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Role of protein crystallization in type 2 immunity and asthma

Publications

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Author(s): Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N. Lambrecht
Published in: Journal of Allergy and Clinical Immunology, Issue 142/4, 2018, Page(s) 1185-1193.e4, ISSN 0091-6749
DOI: 10.1016/j.jaci.2018.06.002

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Author(s): Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Be
Published in: European Respiratory Journal, Issue 53/6, 2019, Page(s) 1900453, ISSN 0903-1936
DOI: 10.1183/13993003.00453-2019

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Author(s): Cedric Bosteels, Katrijn Neyt, Manon Vanheerswynghels, Mary J. van Helden, Dorine Sichien, Nincy Debeuf, Sofie De Prijck, Victor Bosteels, Niels Vandamme, Liesbet Martens, Yvan Saeys, Els Louagie, Manon Lesage, David L. Williams, Shiau-Choot Tang, Johannes U. Mayer, Franca Ronchese, Charlotte L. Scott, Hamida Hammad, Martin Guilliams, Bart N. Lambrecht
Published in: Immunity, Issue 52/6, 2020, Page(s) 1039-1056.e9, ISSN 1074-7613
DOI: 10.1016/j.immuni.2020.04.005

Local immune response to food antigens drives meal-induced abdominal pain

Author(s): Javier Aguilera-Lizarraga, Morgane V. Florens, Maria Francesca Viola, Piyush Jain, Lisse Decraecker, Iris Appeltans, Maria Cuende-Estevez, Naomi Fabre, Kim Van Beek, Eluisa Perna, Dafne Balemans, Nathalie Stakenborg, Stavroula Theofanous, Goele Bosmans, Stéphanie U. Mondelaers, Gianluca Matteoli, Sales Ibiza Martínez, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Karel Talavera, Yeranddy A. Alpiz
Published in: Nature, Issue 590/7844, 2021, Page(s) 151-156, ISSN 0028-0836
DOI: 10.1038/s41586-020-03118-2

CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01

Author(s): Cedric Bosteels, Kaat Fierens, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Caroline De Wolf, Aurélie Chalon, Catherine Collignon, Hamida Hammad, Arnaud M. Didierlaurent, Bart N. Lambrecht
Published in: Frontiers in Immunology, Issue 11, 2021, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.606805

Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity

Author(s): Martijn J. Schuijs, Hamida Hammad, Bart N. Lambrecht
Published in: Trends in Immunology, Issue 40/1, 2019, Page(s) 22-34, ISSN 1471-4906
DOI: 10.1016/j.it.2018.11.001

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Author(s): Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht
Published in: Journal of Allergy and Clinical Immunology, Issue 144/6, 2019, Page(s) 1648-1659.e9, ISSN 0091-6749
DOI: 10.1016/j.jaci.2019.06.041

Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March

Author(s): Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Karolien De Bosscher
Published in: Journal of Investigative Dermatology, Issue 138/6, 2018, Page(s) 1360-1370, ISSN 0022-202X
DOI: 10.1016/j.jid.2017.12.023

IL-33trap is a novel IL-33–neutralizing biologic that inhibits allergic airway inflammation

Author(s): Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J. Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N. Lambrecht, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert
Published in: Journal of Allergy and Clinical Immunology, Issue 144/1, 2019, Page(s) 204-215, ISSN 0091-6749
DOI: 10.1016/j.jaci.2019.02.028

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Author(s): Hamida Hammad, Bart N. Lambrecht
Published in: Nature Immunology, Issue 21/11, 2020, Page(s) 1313-1314, ISSN 1529-2908
DOI: 10.1038/s41590-020-0797-z

Isolated Schistosoma mansoni eggs prevent allergic airway inflammation

Author(s): Katja Obieglo, Martijn J. Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N. Lambrecht, Christian Taube, Hermelijn H. Smits
Published in: Parasite Immunology, Issue 40/10, 2018, Page(s) e12579, ISSN 0141-9838
DOI: 10.1111/pim.12579

How a farming environment protects from atopy

Author(s): Julie Deckers, Bart N Lambrecht, Hamida Hammad
Published in: Current Opinion in Immunology, Issue 60, 2019, Page(s) 163-169, ISSN 0952-7915
DOI: 10.1016/j.coi.2019.08.001

The hygiene hypothesis: immunological mechanisms of airway tolerance

Author(s): Eline Haspeslagh, Ines Heyndrickx, Hamida Hammad, Bart N Lambrecht
Published in: Current Opinion in Immunology, Issue 54, 2018, Page(s) 102-108, ISSN 0952-7915
DOI: 10.1016/j.coi.2018.06.007

