Deep BIOmodeling of human CARDiogenesis

Informazioni relative al progetto

BIOCARD

ID dell’accordo di sovvenzione: 788381

DOI

10.3030/788381

Progetto chiuso

Data della firma CE 7 Agosto 2018

Data di avvio 1 Settembre 2018

Data di completamento 29 Febbraio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 285 625,00

Contributo UE

€ 2 285 625,00

Coordinato da

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (27)

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Autori: Christine Schneider, Kylie S. Foo, Maria Teresa De Angelis, Gianluca Santamaria, Franziska Reiter, Tatjana Dorn, Andrea Bähr, Yat Long Tsoi, Petra Hoppmann, Ilaria My, Anna Meier, Victoria Jurisch, Nadja Hornaschewitz, Sascha Schwarz, Kun Lu, Roland Tomasi, Stefanie Sudhop, Elvira Parrotta, Marco Gaspari, Giovanni Cuda, Nikolai Klymiuk, Andreas Dendorfer, Markus Krane, Christian Kupatt, Daniel Si
Pubblicato in: Nature Cell Biology, Numero 24, 2022, Pagina/e 659–671, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-022-00899-8

Domain zipping and unzipping modulates TRPM4’s properties in human cardiac conduction disease

Autori: Wenying Xian, Hongmei Wang, Alessandra Moretti, Karl‐Ludwig Laugwitz, Veit Flockerzi, Peter Lipp
Pubblicato in: The FASEB Journal, Numero 34/9, 2020, Pagina/e 12114-12126, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202000097rr

Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models

Autori: Hilansi Rawat, Jessica Kornherr, Dorota Zawada, Sara Bakhshiyeva, Christian Kupatt, Karl-Ludwig Laugwitz, Andrea Bähr, Tatjana Dorn, Alessandra Moretti, Monika Nowak-Imialek
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 11, 2023, Pagina/e 1111684, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2023.1111684

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Autori: Simon Alexander Sumer, Sandra Hoffmann, Svenja Laue, Birgit Campbell, Kristin Raedecke, Viktoria Frajs, Sebastian Clauss, Stefan Kääb, Johannes W.G. Janssen, Anna Jauch, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti, Gudrun A. Rappold
Pubblicato in: Stem Cell Reports, Numero 15/4, 2020, Pagina/e 999-1013, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.08.015

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

Autori: Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz KL, Moretti A, Goedel A
Pubblicato in: Nature communications, 2023, Pagina/e 1722, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36764-x

Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish

Autori: Martina S. Burczyk, Martin D. Burkhalter, Teresa Casar Tena, Laurel A. Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow, Monika Kustermann, Melanie Rothe, Yinghong Cui, Farah Raad, Svenja Laue, Allessandra Moretti, Wolfram-H. Zimmermann, Jürgen Wess, Michael Kühl, Carsten Hoffmann, Douglas G. Tilley, Melanie Philipp
Pubblicato in: JCI Insight, Numero 4/20, 2019, ISSN 2379-3708
Editore: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.121971

Human BIN1 isoforms grow, maintain, and regenerate excitation–contraction couplons in adult rat and human stem cell-derived cardiomyocytes

Autori: Jia Guo, Qinghai Tian, Monika Barth, Wenying Xian, Sandra Ruppenthal, Hans-Joachim Schaefers, Zhifen Chen, Alessandra Moretti, Karl-Ludwig Laugwitz, Peter Lipp
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab195

Ex vivo Culture and Contractile Force Measurements of Non-human Primate Heart Slices

Autori: Christine M Poch, Andreas Dendorfer, Karl-Ludwig Laugwitz, Alessandra Moretti
Pubblicato in: Bio-protocol, Numero 13, 2023, Pagina/e e4750, ISSN 2331-8325
Editore: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4750

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling

Autori: Elvira Immacolata Parrotta, Anna Procopio, Stefania Scalise, Claudia Esposito, Giovanni Nicoletta, Gianluca Santamaria, Maria Teresa De Angelis, Tatjana Dorn, Alessandra Moretti, Karl-Ludwig Laugwitz, Francesco Montefusco, Carlo Cosentino, Giovanni Cuda
Pubblicato in: International Journal of Molecular Sciences, Numero 22/4, 2021, Pagina/e 2004, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22042004

Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium

Autori: Kun Lu, Thomas Seidel, Xiaochun Cao-Ehlker, Tatjana Dorn, Aarif Mohamed Nazeer Batcha, Christine Maria Schneider, Marie Semmler, Tilmann Volk, Alessandra Moretti, Andreas Dendorfer, Roland Tomasi
Pubblicato in: Theranostics, 2021, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.54999

Generation of two human iPSC lines, HMGUi003-A and MRIi028-A, carrying pathogenic biallelic variants in the PPCS gene

Autori: Arcangela Iuso, Fangfang Zhang, Ejona Rusha, Birgit Campbell, Tatjana Dorn, Enrica Zanuttigh, Dorothea Haas, Yair Anikster, Gabriele Lederer, Anna Pertek, Polyxeni Nteli, Karl-Ludwig Laugwitz, Alessandra Moretti
Pubblicato in: Stem cell research, Numero 61, 2022, Pagina/e 102773, ISSN 1876-7753
Editore: Elsevier
DOI: 10.1016/j.scr.2022.102773

High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus

Autori: Fangfang Zhang, Anna B. Meier, Christine M. Poch, Qinghai Tian, Stefan Engelhardt, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz, Alessandra Moretti, Tatjana Dorn
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1038867

