Deep BIOmodeling of human CARDiogenesis

Publications

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Auteurs: Christine Schneider, Kylie S. Foo, Maria Teresa De Angelis, Gianluca Santamaria, Franziska Reiter, Tatjana Dorn, Andrea Bähr, Yat Long Tsoi, Petra Hoppmann, Ilaria My, Anna Meier, Victoria Jurisch, Nadja Hornaschewitz, Sascha Schwarz, Kun Lu, Roland Tomasi, Stefanie Sudhop, Elvira Parrotta, Marco Gaspari, Giovanni Cuda, Nikolai Klymiuk, Andreas Dendorfer, Markus Krane, Christian Kupatt, Daniel Si
Publié dans: Nature Cell Biology, Numéro 24, 2022, Page(s) 659–671, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-022-00899-8

Domain zipping and unzipping modulates TRPM4’s properties in human cardiac conduction disease

Auteurs: Wenying Xian, Hongmei Wang, Alessandra Moretti, Karl‐Ludwig Laugwitz, Veit Flockerzi, Peter Lipp
Publié dans: The FASEB Journal, Numéro 34/9, 2020, Page(s) 12114-12126, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202000097rr

Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models

Auteurs: Hilansi Rawat, Jessica Kornherr, Dorota Zawada, Sara Bakhshiyeva, Christian Kupatt, Karl-Ludwig Laugwitz, Andrea Bähr, Tatjana Dorn, Alessandra Moretti, Monika Nowak-Imialek
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 11, 2023, Page(s) 1111684, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2023.1111684

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Auteurs: Simon Alexander Sumer, Sandra Hoffmann, Svenja Laue, Birgit Campbell, Kristin Raedecke, Viktoria Frajs, Sebastian Clauss, Stefan Kääb, Johannes W.G. Janssen, Anna Jauch, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti, Gudrun A. Rappold
Publié dans: Stem Cell Reports, Numéro 15/4, 2020, Page(s) 999-1013, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2020.08.015

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

Auteurs: Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz KL, Moretti A, Goedel A
Publié dans: Nature communications, 2023, Page(s) 1722, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-36764-x

Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish

Auteurs: Martina S. Burczyk, Martin D. Burkhalter, Teresa Casar Tena, Laurel A. Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow, Monika Kustermann, Melanie Rothe, Yinghong Cui, Farah Raad, Svenja Laue, Allessandra Moretti, Wolfram-H. Zimmermann, Jürgen Wess, Michael Kühl, Carsten Hoffmann, Douglas G. Tilley, Melanie Philipp
Publié dans: JCI Insight, Numéro 4/20, 2019, ISSN 2379-3708
Éditeur: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.121971

Human BIN1 isoforms grow, maintain, and regenerate excitation–contraction couplons in adult rat and human stem cell-derived cardiomyocytes

Auteurs: Jia Guo, Qinghai Tian, Monika Barth, Wenying Xian, Sandra Ruppenthal, Hans-Joachim Schaefers, Zhifen Chen, Alessandra Moretti, Karl-Ludwig Laugwitz, Peter Lipp
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab195

Ex vivo Culture and Contractile Force Measurements of Non-human Primate Heart Slices

Auteurs: Christine M Poch, Andreas Dendorfer, Karl-Ludwig Laugwitz, Alessandra Moretti
Publié dans: Bio-protocol, Numéro 13, 2023, Page(s) e4750, ISSN 2331-8325
Éditeur: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4750

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling

Auteurs: Elvira Immacolata Parrotta, Anna Procopio, Stefania Scalise, Claudia Esposito, Giovanni Nicoletta, Gianluca Santamaria, Maria Teresa De Angelis, Tatjana Dorn, Alessandra Moretti, Karl-Ludwig Laugwitz, Francesco Montefusco, Carlo Cosentino, Giovanni Cuda
Publié dans: International Journal of Molecular Sciences, Numéro 22/4, 2021, Page(s) 2004, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22042004

Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium

Auteurs: Kun Lu, Thomas Seidel, Xiaochun Cao-Ehlker, Tatjana Dorn, Aarif Mohamed Nazeer Batcha, Christine Maria Schneider, Marie Semmler, Tilmann Volk, Alessandra Moretti, Andreas Dendorfer, Roland Tomasi
Publié dans: Theranostics, 2021, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.54999

Generation of two human iPSC lines, HMGUi003-A and MRIi028-A, carrying pathogenic biallelic variants in the PPCS gene

Auteurs: Arcangela Iuso, Fangfang Zhang, Ejona Rusha, Birgit Campbell, Tatjana Dorn, Enrica Zanuttigh, Dorothea Haas, Yair Anikster, Gabriele Lederer, Anna Pertek, Polyxeni Nteli, Karl-Ludwig Laugwitz, Alessandra Moretti
Publié dans: Stem cell research, Numéro 61, 2022, Page(s) 102773, ISSN 1876-7753
Éditeur: Elsevier
DOI: 10.1016/j.scr.2022.102773

High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus

Auteurs: Fangfang Zhang, Anna B. Meier, Christine M. Poch, Qinghai Tian, Stefan Engelhardt, Daniel Sinnecker, Peter Lipp, Karl-Ludwig Laugwitz, Alessandra Moretti, Tatjana Dorn
Publié dans: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1038867

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Auteurs: Revital Schick, Lucy N. Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Agnes Szantai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah
Publié dans: PLOS ONE, Numéro 13/10, 2018, Page(s) e0205719, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0205719