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects

Author(s): Marie Godar, Christophe Blanchetot, Hans de Haard, Bart N. Lambrecht, Guy Brusselle
Published in: mAbs, Issue 10/1, 2018, Page(s) 34-45, ISSN 1942-0870
DOI: 10.1080/19420862.2017.1392425

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Author(s): Eline Haspeslagh, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Alain Jacquet, Bart N. Lambrecht, Hamida Hammad
Published in: Journal of Allergy and Clinical Immunology, Issue 143/6, 2019, Page(s) 2307-2311.e5, ISSN 0091-6749
DOI: 10.1016/j.jaci.2019.02.007

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Author(s): Elien Gevaert, Tim Delemarre, Joyceline De Volder, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Emma Persson, Ines Heyndrickx, Kenneth Verstraete, Helena Aegerter, Hans Nauwynck, Savvas N. Savvides, Bart N. Lambrecht, Claus Bachert
Published in: Journal of Allergy and Clinical Immunology, Issue 145/1, 2020, Page(s) 427-430.e4, ISSN 0091-6749
DOI: 10.1016/j.jaci.2019.08.027

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Author(s): Emma K. Persson, Kenneth Verstraete, Ines Heyndrickx, Elien Gevaert, Helena Aegerter, Jean-Michel Percier, Kim Deswarte, Koen H. G. Verschueren, Ann Dansercoer, Delphine Gras, Pascal Chanez, Claus Bachert, Amanda Gonçalves, Hanne Van Gorp, Hans De Haard, Christophe Blanchetot, Michael Saunders, Hamida Hammad, Savvas N. Savvides, Bart N. Lambrecht
Published in: Science, Issue 364/6442, 2019, Page(s) eaaw4295, ISSN 0036-8075
DOI: 10.1126/science.aaw4295

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Author(s): Heleen Vroman, Denise Uden, Ingrid M. Bergen, Jennifer A. C. Hulst, Melanie Lukkes, Geert Loo, Björn E. Clausen, Louis Boon, Bart N. Lambrecht, Hamida Hammad, Rudi W. Hendriks, Mirjam Kool
Published in: Allergy, Issue 75/10, 2020, Page(s) 2587-2598, ISSN 0105-4538
DOI: 10.1111/all.14334

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology

Author(s): S. Post, I. H. Heijink, L. Hesse, H. K. Koo, F. Shaheen, M. Fouadi, V. N. S. Kuchibhotla, B. N. Lambrecht, A. J. M. Van Oosterhout, T. L. Hackett, M. C. Nawijn
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-31500-8

Eicosanoid Control Over Antigen Presenting Cells in Asthma

Author(s): Nincy Debeuf, Bart N. Lambrecht
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.02006

An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Author(s): Sheena C. Kerr, Jeanmarie R. Gonzalez, Julia Schanin, Michael C. Peters, Bart N. Lambrecht, Emily C. Brock, Annabelle Charbit, K. M. Ansel, Bradford A. Youngblood, John V. Fahy
Published in: Clinical & Experimental Allergy, Issue 50/8, 2020, Page(s) 904-914, ISSN 0954-7894
DOI: 10.1111/cea.13681

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

Author(s): Themis Alissafi, Evangelia Kourepini, Davina C. M. Simoes, Nikolaos Paschalidis, Maria Aggelakopoulou, Tim Sparwasser, Louis Boon, Hamida Hammad, Bart N. Lambrecht, Vily Panoutsakopoulou
Published in: The Journal of Immunology, Issue 200/4, 2018, Page(s) 1270-1282, ISSN 0022-1767
DOI: 10.4049/jimmunol.1701345

Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease

Author(s): Thomas Naessens, Yannick Morias, Eva Hamrud, Ulf Gehrmann, Ramachandramouli Budida, Johan Mattsson, Tina Baker, Gabriel Skogberg, Elisabeth Israelsson, Kristofer Thörn, Martijn J. Schuijs, Bastian Angermann, Faye Melville, Karl J. Staples, Danen M. Cunoosamy, Bart N. Lambrecht
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 202/4, 2020, Page(s) 535-548, ISSN 1073-449X
DOI: 10.1164/rccm.201906-1123oc

TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells

Author(s): Matthias Vanderkerken, Bastiaan Maes, Lana Vandersarren, Wendy Toussaint, Kim Deswarte, Manon Vanheerswynghels, Philippe Pouliot, Liesbet Martens, Sofie Van Gassen, Connie M. Arthur, Margaret E. Kirkling, Boris Reizis, Daniel Conrad, Sean Stowell, Hamida Hammad, Bart N. Lambrecht
Published in: Proceedings of the National Academy of Sciences, Issue 117/49, 2020, Page(s) 31331-31342, ISSN 0027-8424
DOI: 10.1073/pnas.2009847117