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Autori: Revital Schick, Lucy N. Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Agnes Szantai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah
Pubblicato in: PLOS ONE, Numero 13/10, 2018, Pagina/e e0205719, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0205719

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus

Autori: Fangfang Zhang, Anna B. Meier, Daniel Sinnecker, Stefan Engelhardt, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Pubblicato in: Stem Cell Research, Numero 61, 2022, Pagina/e 102785, ISSN 1876-7753
Editore: Elsevier
DOI: 10.1016/j.scr.2022.102785

Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease

Autori: Meier AB, Zawada D, De Angelis MT, Martens LD, Santamaria G, Zengerle S, Nowak-Imialek M, Kornherr J, Zhang F, Tian Q, Wolf CM, Kupatt C, Sahara M, Lipp P, Theis FJ, Gagneur J, Goedel A, Laugwitz KL, Dorn T, Moretti A
Pubblicato in: Nature Biotechnology, 2023, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-01718-7

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Autori: Alexander Goedel, Dorota M. Zawada, Fangfang Zhang, Zhifen Chen, Alessandra Moretti, Daniel Sinnecker
Pubblicato in: Journal of Visualized Experiments, Numero 139, 2018, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/58134

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block

Autori: Wenying Xian, Xin Hui, Qinghai Tian, Hongmei Wang, Alessandra Moretti, Karl-Ludwig Laugwitz, Veit Flockerzi, Sandra Ruppenthal, Peter Lipp
Pubblicato in: Cell Reports, Numero 24/3, 2018, Pagina/e 724-731, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.06.034

Interplay of cell–cell contacts and RhoA/ MRTF ‐A signaling regulates cardiomyocyte identity

Autori: Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G S
Pubblicato in: The EMBO Journal, Numero 37/12, 2018, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201798133

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis

Autori: Yanchun Guo, Tatjana Dorn, Susanne J. Kühl, Alexander Linnemann, Melanie Rothe, Astrid S. Pfister, Seppo Vainio, Karl-Ludwig Laugwitz, Alessandra Moretti, Michael Kühl
Pubblicato in: Developmental Biology, Numero 449/1, 2019, Pagina/e 1-13, ISSN 0012-1606
Editore: Academic Press
DOI: 10.1016/j.ydbio.2019.02.009

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Autori: A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Fröhlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Do
Pubblicato in: Nature Medicine, Numero 26/2, 2020, Pagina/e 207-214, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0738-2

DGK and DZHK position paper on genome editing: basic science applications and future perspective

Autori: Ralf P. Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S. Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J. Müller, Boris V. Skryabin, Thomas Thum, Wolfgang Wurst
Pubblicato in: Basic Research in Cardiology, Numero 116/1, 2021, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00839-3

Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines

Autori: Fangfang Zhang, Anna B. Meier, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Pubblicato in: Stem Cell Research, Numero 60, 2022, Pagina/e 102731, ISSN 1876-7753
Editore: Elsevier
DOI: 10.1016/j.scr.2022.102731

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

Autori: Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Mako
Pubblicato in: Circulation, Numero 144/17, 2021, Pagina/e 1409-1428, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.121.056198

Endothelial Retargeting of AAV9 In Vivo

Autori: Tarik Bozoglu, Seungmin Lee, Tilman Ziegler, Victoria Jurisch, Sanne Maas, Andrea Baehr, Rabea Hinkel, Amelie Hoenig, Anjana Hariharan, Christina Inyeop Kim, Simon Decker, Haider Sami, Tobias Koppara, Ruppert Oellinger, Oliver J. Müller, Derk Frank, Remco Megens, Peter Nelson, Christian Weber, Angelika Schnieke, Markus Sperandio, Gianluca Santamaria, Roland Rad, Alessandra Moretti, Karl‐Ludwig
Pubblicato in: Advanced science, Numero 9(7), 2022, Pagina/e 2103867, ISSN 2198-3844
Editore: WILEY-VCH
DOI: 10.1002/advs.202103867

Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile

Autori: Dario Bongiovanni, Gianluca Santamaria, Melissa Klug, Donato Santovito, Arianna Felicetta, Michael Hristov, Moritz von Scheidt, Maria Aslani, Javier Cibella, Christian Weber, Alessandra Moretti, Karl-Ludwig Laugwitz, Clelia Peano, Isabell Bernlochner
Pubblicato in: Thrombosis and Haemostasis, Numero 119/11, 2019, Pagina/e 1795-1806, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/s-0039-1695009

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Autori: Christian Kupatt, Alina Windisch, Alessandra Moretti, Eckhard Wolf, Wolfgang Wurst, Maggie C. Walter
Pubblicato in: Gene Therapy, 2021, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00222-4

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

Autori: Anna B Meier, Sarala Raj Murthi, Hilansi Rawat, Christopher N Toepfer, Gianluca Santamaria, Manuel Schmid, Elisa Mastantuono, Thomas Schwarzmayr, Riccardo Berutti, Julie Cleuziou, Peter Ewert, Agnes Görlach, Karin Klingel, Karl-Ludwig Laugwitz, Christine E Seidman, Jonathan G Seidman, Alessandra Moretti, Cordula M Wolf
Pubblicato in: iScience, Numero 25(1), 2021, Pagina/e 103596, ISSN 2589-0042
Editore: Cell-Press
DOI: 10.1016/j.isci.2021.103596

Diritti di proprietà intellettuale

Patent (1)

HEART TISSUE MODELS, METHOD OF PRODUCING HEART TISSUE MODELS AND USES OF HEART TISSUE MODELS

Numero candidatura/pubblicazione: 22 164561
Data: 2022-03-25
Candidato/i: KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)