardiovascular Research, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvab195

Ex vivo Culture and Contractile Force Measurements of Non-human Primate Heart Slices

Autores: Christine M Poch, Andreas Dendorfer, Karl-Ludwig Laugwitz, Alessandra Moretti
Publicado en: Bio-protocol, Edición 13, 2023, Página(s) e4750, ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4750

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling

Autores: Elvira Immacolata Parrotta, Anna Procopio, Stefania Scalise, Claudia Esposito, Giovanni Nicoletta, Gianluca Santamaria, Maria Teresa De Angelis, Tatjana Dorn, Alessandra Moretti, Karl-Ludwig Laugwitz, Francesco Montefusco, Carlo Cosentino, Giovanni Cuda
Publicado en: International Journal of Molecular Sciences, Edición 22/4, 2021, Página(s) 2004, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22042004

Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium

Autores: Kun Lu, Thomas Seidel, Xiaochun Cao-Ehlker, Tatjana Dorn, Aarif Mohamed Nazeer Batcha, Christine Maria Schneider, Marie Semmler, Tilmann Volk, Alessandra Moretti, Andreas Dendorfer, Roland Tomasi
Publicado en: Theranostics, 2021, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.54999

Generation of two human iPSC lines, HMGUi003-A and MRIi028-A, carrying pathogenic biallelic variants in the PPCS gene

Autores: Arcangela Iuso, Fangfang Zhang, Ejona Rusha, Birgit Campbell, Tatjana Dorn, Enrica Zanuttigh, Dorothea Haas, Yair Anikster, Gabriele Lederer, Anna Pertek, Polyxeni Nteli, Karl-Ludwig Laugwitz, Alessandra Moretti
Publicado en: Stem cell research, Edición 61, 2022, Página(s) 102773, ISSN 1876-7753
Editor: Elsevier
DOI: 10.1016/j.scr.2022.102773

High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus

Autores: Fangfang Zhang, Anna B. Meier, Christine M. Poch, Qinghai Tian, Stefan Engelhardt, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz, Alessandra Moretti, Tatjana Dorn
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1038867

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Autores: Revital Schick, Lucy N. Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Agnes Szantai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah
Publicado en: PLOS ONE, Edición 13/10, 2018, Página(s) e0205719, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0205719

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus

Autores: Fangfang Zhang, Anna B. Meier, Daniel Sinnecker, Stefan Engelhardt, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Publicado en: Stem Cell Research, Edición 61, 2022, Página(s) 102785, ISSN 1876-7753
Editor: Elsevier
DOI: 10.1016/j.scr.2022.102785

Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease

Autores: Meier AB, Zawada D, De Angelis MT, Martens LD, Santamaria G, Zengerle S, Nowak-Imialek M, Kornherr J, Zhang F, Tian Q, Wolf CM, Kupatt C, Sahara M, Lipp P, Theis FJ, Gagneur J, Goedel A, Laugwitz KL, Dorn T, Moretti A
Publicado en: Nature Biotechnology, 2023, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-023-01718-7

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Autores: Alexander Goedel, Dorota M. Zawada, Fangfang Zhang, Zhifen Chen, Alessandra Moretti, Daniel Sinnecker
Publicado en: Journal of Visualized Experiments, Edición 139, 2018, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/58134

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block

Autores: Wenying Xian, Xin Hui, Qinghai Tian, Hongmei Wang, Alessandra Moretti, Karl-Ludwig Laugwitz, Veit Flockerzi, Sandra Ruppenthal, Peter Lipp
Publicado en: Cell Reports, Edición 24/3, 2018, Página(s) 724-731, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.06.034

Interplay of cell–cell contacts and RhoA/ MRTF ‐A signaling regulates cardiomyocyte identity

Autores: Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G S
Publicado en: The EMBO Journal, Edición 37/12, 2018, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201798133

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis

Autores: Yanchun Guo, Tatjana Dorn, Susanne J. Kühl, Alexander Linnemann, Melanie Rothe, Astrid S. Pfister, Seppo Vainio, Karl-Ludwig Laugwitz, Alessandra Moretti, Michael Kühl
Publicado en: Developmental Biology, Edición 449/1, 2019, Página(s) 1-13, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/j.ydbio.2019.02.009

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Autores: A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Fröhlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Do
Publicado en: Nature Medicine, Edición 26/2, 2020, Página(s) 207-214, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0738-2

DGK and DZHK position paper on genome editing: basic science applications and future perspective

Autores: Ralf P. Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S. Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J. Müller, Boris V. Skryabin, Thomas Thum, Wolfgang Wurst
Publicado en: Basic Research in Cardiology, Edición 116/1, 2021, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00839-3

Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines

Autores: Fangfang Zhang, Anna B. Meier, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Publicado en: Stem Cell Research, Edición 60, 2022, Página(s) 102731, ISSN 1876-7753
Editor: Elsevier
DOI: 10.1016/j.scr.2022.102731

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

Autores: Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Mako
Publicado en: Circulation, Edición 144/17, 2021, Página(s) 1409-1428, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.121.056198

Endothelial Retargeting of AAV9 In Vivo

Autores: Tarik Bozoglu, Seungmin Lee, Tilman Ziegler, Victoria Jurisch, Sanne Maas, Andrea Baehr, Rabea Hinkel, Amelie Hoenig, Anjana Hariharan, Christina Inyeop Kim, Simon Decker, Haider Sami, Tobias Koppara, Ruppert Oellinger, Oliver J. Müller, Derk Frank, Remco Megens, Peter Nelson, Christian Weber, Angelika Schnieke, Markus Sperandio, Gianluca Santamaria, Roland Rad, Alessandra Moretti, Karl‐Ludwig
Publicado en: Advanced science, Edición 9(7), 2022, Página(s) 2103867, ISSN 2198-3844
Editor: WILEY-VCH
DOI: 10.1002/advs.202103867

Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile

Autores: Dario Bongiovanni, Gianluca Santamaria, Melissa Klug, Donato Santovito, Arianna Felicetta, Michael Hristov, Moritz von Scheidt, Maria Aslani, Javier Cibella, Christian Weber, Alessandra Moretti, Karl-Ludwig Laugwitz, Clelia Peano, Isabell Bernlochner
Publicado en: Thrombosis and Haemostasis, Edición 119/11, 2019, Página(s) 1795-1806, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1055/s-0039-1695009

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Autores: Christian Kupatt, Alina Windisch, Alessandra Moretti, Eckhard Wolf, Wolfgang Wurst, Maggie C. Walter
Publicado en: Gene Therapy, 2021, ISSN 0969-7128
Editor: Nature Publishing Group
DOI: 10.1038/s41434-021-00222-4

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

Autores: Anna B Meier, Sarala Raj Murthi, Hilansi Rawat, Christopher N Toepfer, Gianluca Santamaria, Manuel Schmid, Elisa Mastantuono, Thomas Schwarzmayr, Riccardo Berutti, Julie Cleuziou, Peter Ewert, Agnes Görlach, Karin Klingel, Karl-Ludwig Laugwitz, Christine E Seidman, Jonathan G Seidman, Alessandra Moretti, Cordula M Wolf
Publicado en: iScience, Edición 25(1), 2021, Página(s) 103596, ISSN 2589-0042
Editor: Cell-Press
DOI: 10.1016/j.isci.2021.103596

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