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus

Auteurs: Fangfang Zhang, Anna B. Meier, Daniel Sinnecker, Stefan Engelhardt, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Publié dans: Stem Cell Research, Numéro 61, 2022, Page(s) 102785, ISSN 1876-7753
Éditeur: Elsevier
DOI: 10.1016/j.scr.2022.102785

Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease

Auteurs: Meier AB, Zawada D, De Angelis MT, Martens LD, Santamaria G, Zengerle S, Nowak-Imialek M, Kornherr J, Zhang F, Tian Q, Wolf CM, Kupatt C, Sahara M, Lipp P, Theis FJ, Gagneur J, Goedel A, Laugwitz KL, Dorn T, Moretti A
Publié dans: Nature Biotechnology, 2023, ISSN 1087-0156
Éditeur: Nature Publishing Group
DOI: 10.1038/s41587-023-01718-7

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Auteurs: Alexander Goedel, Dorota M. Zawada, Fangfang Zhang, Zhifen Chen, Alessandra Moretti, Daniel Sinnecker
Publié dans: Journal of Visualized Experiments, Numéro 139, 2018, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/58134

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block

Auteurs: Wenying Xian, Xin Hui, Qinghai Tian, Hongmei Wang, Alessandra Moretti, Karl-Ludwig Laugwitz, Veit Flockerzi, Sandra Ruppenthal, Peter Lipp
Publié dans: Cell Reports, Numéro 24/3, 2018, Page(s) 724-731, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.06.034

Interplay of cell–cell contacts and RhoA/ MRTF ‐A signaling regulates cardiomyocyte identity

Auteurs: Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G S
Publié dans: The EMBO Journal, Numéro 37/12, 2018, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.201798133

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis

Auteurs: Yanchun Guo, Tatjana Dorn, Susanne J. Kühl, Alexander Linnemann, Melanie Rothe, Astrid S. Pfister, Seppo Vainio, Karl-Ludwig Laugwitz, Alessandra Moretti, Michael Kühl
Publié dans: Developmental Biology, Numéro 449/1, 2019, Page(s) 1-13, ISSN 0012-1606
Éditeur: Academic Press
DOI: 10.1016/j.ydbio.2019.02.009

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Auteurs: A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Fröhlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Do
Publié dans: Nature Medicine, Numéro 26/2, 2020, Page(s) 207-214, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-019-0738-2

DGK and DZHK position paper on genome editing: basic science applications and future perspective

Auteurs: Ralf P. Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S. Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J. Müller, Boris V. Skryabin, Thomas Thum, Wolfgang Wurst
Publié dans: Basic Research in Cardiology, Numéro 116/1, 2021, ISSN 0300-8428
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00839-3

Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines

Auteurs: Fangfang Zhang, Anna B. Meier, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Publié dans: Stem Cell Research, Numéro 60, 2022, Page(s) 102731, ISSN 1876-7753
Éditeur: Elsevier
DOI: 10.1016/j.scr.2022.102731

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

Auteurs: Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Mako
Publié dans: Circulation, Numéro 144/17, 2021, Page(s) 1409-1428, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.121.056198

Endothelial Retargeting of AAV9 In Vivo

Auteurs: Tarik Bozoglu, Seungmin Lee, Tilman Ziegler, Victoria Jurisch, Sanne Maas, Andrea Baehr, Rabea Hinkel, Amelie Hoenig, Anjana Hariharan, Christina Inyeop Kim, Simon Decker, Haider Sami, Tobias Koppara, Ruppert Oellinger, Oliver J. Müller, Derk Frank, Remco Megens, Peter Nelson, Christian Weber, Angelika Schnieke, Markus Sperandio, Gianluca Santamaria, Roland Rad, Alessandra Moretti, Karl‐Ludwig
Publié dans: Advanced science, Numéro 9(7), 2022, Page(s) 2103867, ISSN 2198-3844
Éditeur: WILEY-VCH
DOI: 10.1002/advs.202103867

Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile

Auteurs: Dario Bongiovanni, Gianluca Santamaria, Melissa Klug, Donato Santovito, Arianna Felicetta, Michael Hristov, Moritz von Scheidt, Maria Aslani, Javier Cibella, Christian Weber, Alessandra Moretti, Karl-Ludwig Laugwitz, Clelia Peano, Isabell Bernlochner
Publié dans: Thrombosis and Haemostasis, Numéro 119/11, 2019, Page(s) 1795-1806, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/s-0039-1695009

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Auteurs: Christian Kupatt, Alina Windisch, Alessandra Moretti, Eckhard Wolf, Wolfgang Wurst, Maggie C. Walter
Publié dans: Gene Therapy, 2021, ISSN 0969-7128
Éditeur: Nature Publishing Group
DOI: 10.1038/s41434-021-00222-4

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

Auteurs: Anna B Meier, Sarala Raj Murthi, Hilansi Rawat, Christopher N Toepfer, Gianluca Santamaria, Manuel Schmid, Elisa Mastantuono, Thomas Schwarzmayr, Riccardo Berutti, Julie Cleuziou, Peter Ewert, Agnes Görlach, Karin Klingel, Karl-Ludwig Laugwitz, Christine E Seidman, Jonathan G Seidman, Alessandra Moretti, Cordula M Wolf
Publié dans: iScience, Numéro 25(1), 2021, Page(s) 103596, ISSN 2589-0042
Éditeur: Cell-Press
DOI: 10.1016/j.isci.2021.103596

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